| # | Title | Journal | Year | Citations |
|---|
| 1 | Nuclear factor-κB in cancer development and progression | Nature | 2006 | 3,219 |
| 2 | NF-κB: linking inflammation and immunity to cancer development and progression | Nature Reviews Immunology | 2005 | 2,745 |
| 3 | Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer | Cell | 2006 | 835 |
| 4 | Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling | Nature | 2011 | 583 |
| 5 | A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches | Gastroenterology | 2012 | 414 |
| 6 | Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription | Cell | 2013 | 380 |
| 7 | Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway | Journal of Biological Chemistry | 1997 | 370 |
| 8 | c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK | Nature | 1994 | 349 |
| 9 | Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring | Nature | 2019 | 287 |
| 10 | An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers | Cancer Cell | 2016 | 237 |
| 11 | NOD2 and Crohn’s Disease: Loss or Gain of Function? | Immunity | 2005 | 178 |
| 12 | Myosin VIIa, the product of the Usher 1B syndrome gene, is concentrated in the connecting cilia of photoreceptor cells | Cytoskeleton | 1997 | 171 |
| 13 | Immune Infiltration and Prostate Cancer | Frontiers in Oncology | 2015 | 161 |
| 14 | Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist | Nature Chemical Biology | 2018 | 155 |
| 15 | Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling | Molecular and Cellular Biology | 2003 | 154 |
| 16 | AP-1--glucocorticoid receptor crosstalk taken to a higher level | Journal of Endocrinology | 2001 | 145 |
| 17 | Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes | Journal of Cell Science | 2004 | 137 |
| 18 | Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane | Nature | 2020 | 128 |
| 19 | Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations | Nature Communications | 2018 | 126 |
| 20 | Measurement of Molecular Interactions in Living Cells by Fluorescence Resonance Energy Transfer Between Variants of the Green Fluorescent Protein | Science Signaling | 2000 | 122 |
| 21 | Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia | Nature Genetics | 2014 | 97 |
| 22 | Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling | Cell | 2021 | 97 |
| 23 | Rules of Engagement: GPCRs and G Proteins | ACS Pharmacology and Translational Science | 2018 | 93 |
| 24 | CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia | Cancer Cell | 2016 | 86 |
| 25 | Isolation of a cDNA Encoding a Metal Response Element Binding Protein Using a Novel Expression Cloning Procedure: The One Hybrid System | DNA and Cell Biology | 1994 | 77 |
| 26 | Multicenter Evaluation of the Clinical Outcomes of Daptomycin with and without Concomitant β-Lactams in Patients with Staphylococcus aureus Bacteremia and Mild to Moderate Renal Impairment | Antimicrobial Agents and Chemotherapy | 2013 | 77 |
| 27 | Actin-based motor properties of native myosin VIIa | Journal of Cell Science | 2002 | 71 |
| 28 | Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration | Genes and Development | 2014 | 69 |
| 29 | Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia | Proceedings of the National Academy of Sciences of the United States of America | 2021 | 69 |
| 30 | Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR | Cell Research | 2021 | 65 |
| 31 | Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 64 |
| 32 | Acute Vascular Disruption and Aquaporin 4 Loss After Stroke | Stroke | 2009 | 62 |
| 33 | Actin-based motor properties of native myosin VIIa | Journal of Cell Science | 2002 | 59 |
| 34 | Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia | Cell Stem Cell | 2015 | 58 |
| 35 | Structure-based discovery of selective positive allosteric modulators of antagonists for the M 2 muscarinic acetylcholine receptor | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 57 |
| 36 | Butyrylcholinesterase: Association with the Metabolic Syndrome and Identification of 2 Gene Loci Affecting Activity | Clinical Chemistry | 2006 | 56 |
| 37 | The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65 | Human Molecular Genetics | 2011 | 56 |
| 38 | Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2 | Carcinogenesis | 2016 | 55 |
| 39 | An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor | Nature Chemical Biology | 2020 | 51 |
| 40 | Function of MYO7A in the Human RPE and the Validity of Shaker1 Mice as a Model for Usher Syndrome 1B | | 2010 | 40 |
| 41 | Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor | ELife | 2018 | 40 |
| 42 | Aequorea’s secrets revealed: New fluorescent proteins with unique properties for bioimaging and biosensing | PLoS Biology | 2020 | 40 |
| 43 | Isolation and Culture of Primary Mouse Retinal Pigmented Epithelial Cells | Advances in Experimental Medicine and Biology | 2003 | 38 |
| 44 | Defective phototransductive disk membrane morphogenesis in transgenic mice expressing opsin with a mutated N-terminal domain | Journal of Cell Science | 1997 | 38 |
| 45 | Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug | Cell Reports | 2021 | 38 |
| 46 | Structure and selectivity engineering of the M 1 muscarinic receptor toxin complex | Science | 2020 | 35 |
| 47 | Clinical Outcomes of Daptomycin for Vancomycin-resistant Enterococcus Bacteremia | Clinical Therapeutics | 2015 | 34 |
| 48 | Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke | Journal of Cerebral Blood Flow and Metabolism | 2017 | 34 |
| 49 | Proteomic Analysis of Mature Melanosomes from the Retinal Pigmented Epithelium | Journal of Proteome Research | 2006 | 32 |
| 50 | Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis? | Journal of Clinical Medicine | 2019 | 32 |
