| # | Title | Journal | Year | Citations |
|---|
| 1 | Parkinson's disease | Lancet, The | 2015 | 4,079 |
| 2 | A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD | Neuron | 2011 | 3,833 |
| 3 | Pharmacological Treatment of Parkinson Disease | JAMA - Journal of the American Medical Association | 2014 | 1,097 |
| 4 | Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity | Nature Genetics | 2012 | 848 |
| 5 | Peginterferon Alfa-2a in Patients with Chronic Hepatitis C and Cirrhosis | New England Journal of Medicine | 2000 | 832 |
| 6 | 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 759 |
| 7 | Epidemiology of Human Pulmonary Infection with Nontuberculous Mycobacteria | Clinics in Chest Medicine | 2015 | 665 |
| 8 | Gastrointestinal dysfunction in Parkinson's disease | Lancet Neurology, The | 2015 | 653 |
| 9 | Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review | Movement Disorders | 2019 | 619 |
| 10 | Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1 | Nature Genetics | 2013 | 589 |
| 11 | Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus | Nature Genetics | 2008 | 534 |
| 12 | Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue | Journal of Hepatology | 2011 | 470 |
| 13 | Molecular Mimicry and Autoimmunity | New England Journal of Medicine | 1999 | 455 |
| 14 | Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2015 | 408 |
| 15 | Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans | Science | 1978 | 398 |
| 16 | Definition and classification of hyperkinetic movements in childhood | Movement Disorders | 2010 | 374 |
| 17 | Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies | Journal of the American Academy of Dermatology | 2019 | 362 |
| 18 | CPG 7909, an Immunostimulatory TLR9 Agonist Oligodeoxynucleotide, as Adjuvant to Engerix-B� HBV Vaccine in Healthy Adults: A Double-Blind Phase I/II Study | Journal of Clinical Immunology | 2004 | 306 |
| 19 | Cerebral Infarction After Subarachnoid Hemorrhage Contributes to Poor Outcome by Vasospasm-Dependent and -Independent Effects | Stroke | 2011 | 302 |
| 20 | Abnormal intrinsic brain functional network dynamics in Parkinson’s disease | Brain | 2017 | 281 |
| 21 | Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia | Nature Genetics | 2015 | 274 |
| 22 | Long-Term Follow-up of Unilateral Pallidotomy in Advanced Parkinson's Disease | New England Journal of Medicine | 2000 | 263 |
| 23 | The Insertion and Management of External Ventricular Drains: An Evidence-Based Consensus Statement | Neurocritical Care | 2016 | 247 |
| 24 | Pallidal neuronal activity: Implications for models of dystonia | Annals of Neurology | 2003 | 246 |
| 25 | A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy | Nature Genetics | 2015 | 245 |
| 26 | Left Ventricular Wall Motion Abnormalities in Subarachnoid Hemorrhage: An Echocardiographic Study | Journal of the American College of Cardiology | 1988 | 220 |
| 27 | Sclerosing cholangitis: A focus on secondary causes | Hepatology | 2006 | 213 |
| 28 | Management of Antiviral Resistance in Patients with Chronic Hepatitis B | Antiviral Therapy | 2004 | 200 |
| 29 | Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: A meta-analysis of individual patient data | Hepatology | 2004 | 198 |
| 30 | Disease‐modifying strategies for Parkinson's disease | Movement Disorders | 2015 | 188 |
| 31 | The effect of telemedicine in critically ill patients: systematic review and meta-analysis | Critical Care | 2012 | 186 |
| 32 | Opioids Compared With Placebo or Other Treatments for Chronic Low Back Pain | Spine | 2014 | 184 |
| 33 | Depression and Anxiety in Psoriatic Disease: Prevalence and Associated Factors | Journal of Rheumatology | 2014 | 184 |
| 34 | Do patients with psoriatic arthritis who present early fare better than those presenting later in the disease? | Annals of the Rheumatic Diseases | 2011 | 183 |
| 35 | Onychomycosis in children: Prevalence and treatment strategies | Journal of the American Academy of Dermatology | 1997 | 178 |
| 36 | Predictors of Impaired Daytime Sleep and Wakefulness in Patients With Parkinson Disease Treated With Older (Ergot) vs Newer (Nonergot) Dopamine Agonists | Archives of Neurology | 2004 | 174 |
| 37 | Assessment of Safety and Efficacy of Safinamide as a Levodopa Adjunct in Patients With Parkinson Disease and Motor Fluctuations | JAMA Neurology | 2017 | 171 |
| 38 | Analysis of the PINK1 Gene in a Large Cohort of Cases With Parkinson Disease | Archives of Neurology | 2004 | 162 |
| 39 | Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci | Nature Communications | 2015 | 156 |
| 40 | Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial | Lancet, The | 2022 | 145 |
| 41 | Prospective Randomized Trial of 10% Povidone‐Iodine versus 0.5% Tincture of Chlorhexidine as Cutaneous Antisepsis for Prevention of Central Venous Catheter Infection | Clinical Infectious Diseases | 2000 | 140 |
| 42 | Premotor Parkinson's disease: Concepts and definitions | Movement Disorders | 2012 | 140 |
| 43 | Long-term follow-up of antimitochondrial antibody-positive autoimmune hepatitis | Hepatology | 2008 | 137 |
| 44 | Cognitive Impairment and Rehabilitation Strategies After Traumatic Brain Injury | Indian Journal of Psychological Medicine | 2016 | 129 |
| 45 | Primary biliary cirrhosis | Orphanet Journal of Rare Diseases | 2008 | 128 |
| 46 | Cutaneous adverse effects associated with terbinafine therapy: 10 case reports and a review of the literature | British Journal of Dermatology | 1998 | 122 |
| 47 | Lymphoma risk in systemic lupus: effects of disease activity versus treatment | Annals of the Rheumatic Diseases | 2014 | 115 |
| 48 | Prevalence of sclerosing cholangitis in adults with autoimmune hepatitis: Evaluating the role of routine magnetic resonance imaging | Hepatology | 2008 | 114 |
| 49 | Treatment guidelines in psoriatic arthritis | Rheumatology | 2020 | 111 |
| 50 | Complete differentiation of adipocyte precursors | Cell and Tissue Research | 1978 | 109 |
