| # | Title | Journal | Year | Citations |
|---|
| 1 | ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain | Cell | 1992 | 1,029 |
| 2 | NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis | Science Translational Medicine | 2013 | 1,016 |
| 3 | Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis | Annals of the Rheumatic Diseases | 2009 | 772 |
| 4 | Treatment of Ankylosing Spondylitis by Inhibition of Tumor Necrosis Factor α | New England Journal of Medicine | 2002 | 745 |
| 5 | Potential Biases in Machine Learning Algorithms Using Electronic Health Record Data | JAMA Internal Medicine | 2018 | 693 |
| 6 | CD28 Costimulation: From Mechanism to Therapy | Immunity | 2016 | 607 |
| 7 | Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry | Annals of the Rheumatic Diseases | 2021 | 496 |
| 8 | Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force | Annals of the Rheumatic Diseases | 2018 | 484 |
| 9 | Does This Adult Patient Have Septic Arthritis? | JAMA - Journal of the American Medical Association | 2007 | 481 |
| 10 | Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway | Nature | 1990 | 469 |
| 11 | Comparison of low-dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A Controlled Clinical Trial | Arthritis and Rheumatism | 1985 | 464 |
| 12 | Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer | Cell | 2020 | 436 |
| 13 | Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial | Annals of the Rheumatic Diseases | 2009 | 424 |
| 14 | Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force | Annals of the Rheumatic Diseases | 2014 | 397 |
| 15 | Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial | Annals of the Rheumatic Diseases | 2011 | 394 |
| 16 | The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 388 |
| 17 | Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: A critical review | Journal of Autoimmunity | 2015 | 370 |
| 18 | Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells | Cell | 2009 | 362 |
| 19 | Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 352 |
| 20 | MicroRNA-29 Regulates T-Box Transcription Factors and Interferon-γ Production in Helper T Cells | Immunity | 2011 | 325 |
| 21 | Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 324 |
| 22 | Genetic susceptibility to systemic lupus erythematosus in the genomic era | Nature Reviews Rheumatology | 2010 | 319 |
| 23 | A role for sex chromosome complement in the female bias in autoimmune disease | Journal of Experimental Medicine | 2008 | 317 |
| 24 | Apoptotic Cells with Oxidation-specific Epitopes Are Immunogenic and Proinflammatory | Journal of Experimental Medicine | 2004 | 310 |
| 25 | Methotrexate and histologic hepatic abnormalities: A meta-analysis | American Journal of Medicine | 1991 | 306 |
| 26 | Human lymphocyte subpopulations. Effect of corticosteroids. | Journal of Clinical Investigation | 1974 | 298 |
| 27 | Endogenous antigen tunes the responsiveness of naive B cells but not T cells | Nature | 2012 | 284 |
| 28 | Randomized, Double-Blind, Placebo Controlled Trial of Low-Dose Pulse Methotrexate in Psoriatic Arthritis | Arthritis and Rheumatism | 1984 | 279 |
| 29 | Analysis of improvement in individual rheumatoid arthritis patients treated with disease-modifying antirheumatic drugs, based on the findings in patients treated with placebo | Arthritis and Rheumatism | 1990 | 278 |
| 30 | The occupational burden of chronic obstructive pulmonary disease | European Respiratory Journal | 2003 | 277 |
| 31 | High disease activity is associated with an increased risk of infection in patients with rheumatoid arthritis | Annals of the Rheumatic Diseases | 2011 | 269 |
| 32 | Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist | Nature Medicine | 2020 | 262 |
| 33 | Gene Expression (Collagenase, Tissue Inhibitor of Metalloproteinases, Complement, and HLA–DR) in Rheumatoid Arthritis and Osteoarthritis Synovium. Quantitative Analysis and Effect of Intraarticular Corticosteroids | Arthritis and Rheumatism | 1991 | 247 |
| 34 | The Pathogenesis of Systemic Sclerosis | Annual Review of Pathology: Mechanisms of Disease | 2011 | 247 |
| 35 | Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee | Arthritis and Rheumatism | 1993 | 239 |
| 36 | Regulation of Homeostatic Chemokine Expression and Cell Trafficking During Immune Responses | Science | 2007 | 234 |
| 37 | Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort | Annals of the Rheumatic Diseases | 2007 | 225 |
| 38 | Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug | Blood | 2010 | 224 |
| 39 | Intravenous Injection of a D1 Protein of the Smith Proteins Postpones Murine Lupus and Induces Type 1 Regulatory T Cells | Journal of Immunology | 2004 | 220 |
| 40 | Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 206 |
| 41 | Accelerated atherosclerosis in patients with SLE—mechanisms and management | Nature Reviews Rheumatology | 2012 | 201 |
| 42 | Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: A longitudinal study | Arthritis and Rheumatism | 1999 | 198 |
| 43 | Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial | Lancet, The | 2018 | 198 |
| 44 | Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation | Molecular Psychiatry | 2017 | 191 |
| 45 | The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression | Nature Immunology | 2013 | 183 |
| 46 | Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis | American Journal of Human Genetics | 2014 | 182 |
| 47 | Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis | BMJ: British Medical Journal | 2002 | 180 |
| 48 | The Immunopathogenesis of Rheumatoid Arthritis | Annual Review of Pathology: Mechanisms of Disease | 2009 | 180 |
| 49 | Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus | Journal of Immunology | 2009 | 177 |
| 50 | The work impact of asthma and rhinitis | Journal of Clinical Epidemiology | 2001 | 172 |
