| # | Title | Journal | Year | Citations |
|---|
| 1 | The rapid evolution of reproductive proteins | Nature Reviews Genetics | 2002 | 1,177 |
| 2 | Widespread and Persistent Populations of a Major New Marine Actinomycete Taxon in Ocean Sediments | Applied and Environmental Microbiology | 2002 | 500 |
| 3 | Pressure effects on in vivo microbial processes | BBA - Proteins and Proteomics | 2002 | 402 |
| 4 | Retrospective analysis of natural products provides insights for future discovery trends | Proceedings of the National Academy of Sciences of the United States of America | 2017 | 382 |
| 5 | Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra | Nature Biotechnology | 2021 | 317 |
| 6 | Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae | International Journal of Systematic and Evolutionary Microbiology | 2005 | 295 |
| 7 | Phylogenetic Diversity of Gram-Positive Bacteria Cultured from Marine Sediments | Applied and Environmental Microbiology | 2007 | 288 |
| 8 | The Genomisotopic Approach: A Systematic Method to Isolate Products of Orphan Biosynthetic Gene Clusters | Chemistry and Biology | 2007 | 285 |
| 9 | Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora | Applied and Environmental Microbiology | 2007 | 281 |
| 10 | Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse | Chemical Reviews | 2017 | 281 |
| 11 | Antimicrobial Peptides from Marine Invertebrates | Antimicrobial Agents and Chemotherapy | 2004 | 270 |
| 12 | Marine actinomycete diversity and natural product discovery | Antonie Van Leeuwenhoek | 2005 | 269 |
| 13 | The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp. | Organic Letters | 2008 | 269 |
| 14 | Induced Production of Emericellamides A and B from the Marine-Derived FungusEmericellasp. in Competing Co-culture | Journal of Natural Products | 2007 | 265 |
| 15 | Discovery and development of the anticancer agent salinosporamide A (NPI-0052) | Bioorganic and Medicinal Chemistry | 2009 | 259 |
| 16 | Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 241 |
| 17 | Monounsaturated but Not Polyunsaturated Fatty Acids Are Required for Growth of the Deep-Sea Bacterium Photobacterium profundum SS9 at High Pressure and Low Temperature | Applied and Environmental Microbiology | 1999 | 221 |
| 18 | Prokaryotic lifestyles in deep sea habitats | Extremophiles | 2008 | 201 |
| 19 | Compositional differences in particle‐associated and free‐living microbial assemblages from an extreme deep‐ocean environment | Environmental Microbiology Reports | 2011 | 189 |
| 20 | Vertical Transmission of Diverse Microbes in the Tropical Sponge Corticium sp. | Applied and Environmental Microbiology | 2007 | 186 |
| 21 | Libertellenones A–D: Induction of cytotoxic diterpenoid biosynthesis by marine microbial competition | Bioorganic and Medicinal Chemistry | 2005 | 170 |
| 22 | Biosynthesis and Structures of Cyclomarins and Cyclomarazines, Prenylated Cyclic Peptides of Marine Actinobacterial Origin | Journal of the American Chemical Society | 2008 | 168 |
| 23 | Exploring the Phylogenetic Utility of ITS Sequences for Animals: A Test Case for Abalone (Haliotis) | Journal of Molecular Evolution | 2002 | 167 |
| 24 | The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery | Natural Product Reports | 2015 | 155 |
| 25 | Emerging concepts on microbial processes in the bathypelagic ocean – ecology, biogeochemistry, and genomics | Deep-Sea Research Part II: Topical Studies in Oceanography | 2010 | 153 |
| 26 | Rapid evolution of fertilization selectivity and lysin cDNA sequences in teguline gastropods | Molecular Biology and Evolution | 1999 | 151 |
| 27 | Structure and regulation of the omega-3 polyunsaturated fatty acid synthase genes from the deep-sea bacterium Photobacterium profundum strain SS9 The GenBank accession numbers for the sequences reported in this paper are AF409100 and AF467805. | Microbiology (United Kingdom) | 2002 | 151 |
| 28 | Molecular Networking and Pattern-Based Genome Mining Improves Discovery of Biosynthetic Gene Clusters and their Products from Salinispora Species | Chemistry and Biology | 2015 | 150 |
| 29 | Enzymatic Cascade Reactions in Biosynthesis | Angewandte Chemie - International Edition | 2019 | 150 |
| 30 | Chemical ecology of marine microbial defense | Journal of Chemical Ecology | 2002 | 148 |
| 31 | Bile salt–induced intermolecular disulfide bond formation activates Vibrio cholerae virulence | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 147 |
| 32 | The Fucose Sulfate Polymer of Egg Jelly Binds to Sperm REJ and Is the Inducer of the Sea Urchin Sperm Acrosome Reaction | Developmental Biology | 1997 | 145 |
| 33 | Multiple defensive roles for triterpene glycosides from two Caribbean sponges | Oecologia | 2002 | 144 |
| 34 | Sporolides A and B: Structurally Unprecedented Halogenated Macrolides from the Marine ActinomyceteSalinisporatropica | Organic Letters | 2005 | 143 |
| 35 | Enzymatic Manganese(II) Oxidation by a Marine α-Proteobacterium | Applied and Environmental Microbiology | 2001 | 142 |
| 36 | Diving Behavior of Emperor Penguins Nurturing Chicks at Coulman Island, Antarctica | Condor | 1995 | 141 |
| 37 | Gene transcript changes in individual rainbow trout livers following an inflammatory stimulus | Fish and Shellfish Immunology | 2007 | 134 |
| 38 | Isolation and Structure Assignments of Rostratins A−D, Cytotoxic Disulfides Produced by the Marine-Derived Fungus Exserohilum rostratum | Journal of Natural Products | 2004 | 133 |
| 39 | NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products | Journal of Natural Products | 2021 | 131 |
| 40 | The Unique 16S rRNA Genes of Piezophiles Reflect both Phylogeny and Adaptation | Applied and Environmental Microbiology | 2007 | 126 |
| 41 | Cholix Toxin, a Novel ADP-ribosylating Factor from Vibrio cholerae | Journal of Biological Chemistry | 2008 | 126 |
| 42 | Solute accumulation in the deep-sea bacterium Photobacterium profundum | Extremophiles | 2002 | 125 |
| 43 | Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders | Immunopharmacology and Immunotoxicology | 2010 | 125 |
| 44 | Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom | Science | 2018 | 124 |
| 45 | Environmental Adaptation: Genomic Analysis of the Piezotolerant and Psychrotolerant Deep-Sea Iron Reducing Bacterium Shewanella piezotolerans WP3 | PLoS ONE | 2008 | 123 |
| 46 | Culture-Dependent and Culture-Independent Diversity within the Obligate Marine Actinomycete Genus Salinispora | Applied and Environmental Microbiology | 2005 | 121 |
| 47 | Identification of a regulatory protein required for pressure‐responsive gene expression in the deep‐sea bacterium Photobacterium species strain SS9 | Molecular Microbiology | 1998 | 116 |
| 48 | Submersible- and lander-observed community patterns in the Mariana and New Britain trenches: Influence of productivity and depth on epibenthic and scavenging communities | Deep-Sea Research Part I: Oceanographic Research Papers | 2015 | 115 |
| 49 | A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products | Journal of the American Chemical Society | 2020 | 114 |
| 50 | Piperazimycins: Cytotoxic Hexadepsipeptides from a Marine-Derived Bacterium of the Genus Streptomyces | Journal of Organic Chemistry | 2007 | 113 |
