| # | Title | Journal | Year | Citations |
|---|
| 1 | A global genetic interaction network maps a wiring diagram of cellular function | Science | 2016 | 979 |
| 2 | Stem cell gene expression programs influence clinical outcome in human leukemia | Nature Medicine | 2011 | 894 |
| 3 | RIP3 mediates the embryonic lethality of caspase-8-deficient mice | Nature | 2011 | 881 |
| 4 | Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK | Nature Immunology | 2008 | 555 |
| 5 | Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations | Nature Genetics | 2015 | 451 |
| 6 | DNA-damage repair; the good, the bad, and the ugly | EMBO Journal | 2008 | 396 |
| 7 | Toll-like Receptors Induce a Phagocytic Gene Program through p38 | Journal of Experimental Medicine | 2004 | 377 |
| 8 | Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection | Journal of Experimental Medicine | 2004 | 375 |
| 9 | Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B | Molecular and Cellular Biology | 2002 | 313 |
| 10 | Advancing porphyrin's biomedical utility via supramolecular chemistry | Chemical Society Reviews | 2017 | 294 |
| 11 | DREAM Is a Critical Transcriptional Repressor for Pain Modulation | Cell | 2002 | 274 |
| 12 | Recurrent and functional regulatory mutations in breast cancer | Nature | 2017 | 269 |
| 13 | CD45: new jobs for an old acquaintance | Nature Immunology | 2001 | 264 |
| 14 | Genefu: an R/Bioconductor package for computation of gene expression-based signatures in breast cancer | Bioinformatics | 2016 | 255 |
| 15 | cFLIP regulation of lymphocyte activation and development | Nature Reviews Immunology | 2006 | 252 |
| 16 | Identifying Cancer Stem Cells in Solid Tumors: Case Not Proven | Cancer Research | 2006 | 244 |
| 17 | MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer | Cancer Research | 2011 | 242 |
| 18 | C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a | Nature | 2007 | 224 |
| 19 | Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles | Current Opinion in Chemical Biology | 2019 | 218 |
| 20 | Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringence | Journal of Biomedical Optics | 2008 | 204 |
| 21 | The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis | Immunity | 2016 | 191 |
| 22 | Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer | Urology | 2005 | 190 |
| 23 | Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling | Nature | 2013 | 190 |
| 24 | The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila | Oncogene | 2000 | 185 |
| 25 | STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry | Nature Communications | 2013 | 179 |
| 26 | Use of green fluorescent protein variants to monitor gene transfer and expression in mammalian cells | Nature Biotechnology | 1996 | 168 |
| 27 | Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR | Journal of Cell Biology | 2006 | 166 |
| 28 | Activation of TBK1 and IKKε Kinases by Vesicular Stomatitis Virus Infection and the Role of Viral Ribonucleoprotein in the Development of Interferon Antiviral Immunity | Journal of Virology | 2004 | 164 |
| 29 | Expression and Prognostic Significance of Metalloproteinases and Their Tissue Inhibitors in Patients With Small-Cell Lung Cancer | Journal of Clinical Oncology | 1999 | 162 |
| 30 | RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target | Gastroenterology | 2021 | 161 |
| 31 | Next-generation sequencing identifies rare variants associated with Noonan syndrome | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 158 |
| 32 | On the issue of transparency and reproducibility in nanomedicine | Nature Nanotechnology | 2019 | 149 |
| 33 | "Destemming" Cancer Stem Cells | Journal of the National Cancer Institute | 2007 | 140 |
| 34 | IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment | Cancer Research | 2015 | 140 |
| 35 | New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions | Journal of Gastroenterology and Hepatology (Australia) | 2002 | 139 |
| 36 | Nucleolar RNA polymerase II drives ribosome biogenesis | Nature | 2020 | 135 |
| 37 | T-cell signalling and autoimmunity: molecular mechanisms of disease | Nature Reviews Immunology | 2002 | 133 |
| 38 | IMPLICATION OF TOLL-LIKE RECEPTOR AND TUMOR NECROSIS FACTOR α SIGNALING IN SEPTIC SHOCK | Shock | 2005 | 130 |
| 39 | Negative Regulation of Mixed Lineage Kinase 3 by Protein Kinase B/AKT Leads to Cell Survival | Journal of Biological Chemistry | 2003 | 123 |
| 40 | The Role of Interleukin 1 Receptor-associated Kinase-4 (IRAK-4) Kinase Activity in IRAK-4-mediated Signaling | Journal of Biological Chemistry | 2004 | 121 |
| 41 | Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1 | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 120 |
| 42 | A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cells | Gene Therapy | 1997 | 118 |
| 43 | Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer | Journal of Experimental Medicine | 2010 | 112 |
| 44 | BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors | Journal of Proteomics | 2015 | 112 |
| 45 | A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy | Photochemical and Photobiological Sciences | 2016 | 109 |
| 46 | A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation | Science | 2006 | 105 |
| 47 | Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis | Future Oncology | 2008 | 103 |
| 48 | Photodynamic Therapy for Urological Malignancies: Past to Current Approaches | Journal of Urology | 2006 | 101 |
| 49 | Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca 2+ homeostasis | EMBO Molecular Medicine | 2013 | 101 |
| 50 | Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 100 |
