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Top Articles

#TitleJournalYearCitations
1The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pHMolecular Therapy2013593
2Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current statusJournal of Chemical Biology2010530
3Fluorescence quenching and ligand binding: A critical discussion of a popular methodologyJournal of Molecular Structure2011513
4Coamorphous Drug Systems: Enhanced Physical Stability and Dissolution Rate of Indomethacin and NaproxenMolecular Pharmaceutics2011302
5Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestineBiochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids2008281
6A review of independent action compared to concentration addition as reference models for mixtures of compounds with different molecular target sitesEnvironmental Toxicology and Chemistry2008272
7New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugsJournal of Pharmacy and Pharmacology2010246
8Intra‐articular depot formulation principles: Role in the management of postoperative pain and arthritic disordersJournal of Pharmaceutical Sciences2008244
9Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issuesNanomedicine: Nanotechnology, Biology, and Medicine2011240
10Solid form screening – A reviewEuropean Journal of Pharmaceutics and Biopharmaceutics2009237
11Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen–cimetidine mixtures prepared by mechanical activationJournal of Controlled Release2009236
12Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent processMolecular Immunology2008231
13A Helical Structural Nucleus Is the Primary Elongating Unit of Insulin Amyloid FibrilsPLoS Biology2007229
14Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratoriesEuropean Journal of Pharmaceutical Sciences2008220
15Forced Degradation of Therapeutic ProteinsJournal of Pharmaceutical Sciences2012207
16Protein Adsorption at Charged Surfaces: The Role of Electrostatic Interactions and Interfacial Charge RegulationLangmuir2011205
17Hyaluronan-coated nanoparticles: The influence of the molecular weight on CD44-hyaluronan interactions and on the immune responseJournal of Controlled Release2011204
18Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactionsEuropean Journal of Pharmaceutics and Biopharmaceutics2012197
19Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinicAdvanced Drug Delivery Reviews2009195
20Binding mode of Thioflavin T in insulin amyloid fibrilsJournal of Structural Biology2007193
21Polycation cytotoxicity: a delicate matter for nucleic acid therapy—focus on polyethylenimineSoft Matter2010193
22High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: Quality by design optimization and characterizationEuropean Journal of Pharmaceutics and Biopharmaceutics2011191
23Fluorescence Quenching to Study Protein-ligand Binding: Common ErrorsJournal of Fluorescence2010186
24Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effectsEuropean Neuropsychopharmacology2008185
25Cell-penetrating peptides for drug delivery across membrane barriersExpert Opinion on Drug Delivery2008177
26Spray drying of siRNA-containing PLGA nanoparticles intended for inhalationJournal of Controlled Release2010176
27Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNAJournal of Controlled Release2012162
28Complement activation cascade triggered by PEG–PL engineered nanomedicines and carbon nanotubes: The challenges aheadJournal of Controlled Release2010157
29Gold-embedded photosensitive liposomes for drug delivery: Triggering mechanism and intracellular releaseJournal of Controlled Release2010140
30Design space approach in the optimization of the spray-drying processEuropean Journal of Pharmaceutics and Biopharmaceutics2012138
31Analysis of Secondary Plant Metabolites by Indirect Desorption Electrospray Ionization Imaging Mass SpectrometryAnalytical Chemistry2011137
32Near-infrared chemical imaging (NIR-CI) on pharmaceutical solid dosage forms—Comparing common calibration approachesJournal of Pharmaceutical and Biomedical Analysis2008134
33Metabolic activation of carboxylic acidsExpert Opinion on Drug Metabolism and Toxicology2008131
34Precipitation of a Poorly Soluble Model Drug during In Vitro Lipolysis: Characterization and Dissolution of the PrecipitateJournal of Pharmaceutical Sciences2010131
35In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systemsInternational Journal of Pharmaceutics2011126
36Is Glutathione the Major Cellular Target of Cisplatin? A Study of the Interactions of Cisplatin with Cancer Cell ExtractsJournal of Medicinal Chemistry2009125
37Morphological observations on a lipid-based drug delivery system during in vitro digestionEuropean Journal of Pharmaceutical Sciences2007124
38On-chip electro membrane extractionMicrofluidics and Nanofluidics2010121
39Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studiesJournal of Pharmacy and Pharmacology2010119
40Quality by design – Spray drying of insulin intended for inhalationEuropean Journal of Pharmaceutics and Biopharmaceutics2008117
41Cationic carriers of genetic material and cell death: A mitochondrial taleBiochimica Et Biophysica Acta - Bioenergetics2010117
42Subunit vaccines of the future: the need for safe, customized and optimized particulate delivery systemsTherapeutic Delivery2011116
43Production and characterization of poly(3-hydroxypropionate-co-4-hydroxybutyrate) with fully controllable structures by recombinant Escherichia coli containing an engineered pathwayMetabolic Engineering2012116
44Stabilization of liposomes during dryingExpert Opinion on Drug Delivery2011114
45Cu(II) Mediates Kinetically Distinct, Non-amyloidogenic Aggregation of Amyloid-β PeptidesJournal of Biological Chemistry2011114
46Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensorFASEB Journal2011114
47Development and Evaluation of an Electrochemical Method for Studying Reactive Phase-I Metabolites:  Correlation to in Vitro Drug MetabolismChemical Research in Toxicology2007112
48In vitro digestion testing of lipid-based delivery systems: Calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion productsInternational Journal of Pharmaceutics2013112
49Recent trends in stabilising peptides and proteins in pharmaceutical formulation – considerations in the choice of excipientsExpert Opinion on Drug Delivery2009107
50Synthesis of Diblock copolymer poly-3-hydroxybutyrate -block-poly-3-hydroxyhexanoate [PHB-b-PHHx] by a β-oxidation weakened Pseudomonas putida KT2442Microbial Cell Factories2012105