| # | Title | Journal | Year | Citations |
|---|
| 1 | Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB | Applied and Environmental Microbiology | 2006 | 9,859 |
| 2 | Accurate prediction of protein structures and interactions using a three-track neural network | Science | 2021 | 2,843 |
| 3 | Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates | Molecular Cell | 2013 | 2,734 |
| 4 | High Gamma Power Is Phase-Locked to Theta Oscillations in Human Neocortex | Science | 2006 | 2,269 |
| 5 | The repertoire of mutational signatures in human cancer | Nature | 2020 | 2,104 |
| 6 | A protocol for generating a high-quality genome-scale metabolic reconstruction | Nature Protocols | 2010 | 1,568 |
| 7 | A comparative encyclopedia of DNA elements in the mouse genome | Nature | 2014 | 1,444 |
| 8 | Inertial microfluidics | Lab on A Chip | 2009 | 1,349 |
| 9 | A comprehensive classification system for lipids | Journal of Lipid Research | 2005 | 1,348 |
| 10 | Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells | Nature | 2013 | 1,316 |
| 11 | Update of the LIPID MAPS comprehensive classification system for lipids | Journal of Lipid Research | 2009 | 1,300 |
| 12 | A travel guide to Cytoscape plugins | Nature Methods | 2012 | 1,289 |
| 13 | Nanoparticle biointerfacing by platelet membrane cloaking | Nature | 2015 | 1,270 |
| 14 | Recent advances in 3D printing of biomaterials | Journal of Biological Engineering | 2015 | 1,266 |
| 15 | The complete sequence of a human genome | Science | 2022 | 1,222 |
| 16 | Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages | Frontiers in Immunology | 2019 | 1,202 |
| 17 | The 2017 terahertz science and technology roadmap | Journal Physics D: Applied Physics | 2017 | 1,160 |
| 18 | Assessing computational tools for the discovery of transcription factor binding sites | Nature Biotechnology | 2005 | 1,121 |
| 19 | A fast, robust and tunable synthetic gene oscillator | Nature | 2008 | 1,079 |
| 20 | Synthetic protein scaffolds provide modular control over metabolic flux | Nature Biotechnology | 2009 | 1,071 |
| 21 | COBRApy: COnstraints-Based Reconstruction and Analysis for Python | BMC Systems Biology | 2013 | 973 |
| 22 | KBase: The United States Department of Energy Systems Biology Knowledgebase | Nature Biotechnology | 2018 | 955 |
| 23 | Genome-scale models of microbial cells: evaluating the consequences of constraints | Nature Reviews Microbiology | 2004 | 935 |
| 24 | Dry-Contact and Noncontact Biopotential Electrodes: Methodological Review | IEEE Reviews in Biomedical Engineering | 2010 | 931 |
| 25 | A community-driven global reconstruction of human metabolism | Nature Biotechnology | 2013 | 920 |
| 26 | A comprehensive genome‐scale reconstruction of Escherichia coli metabolism—2011 | Molecular Systems Biology | 2011 | 917 |
| 27 | A synchronized quorum of genetic clocks | Nature | 2010 | 916 |
| 28 | Control, exploitation and tolerance of intracellular noise | Nature | 2002 | 909 |
| 29 | Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue | Journal of Biomechanics | 2004 | 883 |
| 30 | Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication | Cell | 2008 | 881 |
| 31 | An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR) | Genome Biology | 2003 | 880 |
| 32 | In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data | Nature Biotechnology | 2001 | 877 |
| 33 | Designing multifunctional quantum dots for bioimaging, detection, and drug delivery | Chemical Society Reviews | 2010 | 866 |
| 34 | SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 | Cell | 2020 | 860 |
| 35 | The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 833 |
| 36 | Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0 | Nature Protocols | 2019 | 833 |
| 37 | The Global Phosphorylation Landscape of SARS-CoV-2 Infection | Cell | 2020 | 825 |
| 38 | Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain | Science | 2016 | 822 |
| 39 | Fractal design concepts for stretchable electronics | Nature Communications | 2014 | 821 |
| 40 | Interplay of matrix stiffness and protein tethering in stem cell differentiation | Nature Materials | 2014 | 812 |
| 41 | Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth | Nature | 2002 | 797 |
| 42 | Reconstruction of biochemical networks in microorganisms | Nature Reviews Microbiology | 2009 | 797 |
| 43 | Materials as stem cell regulators | Nature Materials | 2014 | 794 |
| 44 | Mechanics, malignancy, and metastasis: The force journey of a tumor cell | Cancer and Metastasis Reviews | 2009 | 791 |
| 45 | ClassyFire: automated chemical classification with a comprehensive, computable taxonomy | Journal of Cheminformatics | 2016 | 779 |
| 46 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 47 | Conformable amplified lead zirconate titanate sensors with enhanced piezoelectric response for cutaneous pressure monitoring | Nature Communications | 2014 | 757 |
| 48 | Skin microbiota: a source of disease or defence? | British Journal of Dermatology | 2008 | 746 |
| 49 | BiGG Models: A platform for integrating, standardizing and sharing genome-scale models | Nucleic Acids Research | 2016 | 746 |
| 50 | Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis | Science Translational Medicine | 2017 | 744 |
