| # | Title | Journal | Year | Citations |
|---|
| 1 | Functional Disability 5 Years after Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2011 | 2,228 |
| 2 | One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2003 | 2,073 |
| 3 | Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma | Gastroenterology | 2016 | 1,365 |
| 4 | Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,261 |
| 5 | Risk Factors for Central and Obstructive Sleep Apnea in 450 Men And Women with Congestive Heart Failure | American Journal of Respiratory and Critical Care Medicine | 1999 | 1,040 |
| 6 | Stem cell gene expression programs influence clinical outcome in human leukemia | Nature Medicine | 2011 | 894 |
| 7 | Risk Factors for Extubation Failure in Patients Following a Successful Spontaneous Breathing Trial | Chest | 2006 | 885 |
| 8 | Peginterferon Alfa-2a in Patients with Chronic Hepatitis C and Cirrhosis | New England Journal of Medicine | 2000 | 832 |
| 9 | Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group | Kidney International | 2017 | 748 |
| 10 | Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene | Nature Medicine | 1996 | 710 |
| 11 | Association of SGLT2 Inhibitors With Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes | JAMA Cardiology | 2021 | 625 |
| 12 | Drug treatments for covid-19: living systematic review and network meta-analysis | BMJ, The | 2020 | 592 |
| 13 | Adverse Effects of Androgen Deprivation Therapy and Strategies to Mitigate Them | European Urology | 2015 | 561 |
| 14 | Phase I Study of Individualized Stereotactic Body Radiotherapy for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma | Journal of Clinical Oncology | 2008 | 541 |
| 15 | Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus | Nature Genetics | 2008 | 534 |
| 16 | Glucagon-Like Peptides | Diabetes | 1998 | 507 |
| 17 | The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals Regarding the Clinical Staging of Small Cell Lung Cancer in the Forthcoming (Seventh) Edition of the Tumor, Node, Metastasis Classification for Lung Cancer | Journal of Thoracic Oncology | 2007 | 503 |
| 18 | Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors | BMJ: British Medical Journal | 2005 | 489 |
| 19 | Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease | Brain | 2000 | 488 |
| 20 | Molecular Mimicry and Autoimmunity | New England Journal of Medicine | 1999 | 455 |
| 21 | Glucagon-Like Peptides: Regulators of Cell Proliferation, Differentiation, and Apoptosis | Molecular Endocrinology | 2003 | 444 |
| 22 | Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells | Nature Immunology | 2007 | 436 |
| 23 | The IASLC Lung Cancer Staging Project: Proposals Regarding the Relevance of TNM in the Pathologic Staging of Small Cell Lung Cancer in the Forthcoming (Seventh) Edition of the TNM Classification for Lung Cancer | Journal of Thoracic Oncology | 2009 | 435 |
| 24 | Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2015 | 408 |
| 25 | Two-Year Outcomes, Health Care Use, and Costs of Survivors of Acute Respiratory Distress Syndrome | American Journal of Respiratory and Critical Care Medicine | 2006 | 405 |
| 26 | Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury | Bone Marrow Transplantation | 2007 | 400 |
| 27 | Cardiac Sarcoidosis | Journal of the American College of Cardiology | 2016 | 400 |
| 28 | Clinical features of 78 adults with 22q11 deletion syndrome | American Journal of Medical Genetics, Part A | 2005 | 381 |
| 29 | A contemporary approach to validity arguments: a practical guide to Kane's framework | Medical Education | 2015 | 371 |
| 30 | Hepatocellular Carcinoma: Epidemiology, Risk Factors, and Screening | Seminars in Liver Disease | 2005 | 368 |
| 31 | Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial | JAMA - Journal of the American Medical Association | 2018 | 367 |
| 32 | IgA Nephropathy | Clinical Journal of the American Society of Nephrology: CJASN | 2017 | 358 |
| 33 | Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model | Nature Medicine | 2006 | 342 |
| 34 | Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 342 |
| 35 | Regression of left ventricular hypertrophy after conversion to nocturnal hemodialysis | Kidney International | 2002 | 329 |
| 36 | Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery | Journal of Thoracic and Cardiovascular Surgery | 2005 | 329 |
| 37 | Imported Malaria: Prospective Analysis of Problems in Diagnosis and Management | Clinical Infectious Diseases | 1998 | 325 |
| 38 | CPG 7909, an Immunostimulatory TLR9 Agonist Oligodeoxynucleotide, as Adjuvant to Engerix-B� HBV Vaccine in Healthy Adults: A Double-Blind Phase I/II Study | Journal of Clinical Immunology | 2004 | 306 |
| 39 | Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: Incidence and prevalence of hepatocellular carcinoma in a North American urban population | Hepatology | 1995 | 305 |
| 40 | Second Primary Malignancy Risk After Radioactive Iodine Treatment for Thyroid Cancer: A Systematic Review and Meta-analysis | Thyroid | 2009 | 296 |
| 41 | Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity | Intensive Care Medicine | 2015 | 286 |
| 42 | Abnormal intrinsic brain functional network dynamics in Parkinson’s disease | Brain | 2017 | 281 |
| 43 | Mechanisms of Hepatic Very Low Density Lipoprotein Overproduction in Insulin Resistance | Journal of Biological Chemistry | 2000 | 278 |
| 44 | Clinical utility and prospective of TMS–EEG | Clinical Neurophysiology | 2019 | 276 |
| 45 | Platelet interactions with titanium: modulation of platelet activity by surface topography | Biomaterials | 2001 | 274 |
| 46 | Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia | Nature Genetics | 2015 | 274 |
| 47 | Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease | JAMA Neurology | 2015 | 272 |
| 48 | The RECOVER Program: Disability Risk Groups and 1-Year Outcome after 7 or More Days of Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2016 | 272 |
| 49 | Risk and Predictors for Pregnancy-Related Complications in Women With Heart Disease | Circulation | 1997 | 272 |
| 50 | Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer | Lancet Oncology, The | 2003 | 268 |
