| # | Title | Journal | Year | Citations |
|---|
| 1 | Trends in GPCR drug discovery: new agents, targets and indications | Nature Reviews Drug Discovery | 2017 | 1,773 |
| 2 | Structural diversity of G protein-coupled receptors and significance for drug discovery | Nature Reviews Drug Discovery | 2008 | 1,251 |
| 3 | Analyses of pig genomes provide insight into porcine demography and evolution | Nature | 2012 | 1,190 |
| 4 | Irreversible motor impairment in young addicts ? ephedrone, manganism or both? | Acta Neurologica Scandinavica | 2007 | 1,023 |
| 5 | The Genome of the Sea Urchin Strongylocentrotus purpuratus | Science | 2006 | 1,018 |
| 6 | Whole-genome resequencing reveals loci under selection during chicken domestication | Nature | 2010 | 985 |
| 7 | ER stress and neurodegenerative diseases | Cell Death and Differentiation | 2006 | 762 |
| 8 | HMDB 5.0: the Human Metabolome Database for 2022 | Nucleic Acids Research | 2022 | 736 |
| 9 | Trends in the exploitation of novel drug targets | Nature Reviews Drug Discovery | 2011 | 720 |
| 10 | The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes | Molecular Pharmacology | 2005 | 518 |
| 11 | Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin | BMC Biology | 2009 | 497 |
| 12 | Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology | JAMA Neurology | 2019 | 455 |
| 13 | Internet-based self-help for depression: randomised controlled trial | British Journal of Psychiatry | 2005 | 431 |
| 14 | Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence | CNS Drugs | 2013 | 402 |
| 15 | Neonatal Exposure to a Combination of N -Methyl-d-aspartate and γ-Aminobutyric Acid Type A Receptor Anesthetic Agents Potentiates Apoptotic Neurodegeneration and Persistent Behavioral Deficits | Anesthesiology | 2007 | 392 |
| 16 | Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice | Nature | 2012 | 364 |
| 17 | Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse | Genomics | 2006 | 354 |
| 18 | Olfactory Functions Are Mediated by Parallel and Hierarchical Processing | Neuron | 2000 | 351 |
| 19 | Infection Risks Among Patients With Multiple Sclerosis Treated With Fingolimod, Natalizumab, Rituximab, and Injectable Therapies | JAMA Neurology | 2020 | 342 |
| 20 | Trends in kinase drug discovery: targets, indications and inhibitor design | Nature Reviews Drug Discovery | 2021 | 340 |
| 21 | Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types | Nature Neuroscience | 2018 | 327 |
| 22 | Ghrelin increases anxiety-like behavior and memory retention in rats | Biochemical and Biophysical Research Communications | 2002 | 322 |
| 23 | From glutamate co-release to vesicular synergy: vesicular glutamate transporters | Nature Reviews Neuroscience | 2011 | 321 |
| 24 | The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain | Endocrinology | 2008 | 309 |
| 25 | OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons | Nature Neuroscience | 2012 | 306 |
| 26 | Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans | Diabetes | 2014 | 306 |
| 27 | Internet-Delivered Psychological Treatments for Mood and Anxiety Disorders: A Systematic Review of Their Efficacy, Safety, and Cost-Effectiveness | PLoS ONE | 2014 | 304 |
| 28 | Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin | Biochemical and Biophysical Research Communications | 2004 | 302 |
| 29 | Prenatal and perinatal risk factors for schizophrenia, affective psychosis, and reactive psychosis of early onset: case-control study Prenatal and perinatal risk factors for early onset schizophrenia, affective psychosis, and reactive psychosis | BMJ: British Medical Journal | 1999 | 297 |
| 30 | Corticolimbic anatomical characteristics predetermine risk for chronic pain | Brain | 2016 | 285 |
| 31 | Why Are Self-Report and Behavioral Measures Weakly Correlated? | Trends in Cognitive Sciences | 2020 | 276 |
| 32 | Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway | Biogerontology | 2013 | 274 |
| 33 | Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies | International Journal of Obesity | 2016 | 273 |
| 34 | Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: A systematic review | Psychoneuroendocrinology | 2014 | 265 |
| 35 | Consensus Meeting on Microdialysis in Neurointensive Care | Intensive Care Medicine | 2004 | 259 |
| 36 | Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport | Nature Neuroscience | 2009 | 258 |
| 37 | Intranasal Treatment of Central Nervous System Dysfunction in Humans | Pharmaceutical Research | 2013 | 253 |
| 38 | Acute Sleep Deprivation Enhances the Brain's Response to Hedonic Food Stimuli: An fMRI Study | Journal of Clinical Endocrinology and Metabolism | 2012 | 249 |
| 39 | Functions of the orexinergic/hypocretinergic system | American Journal of Physiology - Cell Physiology | 2002 | 247 |
| 40 | CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery | Journal of Neuroinflammation | 2012 | 243 |
| 41 | Association of Stress-Related Disorders With Subsequent Autoimmune Disease | JAMA - Journal of the American Medical Association | 2018 | 243 |
| 42 | Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives | FEBS Letters | 2003 | 237 |
| 43 | Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration | Behavioural Brain Research | 2004 | 231 |
| 44 | The GRAFS classification system of G-protein coupled receptors in comparative perspective | General and Comparative Endocrinology | 2005 | 230 |
| 45 | The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes | EBioMedicine | 2015 | 228 |
| 46 | Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review | Frontiers in Endocrinology | 2019 | 228 |
| 47 | Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy | Human Molecular Genetics | 2012 | 225 |
| 48 | Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment | Human Reproduction | 2008 | 221 |
| 49 | Prevalence of Headache in Swedish Schoolchildren, with a Focus on Tension-Type Headache | Cephalalgia | 2004 | 219 |
| 50 | Copy Number Variation in Intron 1 of SOX5 Causes the Pea-comb Phenotype in Chickens | PLoS Genetics | 2009 | 219 |
