Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission | Cancer Research | 2009 | 871 |
Effect of obesity on the pharmacokinetics of drugs in humans | Clinical Pharmacokinetics | 2010 | 482 |
Activation of central melanocortin pathways by fenfluramine | Science | 2002 | 408 |
Prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy | Circulation | 2008 | 368 |
Critical role of mast cells in inflammatory diseases and the effect of acute stress | Journal of Neuroimmunology | 2004 | 336 |
Diazepam disposition determinants | Clinical Pharmacology and Therapeutics | 1980 | 319 |
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants | Drug Metabolism and Disposition | 2000 | 265 |
The "normal" endocrine cell of the gut: changing concepts and new evidences | Annals of the New York Academy of Sciences | 2004 | 227 |
IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 225 |
Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells | British Journal of Pharmacology | 2005 | 221 |
The critical role of mast cells in allergy and inflammation | Annals of the New York Academy of Sciences | 2006 | 212 |
In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5 | Drug Metabolism and Disposition | 2003 | 210 |
Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation | Anesthesiology | 1990 | 200 |
Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir | Journal of Clinical Pharmacology | 1998 | 193 |
Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress | Journal of Pharmacology and Experimental Therapeutics | 2002 | 191 |
A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 158 |
Zolpidem for insomnia | Expert Opinion on Pharmacotherapy | 2012 | 154 |
Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography | Journal of the American College of Cardiology | 2013 | 141 |
Estradiol augments while tamoxifen inhibits rat mast cell secretion | International Archives of Allergy and Immunology | 1992 | 136 |
Stress-Induced Bladder Mast Cell Activation: Implications for Interstitial Cystitis | Journal of Urology | 1997 | 127 |
Hydroxyzine therapy for interstitial cystitis | Urology | 1997 | 125 |
Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice | Clinical Pharmacology and Therapeutics | 2003 | 125 |
Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity | Psychopharmacology | 1987 | 111 |
Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans | PLoS ONE | 2012 | 111 |
Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 104 |