753(top 1%)
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41.8K(top 0.1%)
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96(top 0.1%)
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Top Articles

#TitleJournalYearCitations
1A comprehensive classification system for lipidsJournal of Lipid Research20051,348
2The Nature of the Arrestin·Receptor Complex Determines the Ultimate Fate of the Internalized ReceptorJournal of Biological Chemistry20031,245
3Molecular mechanism for an inherited cardiac arrhythmiaNature1995919
4The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor familyCell1989553
5Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and PharmacogeneticsGastroenterology2006542
6Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric ModulatorScience2014476
7A transient placental source of serotonin for the fetal forebrainNature2011475
8The structural basis of arrestin-mediated regulation of G-protein-coupled receptorsNature2006404
9Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's diseaseProgress in Neurobiology2015379
10Requirement of Type III TGF- Receptor for Endocardial Cell Transformation in the HeartScience1999361
11Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M1Muscarinic Acetylcholine ReceptorJournal of Neuroscience2001344
12Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α-synucleinJournal of Neurochemistry2004328
13The molecular acrobatics of arrestin activationTrends in Pharmacological Sciences2004327
14Metabotropic glutamate receptors in the basal ganglia motor circuitNature Reviews Neuroscience2005297
15Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts LearningJournal of Neuroscience2010281
16The multifaceted role of fibrinogen in tissue injury and inflammationBlood2019279
17Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient MiceCirculation2002278
18A Dialogue between the Immune System and Brain, Spoken in the Language of SerotoninACS Chemical Neuroscience2013260
1915-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal CancerJournal of Biological Chemistry2005242
20Macrophages, inflammation, and atherosclerosisInternational Journal of Obesity2003229
21Molecular Basis of FertilizationAnnual Review of Biochemistry1989226
22Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disordersNature Reviews Drug Discovery2014226
23Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporterJournal of Comparative Neurology2000225
24Novel Selective Allosteric Activator of the M1Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in RatsJournal of Neuroscience2008219
25Drugs for Allosteric Sites on ReceptorsAnnual Review of Pharmacology and Toxicology2014218
26A Selective Allosteric Potentiator of the M1Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal LearningJournal of Neuroscience2009217
27The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonistProstaglandins1992214
28Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug DiscoveryJournal of Medicinal Chemistry2012212
29The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disordersJournal of Clinical Investigation2009203
30A Primary Culture System for Functional Analysis of C. elegans Neurons and Muscle CellsNeuron2002202
31mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial LearningNeuropsychopharmacology2009199
32How activated receptors couple to G proteinsProceedings of the National Academy of Sciences of the United States of America2001196
33MEMBRANETRAFFICKING OFG PROTEIN–COUPLEDRECEPTORSAnnual Review of Pharmacology and Toxicology2004194
34How and why do GPCRs dimerize?Trends in Pharmacological Sciences2008192
35Role of Astrocytes in Brain Function and DiseaseToxicologic Pathology2011192
36GPCR monomers and oligomers: it takes all kindsTrends in Neurosciences2008187
37Enhanced Arrestin Facilitates Recovery and Protects Rods Lacking Rhodopsin PhosphorylationCurrent Biology2009178
38Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL ProteaseJournal of Medicinal Chemistry2013178
39Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in RatsJournal of Pharmacology and Experimental Therapeutics2008177
40Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic ActivityMolecular Pharmacology2010176
41Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1*Journal of Biological Chemistry2005173
42Brain Regional Quantification of F-Ring and D-/E-Ring Isoprostanes and Neuroprostanes in Alzheimer’s DiseaseAmerican Journal of Pathology2001167
43Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunitBiochemical Journal1999165
44A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic ActivityJournal of Pharmacology and Experimental Therapeutics2005165
45Phenotype risk scores identify patients with unrecognized Mendelian disease patternsScience2018164
46Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in MiceJournal of Pharmacology and Experimental Therapeutics2006162
47Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III ReceptorJournal of Biological Chemistry2008161
48Oscillatory Ca2+ Signaling in the Isolated Caenorhabditis elegans IntestineJournal of General Physiology2005158
49Tyr-95 and Ile-172 in Transmembrane Segments 1 and 3 of Human Serotonin Transporters Interact to Establish High Affinity Recognition of AntidepressantsJournal of Biological Chemistry2006158
50Mechanism of potassium-channel selectivity revealed by Na+ and Li+ binding sites within the KcsA poreNature Structural and Molecular Biology2009158