| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | The Human Transcription Factors | Cell | 2018 | 2,048 |
| 4 | The Genetic Landscape of a Cell | Science | 2010 | 1,937 |
| 5 | Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation | PLoS ONE | 2010 | 1,883 |
| 6 | Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity | Cell | 2014 | 1,515 |
| 7 | High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities | Cell | 2015 | 1,339 |
| 8 | A compendium of RNA-binding motifs for decoding gene regulation | Nature | 2013 | 1,281 |
| 9 | DNA-Binding Specificities of Human Transcription Factors | Cell | 2013 | 1,085 |
| 10 | The DNA-encoded nucleosome organization of a eukaryotic genome | Nature | 2009 | 1,063 |
| 11 | The sequence and de novo assembly of the giant panda genome | Nature | 2010 | 1,058 |
| 12 | Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia | Nature | 2010 | 980 |
| 13 | The maternal-to-zygotic transition: a play in two acts | Development (Cambridge) | 2009 | 963 |
| 14 | Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations | Nature Communications | 2018 | 958 |
| 15 | Stem cell concepts renew cancer research | Blood | 2008 | 921 |
| 16 | The Evolutionary Landscape of Alternative Splicing in Vertebrate Species | Science | 2012 | 905 |
| 17 | Stem cell gene expression programs influence clinical outcome in human leukemia | Nature Medicine | 2011 | 894 |
| 18 | Diversity and Complexity in DNA Recognition by Transcription Factors | Science | 2009 | 874 |
| 19 | Copy number variation and selection during reprogramming to pluripotency | Nature | 2011 | 870 |
| 20 | An empirical framework for binary interactome mapping | Nature Methods | 2009 | 800 |
| 21 | Deciphering the splicing code | Nature | 2010 | 781 |
| 22 | A Census of Human Soluble Protein Complexes | Cell | 2012 | 781 |
| 23 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes | Nature | 2012 | 761 |
| 24 | ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function | Neuron | 2015 | 716 |
| 25 | Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients | Science Immunology | 2020 | 714 |
| 26 | Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder | Nature Neuroscience | 2017 | 691 |
| 27 | Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system | Nature | 2013 | 689 |
| 28 | SAINT: probabilistic scoring of affinity purification–mass spectrometry data | Nature Methods | 2011 | 647 |
| 29 | Gli Proteins in Development and Disease | Annual Review of Cell and Developmental Biology | 2011 | 603 |
| 30 | Distinct routes of lineage development reshape the human blood hierarchy across ontogeny | Science | 2016 | 597 |
| 31 | High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies | Molecular Cell | 2018 | 583 |
| 32 | 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark | Nature | 2013 | 580 |
| 33 | Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences | Cell | 2008 | 552 |
| 34 | Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia | Cancer Cell | 2011 | 546 |
| 35 | The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway | Journal of Immunology | 2009 | 501 |
| 36 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 37 | Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation | PLoS Pathogens | 2010 | 488 |
| 38 | Panorama of ancient metazoan macromolecular complexes | Nature | 2015 | 478 |
| 39 | RBPDB: a database of RNA-binding specificities | Nucleic Acids Research | 2011 | 477 |
| 40 | Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease | Microbiology and Molecular Biology Reviews | 2011 | 448 |
| 41 | Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 | American Journal of Medical Genetics, Part A | 2015 | 447 |
| 42 | The shieldin complex mediates 53BP1-dependent DNA repair | Nature | 2018 | 445 |
| 43 | Studying “Invisible” Excited Protein States in Slow Exchange with a Major State Conformation | Journal of the American Chemical Society | 2012 | 430 |
| 44 | Tracing the origins of relapse in acute myeloid leukaemia to stem cells | Nature | 2017 | 424 |
| 45 | A dimerization-dependent mechanism drives RAF catalytic activation | Nature | 2009 | 420 |
| 46 | Mechanisms of Antifungal Drug Resistance | Cold Spring Harbor Perspectives in Medicine | 2015 | 419 |
| 47 | Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins | Nature Biotechnology | 2009 | 418 |
| 48 | A Library of Yeast Transcription Factor Motifs Reveals a Widespread Function for Rsc3 in Targeting Nucleosome Exclusion at Promoters | Molecular Cell | 2008 | 415 |
| 49 | Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test | Genetics in Medicine | 2018 | 404 |
| 50 | NMR spectroscopy brings invisible protein states into focus | Nature Chemical Biology | 2009 | 403 |
