| # | Title | Journal | Year | Citations |
|---|
| 1 | Slipped-strand mispairing: a major mechanism for DNA sequence evolution. | Molecular Biology and Evolution | 1987 | 1,885 |
| 2 | Isogenic strain construction and gene mapping in Candida albicans. | Genetics | 1993 | 1,617 |
| 3 | Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia | Cell | 1993 | 1,295 |
| 4 | Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen | Nature | 1992 | 1,178 |
| 5 | Regulation of Intestinal -Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense | Science | 1999 | 1,041 |
| 6 | Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice | Science | 1993 | 853 |
| 7 | Dominance and Crypticity of T Cell Antigenic Determinants | Annual Review of Immunology | 1993 | 819 |
| 8 | International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels | Pharmacological Reviews | 2005 | 785 |
| 9 | Complex N-Glycan Number and Degree of Branching Cooperate to Regulate Cell Proliferation and Differentiation | Cell | 2007 | 777 |
| 10 | Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor | Cell | 1990 | 672 |
| 11 | The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) | Journal of Bacteriology | 1992 | 655 |
| 12 | Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein | Nature | 1992 | 594 |
| 13 | Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 581 |
| 14 | The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF | Nature | 1999 | 569 |
| 15 | Steel locus defines new multipotent growth factor | Cell | 1990 | 522 |
| 16 | NF- B-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 505 |
| 17 | The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca 2+ Pathway To Antagonize Wnt/β-Catenin Signaling | Molecular and Cellular Biology | 2003 | 503 |
| 18 | Molecular basis of the little mouse phenotype and Implications for cell type-specific growth | Nature | 1993 | 477 |
| 19 | Decoding the Epigenetic Language of Neuronal Plasticity | Neuron | 2008 | 468 |
| 20 | Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor | Cell | 1991 | 457 |
| 21 | Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor | Nature | 1989 | 454 |
| 22 | Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases | Science | 1996 | 425 |
| 23 | Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron | Cell Host and Microbe | 2013 | 413 |
| 24 | BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. | Molecular and Cellular Biology | 1991 | 408 |
| 25 | Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter. | Genes and Development | 1992 | 399 |
| 26 | Protein 3CD is the major poliovirus proteinase responsible for cleavage of the p1 capsid precursor | Virology | 1988 | 374 |
| 27 | Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer | Oncogene | 2000 | 372 |
| 28 | Diversity of LEF/TCF action in development and disease | Oncogene | 2006 | 372 |
| 29 | BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner | Cell | 1991 | 362 |
| 30 | Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage | Journal of Bacteriology | 1996 | 359 |
| 31 | Up-regulation of the IKCa1 Potassium Channel during T-cell Activation | Journal of Biological Chemistry | 2000 | 357 |
| 32 | Leukemia and the disruption of normal hematopoiesis | Cell | 1991 | 353 |
| 33 | Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer | EMBO Journal | 2014 | 348 |
| 34 | The SR protein family | Genome Biology | 2009 | 345 |
| 35 | Prothrombin mRNA is expressed by cells of the nervous system | Neuron | 1991 | 337 |
| 36 | A repair system for 8-Oxo-7,8-dihydrodeoxyguanine | Biochemistry | 1992 | 316 |
| 37 | Thrombin modulates and reverses neuroblastoma neurite outgrowth. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 315 |
| 38 | Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein | Science | 1990 | 311 |
| 39 | Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression | Virology | 1992 | 311 |
| 40 | Proliferation of mutators in A cell population | Journal of Bacteriology | 1997 | 310 |
| 41 | SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage | PLoS Pathogens | 2011 | 308 |
| 42 | Effect of glycosylation on antibody function: implications for genetic engineering | Trends in Biotechnology | 1997 | 303 |
| 43 | Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain | Immunity | 1996 | 302 |
| 44 | Evolution of SR protein and hnRNP splicing regulatory factors | Wiley Interdisciplinary Reviews RNA | 2012 | 301 |
| 45 | Impaired expansion of mouse B cell progenitors lacking Btk | Immunity | 1995 | 300 |
| 46 | Whole genome-based phylogenetic analysis of free-living microorganisms | Nucleic Acids Research | 1999 | 293 |
| 47 | Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein | Molecular and Cellular Biology | 2000 | 292 |
| 48 | Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53–Mediated Mouse Mammary Tumors | Cancer Research | 2008 | 292 |
| 49 | Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities | Journal of Neuroscience | 1997 | 289 |
| 50 | Spatial regulation of the exocyst complex by Rho1 GTPase | Nature Cell Biology | 2001 | 288 |
