| # | Title | Journal | Year | Citations |
|---|
| 1 | Evidence for an immune response in major depression: A review and hypothesis | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 1995 | 820 |
| 2 | Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression | Psychiatry Research | 1993 | 399 |
| 3 | International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci | Nature Communications | 2019 | 363 |
| 4 | Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression? | American Journal of Psychiatry | 1993 | 341 |
| 5 | A Nurse‐Led Interdisciplinary Intervention Program for Delirium in Elderly Hip‐Fracture Patients | Journal of the American Geriatrics Society | 2001 | 326 |
| 6 | Review and meta‐analysis of the phenomenology and clinical characteristics of mania in children and adolescents | Bipolar Disorders | 2005 | 296 |
| 7 | Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder | American Journal of Psychiatry | 1990 | 244 |
| 8 | Impact of Bipolar Disorder on a U.S. Community Sample | Journal of Clinical Psychiatry | 2003 | 224 |
| 9 | Seasonality in violent suicide but not in nonviolent suicide or homicide | American Journal of Psychiatry | 1993 | 214 |
| 10 | Α Review on the Acute Phase Response in Major Depression | Reviews in the Neurosciences | 1993 | 204 |
| 11 | The macrophage-T-lymphocyte theory of schizophrenia: Additional evidence | Medical Hypotheses | 1995 | 190 |
| 12 | Fluoxetine in the treatment of borderline and schizotypal personality disorders | American Journal of Psychiatry | 1991 | 163 |
| 13 | Long-Term, Open-Label Study of Risperidone in Children With Severe Disruptive Behaviors and Below-Average IQ | American Journal of Psychiatry | 2004 | 154 |
| 14 | Side Effects of Self-Administration of Intracavernous Papaverine and Phentolamine for the Treatment of Impotence | Journal of Urology | 1989 | 153 |
| 15 | Comparing the mental health needs of female and male incarcerated juvenile delinquents | | 1997 | 149 |
| 16 | Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression | Psychiatry Research | 1993 | 145 |
| 17 | Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia | Bipolar Disorders | 2009 | 133 |
| 18 | Synchronized annual rhythms in violent suicide rate, ambient temperature and the light‐dark span | Acta Psychiatrica Scandinavica | 1994 | 123 |
| 19 | Lower serum prolyl endopeptidase enzyme activity in major depression: Further evidence that peptidases play a role in the pathophysiology of depression | Biological Psychiatry | 1994 | 117 |
| 20 | Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder | Psychiatry Research - Neuroimaging | 2002 | 115 |
| 21 | Double-Blind, Placebo-Controlled Trial of Divalproex Monotherapy in the Treatment of Symptomatic Youth at High Risk for Developing Bipolar Disorder | Journal of Clinical Psychiatry | 2007 | 104 |
| 22 | Seasonal variation in peripheral blood leukocyte subsets and in serum interleukin-6, and soluble interleukin-2 and-6 receptor concentrations in normal volunteers | Experientia | 1994 | 93 |
| 23 | Early symptoms of mania and the role of parental risk | Bipolar Disorders | 2005 | 89 |
| 24 | Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates | Neuropathology and Applied Neurobiology | 2011 | 87 |
| 25 | Child murder by mothers: patterns and prevention | World Psychiatry | 2007 | 87 |
| 26 | Mechanisms of Clozapine†-Induced Agranulocytosis | Drug Safety | 1992 | 83 |
| 27 | Predictors of Response to Mood Stabilizers | Journal of Clinical Psychopharmacology | 1996 | 83 |
| 28 | Differential Impact of Lacunes and Microvascular Lesions on Poststroke Depression | Stroke | 2009 | 82 |
| 29 | An evaluation of basal hypothalamic-pituitary-thyroid axis function in depression: Results of a large-scaled and controlled study | Psychoneuroendocrinology | 1993 | 79 |
| 30 | Filicide-suicide: common factors in parents who kill their children and themselves | Journal of the American Academy of Psychiatry and the Law | 2005 | 79 |
| 31 | Immune disorders in depression: higher T helper/T suppressor‐cytotoxic cell ratio | Acta Psychiatrica Scandinavica | 1992 | 78 |
| 32 | Seasonality in severity of depression: relationships to suicide and homicide occurrence | Acta Psychiatrica Scandinavica | 1993 | 76 |
| 33 | Effects of ipsapirone on plasma cortisol and body temperature in major depression | Biological Psychiatry | 1995 | 75 |
| 34 | Paroxetine Pharmacokinetics in Depressed Children and Adolescents | Journal of the American Academy of Child and Adolescent Psychiatry | 1999 | 75 |
| 35 | Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects | Biological Psychiatry | 1994 | 74 |
| 36 | Olanzapine: A New Atypical Antipsychotic Drug | Neuropsychopharmacology | 1996 | 73 |
| 37 | Cognitive-behavioral therapy for bipolar disorders in adolescents: a pilot study | Bipolar Disorders | 2006 | 73 |
| 38 | Total serum protein and serum protein fractions in depression: relationships to depressive symptoms and glucocorticoid activity | Journal of Affective Disorders | 1995 | 71 |
| 39 | Relapse following clozapine withdrawal: effect of neuroleptic drugs and cyproheptadine | Psychopharmacology | 1996 | 71 |
| 40 | Relationships between increased haptoglobin plasma levels and activation of cell-mediated immunity in depression | Biological Psychiatry | 1993 | 68 |
| 41 | Autoimmunity in depression: increased antiphospholipid autoantibodies | Acta Psychiatrica Scandinavica | 1993 | 68 |
| 42 | Meta-analysis of brain size in bipolar disorder | Schizophrenia Research | 1999 | 68 |
| 43 | Maintenance Therapies in Bipolar Disorder: Focus on Randomized Controlled Trials | Australian and New Zealand Journal of Psychiatry | 2005 | 65 |
| 44 | Quetiapine and classical mood stabilizers in the long-term treatment of Bipolar Disorder: A 4-year follow-up naturalistic study | Journal of Affective Disorders | 2008 | 64 |
| 45 | Employing Parent, Teacher, and Youth Self-Report Checklists in Identifying Pediatric Bipolar Spectrum Disorders: An Examination of Diagnostic Accuracy and Clinical Utility | Journal of Child and Adolescent Psychopharmacology | 2003 | 61 |
| 46 | Transfer of the hematopoietic stem cell transplant patient to the intensive care unit: does it really matter? | Bone Marrow Transplantation | 2006 | 59 |
| 47 | Natural killer cell activity in major depression: Relation to circulating natural killer cells, cellular indices of the immune response, and depressive phenomenology | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 1994 | 58 |
| 48 | The impact of vascular burden on late-life depression | Brain Research Reviews | 2009 | 58 |
| 49 | Double-Blind, Randomized, Placebo-Controlled Long-Term Maintenance Study of Aripiprazole in Children With Bipolar Disorder | Journal of Clinical Psychiatry | 2012 | 58 |
| 50 | Twelve-month comparison of two treatments for erectile dysfunction: Self-injection versus external vacuum devices | Urology | 1992 | 56 |
