| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 | Modern Rheumatology | 2012 | 1,294 |
| 3 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 | Modern Rheumatology | 2012 | 947 |
| 4 | A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application | Nature Immunology | 2013 | 783 |
| 5 | Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake | Cell Metabolism | 2007 | 701 |
| 6 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details | Modern Rheumatology | 2012 | 662 |
| 7 | Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal | Journal of Gastroenterology | 2006 | 549 |
| 8 | Cancer immunotherapies targeting the PD-1 signaling pathway | Journal of Biomedical Science | 2017 | 501 |
| 9 | Tokyo Guidelines 2018: flowchart for the management of acute cholecystitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 470 |
| 10 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details | Modern Rheumatology | 2012 | 453 |
| 11 | Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis | Journal of Gastroenterology | 2008 | 418 |
| 12 | Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial | Lancet, The | 2018 | 396 |
| 13 | Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 387 |
| 14 | MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling | Cell | 2012 | 371 |
| 15 | Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle | Cell Metabolism | 2011 | 362 |
| 16 | Peripheral Lung Adenocarcinoma: Correlation of Thin-Section CT Findings with Histologic Prognostic Factors and Survival | Radiology | 2001 | 352 |
| 17 | Janus kinase inhibitors in autoimmune diseases | Annals of the Rheumatic Diseases | 2013 | 350 |
| 18 | Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015 | Journal of Hepato-Biliary-Pancreatic Sciences | 2015 | 332 |
| 19 | Degradation of Interleukin 1β by Matrix Metalloproteinases | Journal of Biological Chemistry | 1996 | 326 |
| 20 | Osteoblasts and Osteoclasts in Bone Remodeling and Inflammation | Inflammation and Allergy: Drug Targets | 2005 | 321 |
| 21 | Japanese 2011 guidelines for prevention and treatment of osteoporosis—executive summary | Archives of Osteoporosis | 2012 | 284 |
| 22 | Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system | Annals of the Rheumatic Diseases | 2006 | 282 |
| 23 | Tokyo Guidelines 2018: surgical management of acute cholecystitis: safe steps in laparoscopic cholecystectomy for acute cholecystitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 281 |
| 24 | Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside | Annals of Neurology | 2001 | 280 |
| 25 | Efficacy and safety of tocilizumab in patients with refractory Takayasu arteritis: results from a randomised, double-blind, placebo-controlled, phase 3 trial in Japan (the TAKT study) | Annals of the Rheumatic Diseases | 2018 | 279 |
| 26 | Centrally administered orexin/hypocretin activates HPA axis in rats | NeuroReport | 2000 | 267 |
| 27 | The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation | Cytokine | 2011 | 262 |
| 28 | Phase II study of tofacitinib (CP‐690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate | Arthritis Care and Research | 2011 | 259 |
| 29 | Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis: RRR (remission induction by Remicade in RA) study | Annals of the Rheumatic Diseases | 2010 | 251 |
| 30 | Clear Cell Sarcoma of Soft Tissue | American Journal of Surgical Pathology | 2008 | 250 |
| 31 | Normal Range of Left Ventricular 2-Dimensional Strain | Circulation Journal | 2012 | 244 |
| 32 | Recent Advances in Structural Research on Ether Lipids from Archaea Including Comparative and Physiological Aspects | Bioscience, Biotechnology and Biochemistry | 2005 | 243 |
| 33 | Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 242 |
| 34 | TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2013 | 236 |
| 35 | Pancreatic Ductal Adenocarcinoma Derived From IPMN and Pancreatic Ductal Adenocarcinoma Concomitant With IPMN | Pancreas | 2011 | 235 |
| 36 | Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions | Annals of the Rheumatic Diseases | 2016 | 232 |
| 37 | Nonalcoholic Fatty Liver Disease Is a Risk Factor for Type 2 Diabetes in Middle-Aged Japanese Men | Diabetes Care | 2007 | 226 |
| 38 | TG13: Updated Tokyo Guidelines for the management of acute cholangitis and cholecystitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2013 | 222 |
| 39 | Tokyo Guidelines 2018: management strategies for gallbladder drainage in patients with acute cholecystitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 220 |
| 40 | Relationship between fluctuations in glucose levels measured by continuous glucose monitoring and vascular endothelial dysfunction in type 2 diabetes mellitus | Cardiovascular Diabetology | 2013 | 215 |
| 41 | Central control of fever and female body temperature by RANKL/RANK | Nature | 2009 | 212 |
| 42 | REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy | CNS Neuroscience and Therapeutics | 2010 | 209 |
| 43 | Immunocytochemical markers of uncommon pancreatic tumors. Acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor | Cancer | 1987 | 208 |
| 44 | New diagnostic criteria and severity assessment of acute cholangitis in revised Tokyo guidelines | Journal of Hepato-Biliary-Pancreatic Sciences | 2012 | 205 |
| 45 | Subclinical left ventricular dysfunction in asymptomatic diabetic patients assessed by two-dimensional speckle tracking echocardiography: correlation with diabetic duration | European Journal of Echocardiography | 2009 | 203 |
| 46 | Interstitial Pneumonia Associated with Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis | Respiration | 2013 | 199 |
| 47 | Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care | Journal of Magnetic Resonance Imaging | 2017 | 199 |
| 48 | Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach | Nature Reviews Rheumatology | 2022 | 193 |
| 49 | Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway | Nature Medicine | 2004 | 191 |
| 50 | JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis | Journal of Hepato-Biliary-Pancreatic Surgery | 2006 | 190 |
