| # | Title | Journal | Year | Citations |
|---|
| 1 | Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4 | Science | 1995 | 2,587 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 3 | Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death | Nature | 2001 | 1,212 |
| 4 | TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES | Annual Review of Immunology | 2005 | 1,204 |
| 5 | Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry | Nature Immunology | 2010 | 1,125 |
| 6 | The Genome of the Sea Urchin Strongylocentrotus purpuratus | Science | 2006 | 1,018 |
| 7 | Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro | Immunity | 2002 | 1,003 |
| 8 | Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations | Nature Communications | 2018 | 958 |
| 9 | The X-files in immunity: sex-based differences predispose immune responses | Nature Reviews Immunology | 2008 | 883 |
| 10 | Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia | Nature Medicine | 2007 | 804 |
| 11 | BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis | Cell | 2018 | 802 |
| 12 | Nod-like proteins in immunity, inflammation and disease | Nature Immunology | 2006 | 794 |
| 13 | Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice | Immunity | 1997 | 778 |
| 14 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 15 | The NLR Gene Family: A Standard Nomenclature | Immunity | 2008 | 761 |
| 16 | Functional variants of OCTN cation transporter genes are associated with Crohn disease | Nature Genetics | 2004 | 749 |
| 17 | Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients | Science Immunology | 2020 | 714 |
| 18 | Regulation of cancer cell migration and bone metastasis by RANKL | Nature | 2006 | 709 |
| 19 | Mechanism of hard-nanomaterial clearance by the liver | Nature Materials | 2016 | 686 |
| 20 | Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection | Journal of Experimental Medicine | 2008 | 681 |
| 21 | Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA | Molecular Cell | 2003 | 611 |
| 22 | The ctenophore genome and the evolutionary origins of neural systems | Nature | 2014 | 606 |
| 23 | Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution | Nature Genetics | 2013 | 588 |
| 24 | Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function | Science | 1997 | 543 |
| 25 | NOD proteins: regulators of inflammation in health and disease | Nature Reviews Immunology | 2014 | 525 |
| 26 | CEACAM1 regulates TIM-3-mediated tolerance and exhaustion | Nature | 2015 | 525 |
| 27 | Guidelines for the use of flow cytometry and cell sorting in immunological studies* | European Journal of Immunology | 2017 | 505 |
| 28 | The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses | Nature Immunology | 2003 | 479 |
| 29 | IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics | Nature | 2012 | 474 |
| 30 | The shieldin complex mediates 53BP1-dependent DNA repair | Nature | 2018 | 445 |
| 31 | Modulating immunity as a therapy for bacterial infections | Nature Reviews Microbiology | 2012 | 439 |
| 32 | Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism | Nature Immunology | 2005 | 437 |
| 33 | Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues | Nature Immunology | 2005 | 434 |
| 34 | Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine | Immunity | 2011 | 412 |
| 35 | Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity | Blood | 2012 | 406 |
| 36 | Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity | Nature Medicine | 2003 | 404 |
| 37 | Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells | Cell | 2014 | 375 |
| 38 | Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens | Nature Immunology | 2013 | 368 |
| 39 | Heterogeneity among DN1 Prothymocytes Reveals Multiple Progenitors with Different Capacities to Generate T Cell and Non-T Cell Lineages | Immunity | 2004 | 360 |
| 40 | A global scientific strategy to cure hepatitis B | The Lancet Gastroenterology and Hepatology | 2019 | 342 |
| 41 | Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro | Nature Immunology | 2004 | 336 |
| 42 | Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy | Science Translational Medicine | 2015 | 334 |
| 43 | Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program | Cell Host and Microbe | 2012 | 331 |
| 44 | A Genetic Map of the Response to DNA Damage in Human Cells | Cell | 2020 | 324 |
| 45 | T cell co-stimulatory molecules other than CD28 | Current Opinion in Immunology | 1999 | 320 |
| 46 | 4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy | Journal of Immunology | 2001 | 319 |
| 47 | Interferon-α2b Treatment for COVID-19 | Frontiers in Immunology | 2020 | 314 |
| 48 | Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction | Immunity | 2004 | 308 |
| 49 | The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences | PLoS ONE | 2008 | 308 |
| 50 | Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8 + T-cell immunity | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 298 |
