| # | Title | Journal | Year | Citations |
|---|
| 1 | Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases | Circulation Research | 2003 | 3,960 |
| 2 | Host-Gut Microbiota Metabolic Interactions | Science | 2012 | 3,693 |
| 3 | Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) | Science | 2020 | 2,940 |
| 4 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 5 | Structure and function of matrix metalloproteinases and TIMPs | Cardiovascular Research | 2006 | 2,620 |
| 6 | Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study | BMJ, The | 2020 | 2,474 |
| 7 | Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6 | Science | 2009 | 2,295 |
| 8 | TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis | Science | 2008 | 2,268 |
| 9 | The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway | Schizophrenia Bulletin | 2009 | 2,149 |
| 10 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 11 | Strategies for mitigating an influenza pandemic | Nature | 2006 | 1,863 |
| 12 | Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts | Nature Protocols | 2007 | 1,830 |
| 13 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 14 | The gut microbiota and host health: a new clinical frontier | Gut | 2016 | 1,719 |
| 15 | Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings | Science | 2009 | 1,665 |
| 16 | Strategies for containing an emerging influenza pandemic in Southeast Asia | Nature | 2005 | 1,592 |
| 17 | Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) | Intensive Care Medicine | 2020 | 1,536 |
| 18 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence | Cell | 2008 | 1,446 |
| 19 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 20 | Common genetic determinants of vitamin D insufficiency: a genome-wide association study | Lancet, The | 2010 | 1,385 |
| 21 | Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology | Gut | 2016 | 1,379 |
| 22 | The Oslo definitions for coeliac disease and related terms | Gut | 2013 | 1,300 |
| 23 | Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease | Nature Medicine | 2003 | 1,244 |
| 24 | JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework | Nucleic Acids Research | 2018 | 1,232 |
| 25 | Senescence surveillance of pre-malignant hepatocytes limits liver cancer development | Nature | 2011 | 1,208 |
| 26 | Guidelines for the welfare and use of animals in cancer research | British Journal of Cancer | 2010 | 1,167 |
| 27 | The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism | Nature Communications | 2014 | 1,129 |
| 28 | IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses | Nature Immunology | 2011 | 1,068 |
| 29 | Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 | Nature Immunology | 2020 | 1,066 |
| 30 | Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice | Nature | 2003 | 1,049 |
| 31 | Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe | Human Brain Mapping | 2003 | 1,040 |
| 32 | JASPAR 2020: update of the open-access database of transcription factor binding profiles | Nucleic Acids Research | 2020 | 1,039 |
| 33 | Cholangiocarcinoma | Lancet, The | 2005 | 1,029 |
| 34 | Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells | Blood | 2005 | 1,026 |
| 35 | The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity | Biochimica Et Biophysica Acta - Molecular Cell Research | 2010 | 1,026 |
| 36 | Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor | Science | 2013 | 1,012 |
| 37 | Transmission Dynamics of the Etiological Agent of SARS in Hong Kong: Impact of Public Health Interventions | Science | 2003 | 1,004 |
| 38 | Impact of the gut microbiota on inflammation, obesity, and metabolic disease | Genome Medicine | 2016 | 1,000 |
| 39 | Symbiotic gut microbes modulate human metabolic phenotypes | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 994 |
| 40 | Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study | Lancet Psychiatry,the | 2016 | 988 |
| 41 | In-vivo measurement of activated microglia in dementia | Lancet, The | 2001 | 983 |
| 42 | In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease | Neurobiology of Disease | 2006 | 982 |
| 43 | Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism | Nature Reviews Drug Discovery | 2003 | 975 |
| 44 | Human metabolic phenotype diversity and its association with diet and blood pressure | Nature | 2008 | 966 |
| 45 | Long covid—mechanisms, risk factors, and management | BMJ, The | 2021 | 946 |
| 46 | Salt intakes around the world: implications for public health | International Journal of Epidemiology | 2009 | 928 |
| 47 | The 2019 report of The Lancet Countdown on health and climate change: ensuring that the health of a child born today is not defined by a changing climate | Lancet, The | 2019 | 905 |
| 48 | Chronic Myeloid Leukemia — Advances in Biology and New Approaches to Treatment | New England Journal of Medicine | 2003 | 875 |
| 49 | Global metabolic profiling procedures for urine using UPLC–MS | Nature Protocols | 2010 | 867 |
| 50 | ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma | International Journal of Gynecological Cancer | 2021 | 859 |
