# | Title | Journal | Year | Citations |
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1 | An all atom force field for simulations of proteins and nucleic acids | Journal of Computational Chemistry | 1986 | 3,292 |
2 | An approach to computing electrostatic charges for molecules | Journal of Computational Chemistry | 1984 | 3,071 |
3 | Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America | Clinical Infectious Diseases | 2016 | 2,060 |
4 | A geometric approach to macromolecule-ligand interactions | Journal of Molecular Biology | 1982 | 2,043 |
5 | Pharmaceutical Applications of Solid Dispersion Systems | Journal of Pharmaceutical Sciences | 1971 | 1,452 |
6 | Polyamidoamine cascade polymers mediate efficient transfection of cells in culture | Bioconjugate Chemistry | 1993 | 1,158 |
7 | A combinedab initio quantum mechanical and molecular mechanical method for carrying out simulations on complex molecular systems: Applications to the CH3Cl + Cl? exchange reaction and gas phase protonation of polyethers | Journal of Computational Chemistry | 1986 | 1,072 |
8 | DOCK 4.0: search strategies for automated molecular docking of flexible molecule databases | Journal of Computer-Aided Molecular Design | 2001 | 1,022 |
9 | Structure-Based Strategies for Drug Design and Discovery | Science | 1992 | 961 |
10 | Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes | Journal of Biological Chemistry | 2003 | 950 |
11 | Automated docking with grid-based energy evaluation | Journal of Computational Chemistry | 1992 | 900 |
12 | Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality | Chemistry and Biology | 2014 | 865 |
13 | Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society | Epilepsy Currents | 2016 | 859 |
14 | In Vitro Gene Delivery by Degraded Polyamidoamine Dendrimers | Bioconjugate Chemistry | 1996 | 818 |
15 | Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’ | Nature | 2011 | 781 |
16 | AMP-activated protein kinase phosphorylation of endothelial NO synthase | FEBS Letters | 1999 | 729 |
17 | Changes in plasma protein binding have little clinical relevance | Clinical Pharmacology and Therapeutics | 2002 | 680 |
18 | Clearance concepts in pharmacokinetics | Journal of Pharmacokinetics and Pharmacodynamics | 1973 | 674 |
19 | Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance | Journal of Pharmacokinetics and Pharmacodynamics | 1977 | 673 |
20 | Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 654 |
21 | Mechanism of oligonucleotide release from cationic liposomes. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 607 |
22 | Potential Role of Pharmacogenomics in Reducing Adverse Drug Reactions | JAMA - Journal of the American Medical Association | 2001 | 598 |
23 | Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery | Human Gene Therapy | 1996 | 572 |
24 | Critical evaluation of search algorithms for automated molecular docking and database screening | Journal of Computational Chemistry | 1997 | 543 |
25 | Electrostatic recognition between superoxide and copper, zinc superoxide dismutase | Nature | 1983 | 541 |
26 | Barriers to diabetes management: Patient and provider factors | Diabetes Research and Clinical Practice | 2011 | 491 |
27 | Cancer nanomedicines: So many papers and so few drugs! | Advanced Drug Delivery Reviews | 2013 | 472 |
28 | The Gut as a Barrier to Drug Absorption | Clinical Pharmacokinetics | 2001 | 468 |
29 | The Akt kinase signals directly to endothelial nitric oxide synthase | Current Biology | 1999 | 445 |
30 | Building population pharmacokineticpharmacodynamic models. I. Models for covariate effects | Journal of Pharmacokinetics and Pharmacodynamics | 1992 | 442 |
31 | New Method for Calculating the Intrinsic Absorption Rate of Drugs | Journal of Pharmaceutical Sciences | 1968 | 428 |
32 | Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids | Circulation Research | 2000 | 428 |
33 | Origin of myofibroblasts in the fibrotic liver in mice | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 414 |
34 | The importance of modeling interoccasion variability in population pharmacokinetic analyses | Journal of Pharmacokinetics and Pharmacodynamics | 1993 | 409 |
35 | Molecular docking to ensembles of protein structures 1 1Edited by B. Honig | Journal of Molecular Biology | 1997 | 391 |
36 | Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment | Nature | 1990 | 378 |
37 | Shortcomings in Pharmacokinetic Analysis by Conceiving the Body to Exhibit Properties of a Single Compartment | Journal of Pharmaceutical Sciences | 1968 | 368 |
38 | Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check | Journal of Pharmacokinetics and Pharmacodynamics | 2001 | 357 |
39 | Man versus Beast: Pharmacokinetic Scaling in Mammals | Journal of Pharmaceutical Sciences | 1986 | 344 |
40 | The Cell Biology of Antigen Processing and Presentation | Annual Review of Immunology | 1991 | 339 |
41 | A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform 1 1Edited by M. Yaniv | Journal of Molecular Biology | 1997 | 333 |
42 | Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes | Pharmaceutical Research | 1992 | 313 |
43 | Executive Summary: Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America | Clinical Infectious Diseases | 2016 | 311 |
44 | 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition | Science | 2016 | 305 |
45 | Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA | Biochemistry | 1990 | 303 |
46 | Living with clathrin: its role in intracellular membrane traffic | Science | 1988 | 298 |
47 | Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor | Molecular Microbiology | 2000 | 292 |
48 | Effect of Loop Sequence and Size on DNA Aptamer Stability† | Biochemistry | 2000 | 276 |
49 | Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus | Clinical Pharmacokinetics | 2002 | 272 |
50 | Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 271 |