| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer | Cancer Cell | 2009 | 1,851 |
| 3 | Leptospirosis: a zoonotic disease of global importance | Lancet Infectious Diseases, The | 2003 | 1,828 |
| 4 | Signaling Pathways for Cardiac Hypertrophy and Failure | New England Journal of Medicine | 1999 | 790 |
| 5 | Toll‐like receptors and adaptor molecules in liver disease: Update | Hepatology | 2008 | 614 |
| 6 | Logistic regression in the medical literature: | Journal of Clinical Epidemiology | 2001 | 511 |
| 7 | Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 500 |
| 8 | Varicella zoster virus infection | Nature Reviews Disease Primers | 2015 | 435 |
| 9 | Chronic major-vessel thromboembolic pulmonary hypertension. | Circulation | 1990 | 431 |
| 10 | Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor | Nature | 1995 | 431 |
| 11 | Gout | New England Journal of Medicine | 2003 | 427 |
| 12 | Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity | Journal of Allergy and Clinical Immunology | 2000 | 382 |
| 13 | Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae | Nature | 2001 | 336 |
| 14 | Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation | Blood | 1995 | 293 |
| 15 | Probiotics and Commensals Reverse TNF-α– and IFN-γ–Induced Dysfunction in Human Intestinal Epithelial Cells | Gastroenterology | 2006 | 278 |
| 16 | Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α | Blood | 2005 | 270 |
| 17 | “Coaching Boys into Men”: A Cluster-Randomized Controlled Trial of a Dating Violence Prevention Program | Journal of Adolescent Health | 2012 | 270 |
| 18 | Ventricular muscle-restricted targeting of the RXRα gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis | Development (Cambridge) | 1998 | 265 |
| 19 | Initiation and regulation of tissue factor-dependent blood coagulation. | Arteriosclerosis and Thrombosis: A Journal of Vascular Biology | 1992 | 255 |
| 20 | What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira | PLoS Neglected Tropical Diseases | 2016 | 253 |
| 21 | Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 246 |
| 22 | Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice | Hepatology | 2013 | 242 |
| 23 | A Nuclear Hormone Receptor Corepressor Mediates Transcriptional Silencing by Receptors with Distinct Repression Domains | Molecular and Cellular Biology | 1996 | 226 |
| 24 | Recommendations for Diagnosis, Referral for Liver Biopsy, and Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis | Mayo Clinic Proceedings | 2015 | 214 |
| 25 | Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. | Journal of Clinical Investigation | 1998 | 209 |
| 26 | Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 207 |
| 27 | The Accuracy of Drug Information From Pharmaceutical Sales Representatives | JAMA - Journal of the American Medical Association | 1995 | 204 |
| 28 | Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein | Journal of Virology | 1996 | 203 |
| 29 | Diverse virulence traits underlying different clinical outcomes of Salmonella infection | Journal of Clinical Investigation | 2001 | 190 |
| 30 | Acquired CD40-ligand deficiency in chronic lymphocytic leukemia | Nature Medicine | 1997 | 186 |
| 31 | Determining Risk for Severe Leptospirosis by Molecular Analysis of Environmental Surface Waters for Pathogenic Leptospira | PLoS Medicine | 2006 | 180 |
| 32 | Cardiac-Myocyte-Specific Excision of the Vinculin Gene Disrupts Cellular Junctions, Causing Sudden Death or Dilated Cardiomyopathy | Molecular and Cellular Biology | 2007 | 179 |
| 33 | NOD2 and Crohn’s Disease: Loss or Gain of Function? | Immunity | 2005 | 178 |
| 34 | Genetic approaches identify adult pituitary stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 176 |
| 35 | CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice | Hepatology | 2010 | 163 |
| 36 | Longitudinal Study of Cytomegalovirus Retinitis in Acquired Immune Deficiency Syndrome | Ophthalmology | 1990 | 160 |
| 37 | Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. | Journal of Clinical Investigation | 1988 | 155 |
| 38 | Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model | PLoS ONE | 2013 | 147 |
| 39 | mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT | Molecular Cell | 2017 | 147 |
| 40 | Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease | American Journal of Respiratory and Critical Care Medicine | 2019 | 145 |
| 41 | Management of genitourinary syndrome of menopause in women with or at high risk for breast cancer: consensus recommendations from The North American Menopause Society and The International Society for the Study of Women's Sexual Health | Menopause | 2018 | 143 |
| 42 | FOXO animal models reveal a variety of diverse roles for FOXO transcription factors | Oncogene | 2008 | 140 |
| 43 | High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission | Cell Host and Microbe | 2016 | 140 |
| 44 | Innate immunity and antimicrobial defense systems in psoriasis | Clinics in Dermatology | 2007 | 138 |
| 45 | Endosomal localization and function of sorting nexin 1 | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 137 |
| 46 | Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells | Journal of Molecular and Cellular Cardiology | 1990 | 135 |
| 47 | Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 135 |
| 48 | Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rattus Species Reservoir in the Peruvian Amazon | PLoS Neglected Tropical Diseases | 2008 | 134 |
| 49 | Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling | Cell Metabolism | 2019 | 130 |
| 50 | Clonal changes in inflammatory pseudotumor of the lung. A case report | Cancer | 1995 | 125 |
