| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas | Gastroenterology | 1994 | 2,329 |
| 3 | Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells | Cell | 1998 | 2,151 |
| 4 | Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2 | Cell | 1995 | 2,144 |
| 5 | Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Critical Care Medicine | 2018 | 2,074 |
| 6 | SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues | Cell | 2020 | 1,956 |
| 7 | Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease | Nature Reviews Clinical Oncology | 2016 | 1,938 |
| 8 | Updated Clinical Classification of Pulmonary Hypertension | Journal of the American College of Cardiology | 2009 | 1,919 |
| 9 | Reassessment of Exosome Composition | Cell | 2019 | 1,786 |
| 10 | Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer | Cell | 2018 | 1,718 |
| 11 | Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors | JAMA Oncology | 2018 | 1,625 |
| 12 | The role of cyclooxygenases in inflammation, cancer, and development | Oncogene | 1999 | 1,289 |
| 13 | Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 1,280 |
| 14 | Helicobacter pyloriand Gastric Cancer: Factors That Modulate Disease Risk | Clinical Microbiology Reviews | 2010 | 1,118 |
| 15 | COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options | Cardiovascular Research | 2020 | 1,074 |
| 16 | Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 | Nature Reviews Cancer | 2001 | 989 |
| 17 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 18 | Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial | Science | 2022 | 788 |
| 19 | Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics | Nature Communications | 2018 | 748 |
| 20 | Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study | Lancet Oncology, The | 2018 | 742 |
| 21 | Angiotensin-Converting Enzyme Inhibitors | Circulation | 1998 | 687 |
| 22 | Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors | | 2019 | 642 |
| 23 | Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis | Lancet, The | 2018 | 618 |
| 24 | Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis | Nature Medicine | 2001 | 616 |
| 25 | Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells | Journal of Biological Chemistry | 1997 | 613 |
| 26 | Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2 | Nature | 2007 | 613 |
| 27 | Inflammation, Growth Factors, and Pulmonary Vascular Remodeling | Journal of the American College of Cardiology | 2009 | 605 |
| 28 | Host cyclooxygenase-2 modulates carcinoma growth | Journal of Clinical Investigation | 2000 | 601 |
| 29 | The Outcome of Neutrophil Gelatinase-Associated Lipocalin-Positive Subclinical Acute Kidney Injury | Journal of the American College of Cardiology | 2011 | 597 |
| 30 | The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor | Cell | 2012 | 580 |
| 31 | Mechanisms of receptor tyrosine kinase activation in cancer | Molecular Cancer | 2018 | 580 |
| 32 | Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis | Science Advances | 2020 | 571 |
| 33 | Multi-ethnic genome-wide association study for atrial fibrillation | Nature Genetics | 2018 | 552 |
| 34 | Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics | Gastroenterology | 2006 | 542 |
| 35 | Ipilimumab Therapy in Patients With Advanced Melanoma and Preexisting Autoimmune Disorders | JAMA Oncology | 2016 | 534 |
| 36 | Detectable clonal mosaicism and its relationship to aging and cancer | Nature Genetics | 2012 | 519 |
| 37 | The gastric precancerous cascade | Journal of Digestive Diseases | 2012 | 512 |
| 38 | COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study | Lancet Oncology, The | 2020 | 503 |
| 39 | Exome-wide association study of plasma lipids in >300,000 individuals | Nature Genetics | 2017 | 470 |
| 40 | Efferocytosis in health and disease | Nature Reviews Immunology | 2020 | 461 |
| 41 | Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity | JAMA - Journal of the American Medical Association | 2021 | 458 |
| 42 | MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation | Cell Metabolism | 2017 | 449 |
| 43 | Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors | Annals of Oncology | 2018 | 449 |
| 44 | Patient Understanding of Food Labels | American Journal of Preventive Medicine | 2006 | 447 |
| 45 | Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism | Cell | 2018 | 445 |
| 46 | A brief history of human disease genetics | Nature | 2020 | 441 |
| 47 | A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke | Nature Genetics | 2009 | 434 |
| 48 | Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS | Molecular and Cellular Proteomics | 2013 | 431 |
| 49 | Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade | JAMA Oncology | 2019 | 431 |
| 50 | Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade | Cancer Immunology Research | 2016 | 428 |
