| # | Title | Journal | Year | Citations |
|---|
| 1 | Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease | New England Journal of Medicine | 2013 | 2,001 |
| 2 | Ulcerative colitis | Lancet, The | 2012 | 1,497 |
| 3 | Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease | Hepatology | 2018 | 1,474 |
| 4 | ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus | American Journal of Gastroenterology | 2016 | 1,275 |
| 5 | The gut–liver axis and the intersection with the microbiome | Nature Reviews Gastroenterology and Hepatology | 2018 | 905 |
| 6 | Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation | Nature Medicine | 2016 | 844 |
| 7 | The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver | Journal of Biological Chemistry | 1998 | 837 |
| 8 | Nonalcoholic Steatohepatitis | JAMA - Journal of the American Medical Association | 2020 | 784 |
| 9 | Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate-to-Severe Ulcerative Colitis | Gastroenterology | 2014 | 753 |
| 10 | Role of Cytokines in the Pathogenesis of Inflammatory Bowel Disease | Annual Review of Medicine | 2000 | 637 |
| 11 | Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events | JAMA - Journal of the American Medical Association | 2016 | 614 |
| 12 | Subcutaneous Golimumab Maintains Clinical Response in Patients With Moderate-to-Severe Ulcerative Colitis | Gastroenterology | 2014 | 605 |
| 13 | Intravenous N-Acetylcysteine Improves Transplant-Free Survival in Early Stage Non-Acetaminophen Acute Liver Failure | Gastroenterology | 2009 | 573 |
| 14 | Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways | Cell | 2017 | 568 |
| 15 | The clinical utility of endoscopic ultrasound–guided fine-needle aspiration in the diagnosisand staging of pancreatic carcinoma | Gastrointestinal Endoscopy | 1997 | 566 |
| 16 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B 1 1The Adefovir Dipivoxil International 461 Study Group includes the following: N. Afdhal (Beth Israel Deaconess Medical Center, Boston, MA); P. Angus (Austin and Repatriation Medical Centre, Melbourne, Australia); Y. Benhamou (Hopital La Pitie Salpetriere, Paris, France); M. Bourliere (Hopital Saint Joseph, Marseille, France); P. Buggisch (Universitaetsklinikum Eppendorf, Department of Medic | Gastroenterology | 2004 | 554 |
| 17 | The gut microbiome: Relationships with disease and opportunities for therapy | Journal of Experimental Medicine | 2019 | 547 |
| 18 | A gp130–Src–YAP module links inflammation to epithelial regeneration | Nature | 2015 | 528 |
| 19 | Efficacy of Biological Therapies in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis | American Journal of Gastroenterology | 2011 | 523 |
| 20 | Development of the Crohnʼs disease digestive damage score, the Lémann score | Inflammatory Bowel Diseases | 2011 | 496 |
| 21 | Protective association of aspirin/NSAIDs and esophageal cancer: A systematic review and meta-analysis | Gastroenterology | 2003 | 480 |
| 22 | American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease | Gastroenterology | 2017 | 440 |
| 23 | Placental Transfer of Anti–Tumor Necrosis Factor Agents in Pregnant Patients With Inflammatory Bowel Disease | Clinical Gastroenterology and Hepatology | 2013 | 420 |
| 24 | A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches | Gastroenterology | 2012 | 414 |
| 25 | Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial | Lancet, The | 2018 | 374 |
| 26 | Sinus Microbiome Diversity Depletion and Corynebacterium tuberculostearicum Enrichment Mediates Rhinosinusitis | Science Translational Medicine | 2012 | 372 |
| 27 | A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: An Update | Clinical Gastroenterology and Hepatology | 2006 | 371 |
| 28 | Liver transplantation for hepatocellular carcinoma: Comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria | Liver Transplantation | 2002 | 367 |
| 29 | Liver transplantation for hepatocellular carcinoma: Analysis of survival according to the intention-to-treat principle and dropout from the waiting list | Liver Transplantation | 2002 | 355 |
| 30 | AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis | Gastroenterology | 2020 | 355 |
| 31 | Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection | Blood | 2013 | 347 |
| 32 | Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition | Cancer Research | 2009 | 340 |
| 33 | The bile acid TGR5 membrane receptor: From basic research to clinical application | Digestive and Liver Disease | 2014 | 340 |
| 34 | Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome | Cell Host and Microbe | 2015 | 327 |
| 35 | Selection of primers for optimal taxonomic classification of environmental 16S rRNA gene sequences | ISME Journal | 2012 | 326 |
| 36 | Endoscopic injection sclerosis in bleeding gastric varices | Gastrointestinal Endoscopy | 1986 | 322 |
| 37 | Ischemic hepatitis: clinical presentation and pathogenesis | American Journal of Medicine | 2000 | 316 |
| 38 | Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review | Clinical Gastroenterology and Hepatology | 2018 | 299 |
| 39 | Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines | Nature Immunology | 2001 | 294 |
| 40 | Suspected Nonalcoholic Fatty Liver Disease and Mortality Risk in a Population-Based Cohort Study | American Journal of Gastroenterology | 2008 | 294 |
| 41 | Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study | Gastroenterology | 2015 | 294 |
| 42 | Intestinal permeability in patients with Crohn's disease and their healthy relatives | Gastroenterology | 1989 | 291 |
| 43 | Correlation between liver histology and novel magnetic resonance imaging in adult patients with non‐alcoholic fatty liver disease – MRI accurately quantifies hepatic steatosis in NAFLD | Alimentary Pharmacology and Therapeutics | 2012 | 285 |
| 44 | The stomach in health and disease | Gut | 2015 | 283 |
| 45 | Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials | Gut | 2017 | 274 |
| 46 | Airway Microbiome Dynamics in Exacerbations of Chronic Obstructive Pulmonary Disease | Journal of Clinical Microbiology | 2014 | 272 |
| 47 | Development and validation of a histological index for UC | Gut | 2017 | 264 |
| 48 | Liver transplantation for “very early” intrahepatic cholangiocarcinoma: International retrospective study supporting a prospective assessment | Hepatology | 2016 | 262 |
| 49 | Epidemiology of Hepatitis C Virus (HCV) Infection | International Journal of Medical Sciences | 2006 | 259 |
| 50 | Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants | Clinical Gastroenterology and Hepatology | 2019 | 254 |
