| # | Title | Journal | Year | Citations |
|---|
| 1 | Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations | Journal of the Neurological Sciences | 1973 | 2,474 |
| 2 | Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine | Nature | 1991 | 1,967 |
| 3 | Antipsychotic drug doses and neuroleptic/dopamine receptors | Nature | 1976 | 1,560 |
| 4 | Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1 | Nature | 1991 | 1,103 |
| 5 | Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties | Free Radical Biology and Medicine | 2004 | 876 |
| 6 | The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease | Clinica Chimica Acta | 1995 | 819 |
| 7 | Dopamine receptor pharmacology | Trends in Pharmacological Sciences | 1994 | 807 |
| 8 | Dopamine receptors and the dopamine hypothesis of schizophrenia | Synapse | 1987 | 792 |
| 9 | A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11 | Gene | 1993 | 731 |
| 10 | Guidelines on nicotine dose selection for in vivo research | Psychopharmacology | 2007 | 694 |
| 11 | Characterization of Apelin, the Ligand for the APJ Receptor | Journal of Neurochemistry | 2001 | 572 |
| 12 | G-Protein-coupled receptor oligomerization and its potential for drug discovery | Nature Reviews Drug Discovery | 2002 | 552 |
| 13 | Human dopamine D1 receptor encoded by an intronless gene on chromosome 5 | Nature | 1990 | 470 |
| 14 | Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics | Toxicology | 2002 | 467 |
| 15 | D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 452 |
| 16 | Receptor basis for dopaminergic supersensitivity in Parkinson's disease | Nature | 1978 | 450 |
| 17 | Direct binding and functional coupling of α-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis | FASEB Journal | 2001 | 407 |
| 18 | Discovery of a receptor related to the galanin receptors | FEBS Letters | 1999 | 406 |
| 19 | Direct protein–protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors | Nature | 2000 | 403 |
| 20 | Human brain dopamine receptors in children and aging adults | Synapse | 1987 | 396 |
| 21 | Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal | Journal of Biological Chemistry | 2004 | 391 |
| 22 | Malignant hyperthermia: A statistical review | Canadian Anaesthetists' Society Journal | 1970 | 387 |
| 23 | Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method | Pharmacogenetics and Genomics | 2000 | 376 |
| 24 | The dopamine D4 receptor: one decade of research | European Journal of Pharmacology | 2000 | 373 |
| 25 | Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people | Lancet, The | 1998 | 367 |
| 26 | Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity*1 | Clinical Pharmacology and Therapeutics | 2004 | 366 |
| 27 | The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds☆ | Toxicology Letters | 1994 | 362 |
| 28 | Nicotine metabolism defect reduces smoking | Nature | 1998 | 359 |
| 29 | Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains | Nature | 1978 | 350 |
| 30 | A METHOD FOR THE DETECTION OF ATYPICAL FORMS OF HUMAN SERUM CHOLINESTERASE. DETERMINATION OF DIBUCAINE NUMBERS | Canadian Journal of Biochemistry and Physiology | 1957 | 329 |
| 31 | Identification and cloning of three novel human G protein-coupled receptor genes GPR52, ΨGPR53 and GPR55: GPR55 is extensively expressed in human brain | Molecular Brain Research | 1999 | 328 |
| 32 | Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4 | Neuropsychopharmacology | 1992 | 328 |
| 33 | Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins | Free Radical Biology and Medicine | 2006 | 321 |
| 34 | Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1 | Pharmacogenetics and Genomics | 1992 | 306 |
| 35 | An Animal Model of Genetic Vulnerability to Behavioral Disinhibition and Responsiveness to Reward-Related Cues: Implications for Addiction | Neuropsychopharmacology | 2010 | 303 |
| 36 | A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes | Journal of Pharmacology and Experimental Therapeutics | 1997 | 300 |
| 37 | Endogenous dopamine lowers the dopamine D2 receptor density as measured by [3H]raclopride: Implications for positron emission tomography of the human brain | Synapse | 1989 | 292 |
| 38 | Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases | Neuropsychopharmacology | 1987 | 289 |
| 39 | A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors | Nature | 1992 | 287 |
| 40 | 5-HT and alcohol abuse | Trends in Pharmacological Sciences | 1992 | 283 |
| 41 | Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries | Molecular Pharmacology | 2006 | 283 |
| 42 | Dopamine receptors and transporters in Parkinson's disease and schizophrenia | FASEB Journal | 1990 | 282 |
| 43 | Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians | Pharmacogenetics and Genomics | 2004 | 279 |
| 44 | The use of caffeine for enzyme assays: A critical appraisal | Clinical Pharmacology and Therapeutics | 1993 | 277 |
| 45 | Discovery of Three Novel G-Protein-Coupled Receptor Genes | Genomics | 1998 | 271 |
| 46 | Tactile, acoustic and vestibular systems sum to elicit the startle reflex | Neuroscience and Biobehavioral Reviews | 2002 | 271 |
| 47 | Variability in caffeine metabolism | Clinical Pharmacology and Therapeutics | 1983 | 267 |
| 48 | Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors | Molecular Psychiatry | 1998 | 267 |
| 49 | Neurogenesis in the Dentate Gyrus of the Rat Following Electroconvulsive Shock Seizures | Experimental Neurology | 2000 | 267 |
| 50 | Development of a New Pharmacological Seizure Model: Effects of Anticonvulsants on Cortical‐and Amygdala‐Kindled Seizures in the Rat | Epilepsia | 1980 | 263 |
