| # | Title | Journal | Year | Citations |
|---|
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| 2 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,653 |
| 3 | The TNF and TNF Receptor Superfamilies | Cell | 2001 | 3,271 |
| 4 | Bilirubin is an antioxidant of possible physiological importance | Science | 1987 | 3,202 |
| 5 | Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage | Science | 1984 | 2,131 |
| 6 | Signal transduction by lymphocyte antigen receptors | Cell | 1994 | 2,108 |
| 7 | Hepatitis B Virus Infection — Natural History and Clinical Consequences | New England Journal of Medicine | 2004 | 2,075 |
| 8 | Molecular themes in oncogenesis | Cell | 1991 | 1,607 |
| 9 | Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour | Nature | 1983 | 1,295 |
| 10 | Duration of Nuclear NF-kappa B Action Regulated by Reversible Acetylation | Science | 2001 | 1,153 |
| 11 | CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs | Nature | 2006 | 1,014 |
| 12 | Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population | Nature | 2006 | 982 |
| 13 | Reduced Paneth cell -defensins in ileal Crohn's disease | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 954 |
| 14 | Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis | Nature Reviews Microbiology | 2011 | 932 |
| 15 | Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall | Science | 1999 | 923 |
| 16 | An alternative pathway for yeast telomere maintenance rescues est1− senescence | Cell | 1993 | 914 |
| 17 | Multiple Sigma Subunits and the Partitioning of Bacterial Transcription Space | Annual Review of Microbiology | 2003 | 864 |
| 18 | Wnt genes | Cell | 1992 | 856 |
| 19 | Germinal-Center Organization and Cellular Dynamics | Immunity | 2007 | 838 |
| 20 | Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate | Science | 2007 | 826 |
| 21 | Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution | Science | 2009 | 821 |
| 22 | A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response | Cell | 2016 | 819 |
| 23 | Reversible Tumorigenesis by MYC in Hematopoietic Lineages | Molecular Cell | 1999 | 798 |
| 24 | Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses | Science | 2007 | 777 |
| 25 | Structure and variability of human chromosome ends. | Molecular and Cellular Biology | 1990 | 773 |
| 26 | CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS | Annual Review of Immunology | 2005 | 772 |
| 27 | Candida albicans Biofilms and Human Disease | Annual Review of Microbiology | 2015 | 768 |
| 28 | RNA virus error catastrophe: Direct molecular test by using ribavirin | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 766 |
| 29 | The Molecular Genetics of Cellular Oncogenes | Annual Review of Genetics | 1984 | 747 |
| 30 | Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor | Cell | 1984 | 746 |
| 31 | Multiplexed droplet single-cell RNA-sequencing using natural genetic variation | Nature Biotechnology | 2018 | 745 |
| 32 | Identification and Characterization of an Exotoxin from Staphylococcus aureus Associated with Toxic-Shock Syndrome | Journal of Infectious Diseases | 1981 | 735 |
| 33 | Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas | Nature | 1982 | 725 |
| 34 | Coordinated Induction by IL15 of a TCR-Independent NKG2D Signaling Pathway Converts CTL into Lymphokine-Activated Killer Cells in Celiac Disease | Immunity | 2004 | 723 |
| 35 | Quasispecies Theory and the Behavior of RNA Viruses | PLoS Pathogens | 2010 | 717 |
| 36 | Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice | Cell | 1988 | 708 |
| 37 | Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs | Annual Review of Immunology | 2012 | 708 |
| 38 | Imaging of Germinal Center Selection Events During Affinity Maturation | Science | 2007 | 701 |
| 39 | Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway | Cell | 2012 | 681 |
| 40 | Form and function of retroviral proviruses | Science | 1982 | 667 |
| 41 | Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs | PLoS Genetics | 2013 | 655 |
| 42 | Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice | Immunity | 2000 | 647 |
| 43 | Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs | Cell | 1990 | 646 |
| 44 | Reprogramming human T cell function and specificity with non-viral genome targeting | Nature | 2018 | 630 |
| 45 | Type VII secretion — mycobacteria show the way | Nature Reviews Microbiology | 2007 | 628 |
| 46 | Phenotypic Landscape of a Bacterial Cell | Cell | 2011 | 623 |
| 47 | Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy | Cell | 2021 | 613 |
| 48 | Heat shock factor and the heat shock response | Cell | 1991 | 608 |
| 49 | A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans | Cell | 2012 | 607 |
| 50 | Failure of B-cell differentiation in mice lacking the transcription factor EBF | Nature | 1995 | 603 |
