| # | Title | Journal | Year | Citations |
|---|
| 1 | Astrocytes: biology and pathology | Acta Neuropathologica | 2010 | 3,978 |
| 2 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 3 | Fat and Beyond: The Diverse Biology of PPARγ | Annual Review of Biochemistry | 2008 | 1,757 |
| 4 | Nanomechanical analysis of cells from cancer patients | Nature Nanotechnology | 2007 | 1,650 |
| 5 | Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer | Cell | 2015 | 1,485 |
| 6 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,191 |
| 7 | Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores | American Journal of Human Genetics | 2015 | 1,098 |
| 8 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors | Nature Medicine | 2003 | 1,088 |
| 9 | Mammalian defensins in the antimicrobial immune response | Nature Immunology | 2005 | 1,070 |
| 10 | PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation | Nature Medicine | 2001 | 1,014 |
| 11 | Global histone modification patterns predict risk of prostate cancer recurrence | Nature | 2005 | 991 |
| 12 | Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis | Cancer Research | 2006 | 953 |
| 13 | Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis | Science | 2012 | 886 |
| 14 | Multiplexed ion beam imaging of human breast tumors | Nature Medicine | 2014 | 881 |
| 15 | Regulatory interactions between muscle and the immune system during muscle regeneration | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2010 | 859 |
| 16 | Synthetic LXR ligand inhibits the development of atherosclerosis in mice | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 844 |
| 17 | Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders | JAMA - Journal of the American Medical Association | 2014 | 842 |
| 18 | American College of Medical Genetics standards and guidelines for interpretation and reporting of postnatal constitutional copy number variants | Genetics in Medicine | 2011 | 794 |
| 19 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 20 | ApoE Promotes the Proteolytic Degradation of Aβ | Neuron | 2008 | 779 |
| 21 | A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2 | Tissue Engineering - Part B: Reviews | 2016 | 741 |
| 22 | Integration of metabolism and inflammation by lipid-activated nuclear receptors | Nature | 2008 | 712 |
| 23 | The minimum information about a proteomics experiment (MIAPE) | Nature Biotechnology | 2007 | 694 |
| 24 | Hydrodynamic stretching of single cells for large population mechanical phenotyping | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 669 |
| 25 | LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor | Science | 2009 | 661 |
| 26 | Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors | Journal of Biological Chemistry | 2002 | 637 |
| 27 | Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR | Nature Reviews Molecular Cell Biology | 2012 | 616 |
| 28 | Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP | Cell | 2005 | 579 |
| 29 | LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response | Cell | 2008 | 579 |
| 30 | Role of the Autonomic Nervous System in Atrial Fibrillation | Circulation Research | 2014 | 578 |
| 31 | Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers | Angewandte Chemie - International Edition | 2011 | 576 |
| 32 | Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases | American Journal of Human Genetics | 2014 | 569 |
| 33 | Colocalization of GWAS and eQTL Signals Detects Target Genes | American Journal of Human Genetics | 2016 | 569 |
| 34 | Sex differences and hormonal effects on gut microbiota composition in mice | Gut Microbes | 2016 | 564 |
| 35 | The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology | American Journal of Transplantation | 2017 | 551 |
| 36 | LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response | Cell | 2004 | 498 |
| 37 | Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions | Nature Genetics | 2010 | 479 |
| 38 | Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice | Cell Metabolism | 2013 | 464 |
| 39 | UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells | EMBO Journal | 2011 | 437 |
| 40 | Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism | Molecular Cell | 2003 | 436 |
| 41 | Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway | Journal of Immunology | 2004 | 429 |
| 42 | Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis | Nature Genetics | 2009 | 428 |
| 43 | Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells | Molecular Cell | 2010 | 426 |
| 44 | Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 424 |
| 45 | Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron | Cell Host and Microbe | 2013 | 413 |
| 46 | Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal | Cell Stem Cell | 2012 | 397 |
| 47 | Mitochondrial double-stranded RNA triggers antiviral signalling in humans | Nature | 2018 | 397 |
| 48 | Virtual histological staining of unlabelled tissue-autofluorescence images via deep learning | Nature Biomedical Engineering | 2019 | 397 |
| 49 | Liver X receptors in lipid signalling and membrane homeostasis | Nature Reviews Endocrinology | 2018 | 387 |
| 50 | Colorectal carcinoma: Pathologic aspects | Journal of Gastrointestinal Oncology | 2012 | 385 |
