| # | Title | Journal | Year | Citations |
|---|
|
| 1 | An automated method for finding molecular complexes in large protein interaction networks | BMC Bioinformatics | 2003 | 4,969 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 3 | Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry | Nature | 2002 | 3,463 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 5 | The Genetic Landscape of a Cell | Science | 2010 | 1,962 |
| 6 | Enhanced electrocatalytic CO2 reduction via field-induced reagent concentration | Nature | 2016 | 1,557 |
| 7 | Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles | Molecular Cell | 2015 | 1,510 |
| 8 | Reactome: a database of reactions, pathways and biological processes | Nucleic Acids Research | 2011 | 1,430 |
| 9 | High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities | Cell | 2015 | 1,407 |
| 10 | A Bayesian Networks Approach for Predicting Protein-Protein Interactions from Genomic Data | Science | 2003 | 1,189 |
| 11 | BCL-2 family proteins: changing partners in the dance towards death | Cell Death and Differentiation | 2018 | 1,132 |
| 12 | What Should We Make with CO2 and How Can We Make It? | Joule | 2018 | 1,091 |
| 13 | A global genetic interaction network maps a wiring diagram of cellular function | Science | 2016 | 1,037 |
| 14 | Intrinsic dynamics of an enzyme underlies catalysis | Nature | 2005 | 1,034 |
| 15 | Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 1,017 |
| 16 | Proximal events in Wnt signal transduction | Nature Reviews Molecular Cell Biology | 2009 | 991 |
| 17 | BIND: the Biomolecular Interaction Network Database | Nucleic Acids Research | 2003 | 975 |
| 18 | Mitochondria, oxygen free radicals, disease and ageing | Trends in Biochemical Sciences | 2000 | 950 |
| 19 | Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms | Chemical Reviews | 2014 | 945 |
| 20 | Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization | Science | 2008 | 935 |
| 21 | BIND--The Biomolecular Interaction Network Database | Nucleic Acids Research | 2001 | 857 |
| 22 | Preparation of Suspensions of Washed Platelets from Humans | British Journal of Haematology | 1972 | 845 |
| 23 | Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons | Neuron | 2001 | 836 |
| 24 | Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 | Cell Death and Differentiation | 2015 | 828 |
| 25 | Catalyst electro-redeposition controls morphology and oxidation state for selective carbon dioxide reduction | Nature Catalysis | 2018 | 812 |
| 26 | Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map | Nature | 2007 | 811 |
| 27 | Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines | Nature | 1985 | 806 |
| 28 | Complex N-Glycan Number and Degree of Branching Cooperate to Regulate Cell Proliferation and Differentiation | Cell | 2007 | 795 |
| 29 | Resveratrol: A molecule whose time has come? And gone? | Clinical Biochemistry | 1997 | 759 |
| 30 | Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients | Science Immunology | 2020 | 745 |
| 31 | Navigating the Chaperone Network: An Integrative Map of Physical and Genetic Interactions Mediated by the Hsp90 Chaperone | Cell | 2005 | 743 |
| 32 | Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death | EMBO Journal | 2009 | 713 |
| 33 | Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system | Nature | 2013 | 711 |
| 34 | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser | Nature | 2015 | 699 |
| 35 | Mechanisms of regulation of the Na+/H+ exchanger | Journal of Membrane Biology | 1986 | 681 |
| 36 | Strategies for discovering novel cancer biomarkers through utilization of emerging technologies | Nature Clinical Practice Oncology | 2008 | 680 |
| 37 | Detergent binding explains anomalous SDS-PAGE migration of membrane proteins | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 676 |
| 38 | Sensitivity of secondary structure propensities to sequence differences between α- and γ-synuclein: Implications for fibrillation | Protein Science | 2006 | 665 |
| 39 | Structural basis of calcium-induced E-cadherin rigidification and dimerization | Nature | 1996 | 664 |
| 40 | Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination | EMBO Journal | 1997 | 663 |
| 41 | Fructose, insulin resistance, and metabolic dyslipidemia | Nutrition and Metabolism | 2005 | 655 |
| 42 | Non-coding RNA: what is functional and what is junk? | Frontiers in Genetics | 2015 | 652 |
| 43 | High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies | Molecular Cell | 2018 | 627 |
| 44 | Crystal structure of metarhodopsin II | Nature | 2011 | 626 |
| 45 | The genomes of four tapeworm species reveal adaptations to parasitism | Nature | 2013 | 625 |
| 46 | Phagosome maturation: aging gracefully | Biochemical Journal | 2002 | 616 |
| 47 | Gli Proteins in Development and Disease | Annual Review of Cell and Developmental Biology | 2011 | 614 |
| 48 | 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark | Nature | 2013 | 606 |
| 49 | A Co-Evolution Theory of the Genetic Code | Proceedings of the National Academy of Sciences of the United States of America | 1975 | 602 |
| 50 | Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways | Nature Biotechnology | 2004 | 591 |
