| # | Title | Journal | Year | Citations |
|---|
| 1 | The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers | Nature | 2012 | 1,506 |
| 2 | Molecular therapies and precision medicine for hepatocellular carcinoma | Nature Reviews Clinical Oncology | 2018 | 1,308 |
| 3 | Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma | Science | 2010 | 1,090 |
| 4 | iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL | Blood | 2018 | 1,069 |
| 5 | Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer | Nature Genetics | 2012 | 1,049 |
| 6 | Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma | Nature Medicine | 2019 | 932 |
| 7 | A shared neural ensemble links distinct contextual memories encoded close in time | Nature | 2016 | 756 |
| 8 | The “cancer immunogram” | Science | 2016 | 655 |
| 9 | Peroxisome proliferator-activated receptor gamma and cancers | Clinical Cancer Research | 2003 | 648 |
| 10 | Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia | Nature | 2012 | 641 |
| 11 | Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers | British Journal of Cancer | 2006 | 555 |
| 12 | Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients | Lancet, The | 1996 | 529 |
| 13 | Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor | Nature | 1986 | 514 |
| 14 | Rational Combinations of Trastuzumab With Chemotherapeutic Drugs Used in the Treatment of Breast Cancer | Journal of the National Cancer Institute | 2004 | 488 |
| 15 | Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients? | American Society of Clinical Oncology Educational Book / ASCO American Society of Clinical Oncology Meeting | 2019 | 459 |
| 16 | Intermittent Target Inhibition With Dasatinib 100 mg Once Daily Preserves Efficacy and Improves Tolerability in Imatinib-Resistant and -Intolerant Chronic-Phase Chronic Myeloid Leukemia | Journal of Clinical Oncology | 2008 | 458 |
| 17 | The molecular mechanisms that control thrombopoiesis | Journal of Clinical Investigation | 2005 | 453 |
| 18 | Mesenchymal stem cells for the treatment of neurodegenerative disease | Regenerative Medicine | 2010 | 452 |
| 19 | Anti-VEGF Antibody Treatment of Glioblastoma Prolongs Survival But Results in Increased Vascular Cooption | Neoplasia | 2000 | 451 |
| 20 | Chronic Lymphocytic Leukemia B Cells Express Functional CXCR4 Chemokine Receptors That Mediate Spontaneous Migration Beneath Bone Marrow Stromal Cells | Blood | 1999 | 443 |
| 21 | Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer | Cancer Cell | 2008 | 443 |
| 22 | Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer | Cell | 2020 | 436 |
| 23 | mRNA structure determines specificity of a polyQ-driven phase separation | Science | 2018 | 421 |
| 24 | Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma | American Journal of Pathology | 2009 | 409 |
| 25 | Promoter CpG Methylation Contributes to ES Cell Gene Regulation in Parallel with Oct4/Nanog, PcG Complex, and Histone H3 K4/K27 Trimethylation | Cell Stem Cell | 2008 | 395 |
| 26 | Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010 | Blood | 2005 | 390 |
| 27 | Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53 | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 364 |
| 28 | Cell cycle regulation in hematopoietic stem cells | Journal of Cell Biology | 2011 | 362 |
| 29 | Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers | Gynecologic Oncology | 2008 | 359 |
| 30 | Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities | Cell Stem Cell | 2015 | 358 |
| 31 | International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia | Leukemia | 2007 | 351 |
| 32 | Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib | Leukemia | 2008 | 341 |
| 33 | Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 329 |
| 34 | An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition | Nature Cell Biology | 2014 | 325 |
| 35 | Phase I Study of Intraventricular Administration of Rituximab in Patients With Recurrent CNS and Intraocular Lymphoma | Journal of Clinical Oncology | 2007 | 308 |
| 36 | Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia | Nature Genetics | 2010 | 308 |
| 37 | Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 296 |
| 38 | Anti–Cytotoxic T-Lymphocyte Antigen-4 Antibody: The First in an Emerging Class of Immunomodulatory Antibodies for Cancer Treatment | Journal of Clinical Oncology | 2008 | 294 |
| 39 | Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 285 |
| 40 | Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC | Nature Medicine | 2007 | 283 |
| 41 | BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma | Cancer Discovery | 2019 | 278 |
| 42 | Sources of Absorption and Scattering Contrast for Near-Infrared Optical Mammography | Academic Radiology | 2001 | 276 |
| 43 | Results of Two Open-Label, Multicenter Phase II Studies of Docetaxel, Platinum Salts, and Trastuzumab in HER2-Positive Advanced Breast Cancer | Journal of the National Cancer Institute | 2004 | 271 |
| 44 | Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity | Blood | 2016 | 259 |
| 45 | Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells | Oncogene | 2003 | 255 |
| 46 | The incidence of venous thromboembolism among patients with primary lung cancer | Journal of Thrombosis and Haemostasis | 2008 | 247 |
| 47 | Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders | Science | 1986 | 242 |
| 48 | Tissue Determinants of Human NK Cell Development, Function, and Residence | Cell | 2020 | 242 |
| 49 | Potentiating Endogenous Antitumor Immunity to Prostate Cancer through Combination Immunotherapy with CTLA4 Blockade and GM-CSF | Cancer Research | 2009 | 238 |
| 50 | ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia | Blood | 2005 | 225 |
