| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 2 | Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections | Nature Genetics | 2007 | 767 |
| 3 | Multicollinearity in Regression Analyses Conducted in Epidemiologic Studies | Epidemiology (Sunnyvale, Calif ) | 2016 | 515 |
| 4 | TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome | Nature Genetics | 2012 | 319 |
| 5 | Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms | Circulation Research | 2011 | 258 |
| 6 | Identification of the Activating and Conjugating Enzymes of the NEDD8 Conjugation Pathway | Journal of Biological Chemistry | 1999 | 232 |
| 7 | Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding | Blood | 2006 | 232 |
| 8 | Vulnerable Atherosclerotic Plaque | Circulation | 2003 | 224 |
| 9 | De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction | American Journal of Medical Genetics, Part A | 2010 | 217 |
| 10 | Asprosin is a centrally acting orexigenic hormone | Nature Medicine | 2017 | 216 |
| 11 | The Effect of Nonsurgical Periodontal Therapy on Hemoglobin A1cLevels in Persons With Type 2 Diabetes and Chronic Periodontitis | JAMA - Journal of the American Medical Association | 2013 | 211 |
| 12 | A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk | Cell | 2013 | 209 |
| 13 | Association of Telemedicine for Remote Monitoring of Intensive Care Patients With Mortality, Complications, and Length of Stay | JAMA - Journal of the American Medical Association | 2009 | 203 |
| 14 | Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections | American Journal of Human Genetics | 2013 | 197 |
| 15 | Inducible Cyclooxygenase and Nitric Oxide Synthase | Advances in Pharmacology | 1995 | 191 |
| 16 | Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection | Journal of the American College of Cardiology | 2018 | 190 |
| 17 | Synergistic Effect of Urotensin II With Mildly Oxidized LDL on DNA Synthesis in Vascular Smooth Muscle Cells | Circulation | 2001 | 189 |
| 18 | Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1 | Nature Genetics | 2011 | 188 |
| 19 | Interstitial lung disease with autoantibodies againstaminoacyl-tRNA synthetases in the absence of clinically apparent myositis | Seminars in Arthritis and Rheumatism | 1996 | 187 |
| 20 | Detrimental effects of adenosine signaling in sickle cell disease | Nature Medicine | 2011 | 172 |
| 21 | Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association–European Society of Cardiology | European Heart Journal | 2018 | 171 |
| 22 | Point: Vancomycin Is Not Obsolete for the Treatment of Infection Caused by Methicillin-Resistant Staphylococcus aureus | Clinical Infectious Diseases | 2007 | 163 |
| 23 | A Roadmap to Investigate the Genetic Basis of Bicuspid Aortic Valve and its Complications | Journal of the American College of Cardiology | 2014 | 162 |
| 24 | Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice | Science Translational Medicine | 2017 | 162 |
| 25 | Cardiac Metabolism as a Target for the Treatment of Heart Failure | Circulation | 2004 | 154 |
| 26 | CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion | EMBO Journal | 2012 | 148 |
| 27 | Pulmonary complications in chronic liver disease | Hepatology | 2014 | 144 |
| 28 | Interaction Between Nitric Oxide and Prostaglandin H Synthase | Archives of Biochemistry and Biophysics | 1994 | 137 |
| 29 | The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria | Histochemistry and Cell Biology | 2012 | 136 |
| 30 | Innate Host Defense of the Lung: Effects of Lung-lining Fluid pH | Lung | 2004 | 135 |
| 31 | Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats | Biochemical Journal | 2007 | 135 |
| 32 | Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE | Critical Care | 2016 | 129 |
| 33 | Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations | Arthritis Research and Therapy | 2009 | 128 |
| 34 | Protection of Endothelial Survival by Peroxisome Proliferator-Activated Receptor-δ Mediated 14-3-3 Upregulation | Arteriosclerosis, Thrombosis, and Vascular Biology | 2006 | 125 |
| 35 | Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase) | American Journal of Medicine | 1990 | 123 |
| 36 | Bicuspid aortic valve aortopathy in adults: Incidence, etiology, and clinical significance | International Journal of Cardiology | 2015 | 122 |
| 37 | Analysis of Hydroperoxide-Induced Tyrosyl Radicals and Lipoxygenase Activity in Aspirin-Treated Human Prostaglandin H Synthase-2† | Biochemistry | 1997 | 120 |
| 38 | Spectrum of Aortic Operations in 300 Patients With Confirmed or Suspected Marfan Syndrome | Annals of Thoracic Surgery | 2006 | 120 |
| 39 | Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes | Thrombosis Research | 2009 | 119 |
| 40 | Cyclooxygenase 2 induction: Molecular mechanism and pathophysiologic roles | Translational Research | 1996 | 116 |
| 41 | Spectroscopic Evidence for Reaction of Prostaglandin H Synthase-1 Tyrosyl Radical with Arachidonic Acid | Journal of Biological Chemistry | 1995 | 115 |
| 42 | Characterization of a Second Member of the Sentrin Family of Ubiquitin-like Proteins | Journal of Biological Chemistry | 1998 | 112 |
| 43 | Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine | British Journal of Cancer | 2010 | 112 |
| 44 | Coagulation factor VA2440G causes east Texas bleeding disorder via TFPIα | Journal of Clinical Investigation | 2013 | 111 |
| 45 | Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches | Vascular Pharmacology | 2017 | 111 |
| 46 | Comprehensive Characterization of Alternative Polyadenylation in Human Cancer | Journal of the National Cancer Institute | 2018 | 111 |
| 47 | MFAP5 Loss-of-Function Mutations Underscore the Involvement of Matrix Alteration in the Pathogenesis of Familial Thoracic Aortic Aneurysms and Dissections | American Journal of Human Genetics | 2014 | 110 |
| 48 | Structure of the Elastin-Contractile Units in the Thoracic Aorta and How Genes That Cause Thoracic Aortic Aneurysms and Dissections Disrupt This Structure | Canadian Journal of Cardiology | 2016 | 110 |
| 49 | Clinical correlates and mortality impact of left ventricular hypertrophy among new ESRD patients in the United States | American Journal of Kidney Diseases | 2002 | 108 |
| 50 | Nitric Oxide-Loaded Echogenic Liposomes for Nitric Oxide Delivery and Inhibition of Intimal Hyperplasia | Journal of the American College of Cardiology | 2009 | 108 |
