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Top Articles

#TitleJournalYearCitations
1De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysisNature Protocols20137,054
2Antibiotic resistance and its cost: is it possible to reverse resistance?Nature Reviews Microbiology20101,855
3High interstitial fluid pressure — an obstacle in cancer therapyNature Reviews Cancer20041,814
4The genomic basis of adaptive evolution in threespine sticklebacksNature20121,600
5Microbiological effects of sublethal levels of antibioticsNature Reviews Microbiology20141,255
6Selection of Resistant Bacteria at Very Low Antibiotic ConcentrationsPLoS Pathogens20111,248
7Analyses of pig genomes provide insight into porcine demography and evolutionNature20121,190
8Whole-genome resequencing reveals loci under selection during chicken domesticationNature2010985
9The genomic signature of dog domestication reveals adaptation to a starch-rich dietNature2013805
10Evolution of Darwin’s finches and their beaks revealed by genome sequencingNature2015766
11Definitions and guidelines for research on antibiotic persistenceNature Reviews Microbiology2019748
12Worldwide Phylogeography of Wild Boar Reveals Multiple Centers of Pig DomesticationScience2005729
13Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horseNature2013717
14Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activityProceedings of the National Academy of Sciences of the United States of America2013701
15Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic HorseScience2009680
16A Mutation in PRKAG3 Associated with Excess Glycogen Content in Pig Skeletal MuscleScience2000647
17Regulated Diversity of Heparan SulfateJournal of Biological Chemistry1998597
18Strong signatures of selection in the domestic pig genomeProceedings of the National Academy of Sciences of the United States of America2012548
19MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structuresNature Communications2015534
20Domestic-animal genomics: deciphering the genetics of complex traitsNature Reviews Genetics2004516
21Myrosinase: gene family evolution and herbivore defense in BrassicaceaePlant Molecular Biology2000491
22Mechanisms and consequences of bacterial resistance to antimicrobial peptidesDrug Resistance Updates2016491
23The genomic landscape underlying phenotypic integrity in the face of gene flow in crowsScience2014490
24Efficient mapping of mendelian traits in dogs through genome-wide associationNature Genetics2007474
25Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy MetalsMBio2014451
26Consensus guidelines for the use and interpretation of angiogenesis assaysAngiogenesis2018429
27Interactions between heparan sulfate and proteins: the concept of specificityJournal of Cell Biology2006421
28Rethinking dog domestication by integrating genetics, archeology, and biogeographyProceedings of the National Academy of Sciences of the United States of America2012412
29Identification of the Yellow Skin Gene Reveals a Hybrid Origin of the Domestic ChickenPLoS Genetics2008399
30The biological cost of mutational antibiotic resistance: any practical conclusions?Current Opinion in Microbiology2006397
31Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphsNature2012377
32The Putative Tumor Suppressors EXT1 and EXT2 Are Glycosyltransferases Required for the Biosynthesis of Heparan SulfateJournal of Biological Chemistry1998374
33Mutations in DMRT3 affect locomotion in horses and spinal circuit function in miceNature2012364
34TGF-β SignalingBiomolecules2020347
35Rabbit genome analysis reveals a polygenic basis for phenotypic change during domesticationScience2014343
36Structural genomic changes underlie alternative reproductive strategies in the ruff (Philomachus pugnax)Nature Genetics2016340
37Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection MappingPLoS Genetics2011339
38Rapid hybrid speciation in Darwin’s finchesScience2018327
39Structure and biological interactions of heparin and heparan sulfateAdvances in Carbohydrate Chemistry and Biochemistry2001325
40Persistence of antibiotic resistance in bacterial populationsFEMS Microbiology Reviews2011325
41Ohno's dilemma: Evolution of new genes under continuous selectionProceedings of the National Academy of Sciences of the United States of America2007313
42Predicting antibiotic resistanceNature Reviews Microbiology2007305
43Evolution of high-level resistance during low-level antibiotic exposureNature Communications2018300
44Bacterial gene amplification: implications for the evolution of antibiotic resistanceNature Reviews Microbiology2009299
45Antibiotic susceptibility testing in less than 30 min using direct single-cell imagingProceedings of the National Academy of Sciences of the United States of America2017296
46From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans – Call for a One Health approachOne Health2020287
47Patterns of East Asian pig domestication, migration, and turnover revealed by modern and ancient DNAProceedings of the National Academy of Sciences of the United States of America2010279
48Epistasis and the release of genetic variation during long-term selectionNature Genetics2006278
49Deep mitochondrial origin outside the sampled alphaproteobacteriaNature2018278
50A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis melliferaNature Genetics2014273