| # | Title | Journal | Year | Citations |
|---|
| 1 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) | JAMA - Journal of the American Medical Association | 2016 | 16,554 |
| 2 | Multiple Organ Dysfunction Score | Critical Care Medicine | 1995 | 3,338 |
| 3 | Genomic responses in mouse models poorly mimic human inflammatory diseases | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 2,518 |
| 4 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS) | Surgery | 2011 | 1,703 |
| 5 | Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery | Surgery | 2011 | 1,596 |
| 6 | Teaching Surgical Skills — Changes in the Wind | New England Journal of Medicine | 2006 | 1,492 |
| 7 | No surgical innovation without evaluation: the IDEAL recommendations | Lancet, The | 2009 | 1,450 |
| 8 | The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis | Intensive Care Medicine | 2010 | 1,180 |
| 9 | Traumatic spinal cord injury | Nature Reviews Disease Primers | 2017 | 1,138 |
| 10 | Measuring the whole or the parts? | Journal of Hand Therapy | 2001 | 1,121 |
| 11 | Functional Evaluation of Complete Sciatic, Peroneal, and Posterior Tibial Nerve Lesions in the Rat | Plastic and Reconstructive Surgery | 1989 | 1,086 |
| 12 | A clinical case definition of post-COVID-19 condition by a Delphi consensus | Lancet Infectious Diseases, The | 2022 | 1,068 |
| 13 | A genomic storm in critically injured humans | Journal of Experimental Medicine | 2011 | 1,040 |
| 14 | Accuracy of Pedicular Screw Placement In Vivo | Spine | 1990 | 1,034 |
| 15 | The development of a comorbidity index with physical function as the outcome | Journal of Clinical Epidemiology | 2005 | 969 |
| 16 | Testing technical skill via an innovative “bench station” examination | American Journal of Surgery | 1997 | 937 |
| 17 | Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization | Science | 2008 | 903 |
| 18 | Early versus Delayed Decompression for Traumatic Cervical Spinal Cord Injury: Results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS) | PLoS ONE | 2012 | 883 |
| 19 | Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression | Biological Psychiatry | 2008 | 865 |
| 20 | Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit | Lancet Respiratory Medicine,the | 2014 | 864 |
| 21 | Objective structured assessment of technical skill (OSATS) for surgical residents | British Journal of Surgery | 1997 | 827 |
| 22 | Autologous Transplantation of Bone Marrow Cells Improves Damaged Heart Function | Circulation | 1999 | 818 |
| 23 | Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study | Journal of Clinical Oncology | 2002 | 798 |
| 24 | A Consensus Molecular Classification of Muscle-invasive Bladder Cancer | European Urology | 2020 | 741 |
| 25 | Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease | Nature Genetics | 2001 | 730 |
| 26 | Deep brain stimulation: current challenges and future directions | Nature Reviews Neurology | 2019 | 721 |
| 27 | Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 | JAMA Oncology | 2022 | 719 |
| 28 | The pedunculopontine nucleus and Parkinson's disease | Brain | 2000 | 701 |
| 29 | Pain-related neurons in the human cingulate cortex | Nature Neuroscience | 1999 | 651 |
| 30 | Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa | Nature Genetics | 2019 | 641 |
| 31 | Traumatic Spinal Cord Injury—Repair and Regeneration | Neurosurgery | 2017 | 554 |
| 32 | Introduction of Surgical Safety Checklists in Ontario, Canada | New England Journal of Medicine | 2014 | 547 |
| 33 | Teaching Surgical Skills: What Kind of Practice Makes Perfect? | Annals of Surgery | 2006 | 546 |
| 34 | High-frequency Synchronization of Neuronal Activity in the Subthalamic Nucleus of Parkinsonian Patients with Limb Tremor | Journal of Neuroscience | 2000 | 538 |
| 35 | Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines | World Journal of Emergency Surgery | 2020 | 533 |
| 36 | Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord | Biomaterials | 2006 | 521 |
| 37 | Pre–B cell colony–enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis | Journal of Clinical Investigation | 2004 | 521 |
| 38 | Probing and Regulating Dysfunctional Circuits Using Deep Brain Stimulation | Neuron | 2013 | 519 |
| 39 | Prognostic Role of Platelet to Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis | Cancer Epidemiology Biomarkers and Prevention | 2014 | 519 |
| 40 | A Cortical Network Sensitive to Stimulus Salience in a Neutral Behavioral Context Across Multiple Sensory Modalities | Journal of Neurophysiology | 2002 | 518 |
| 41 | Assessment of technical skills transfer from the bench training model to the human model | American Journal of Surgery | 1999 | 500 |
| 42 | INNOMINATE OSTEOTOMY IN THE TREATMENT OF CONGENITAL DISLOCATION AND SUBLUXATION OF THE HIP | Journal of Bone and Joint Surgery: British Volume | 1961 | 497 |
| 43 | GRADE guidelines: 13. Preparing Summary of Findings tables and evidence profiles—continuous outcomes | Journal of Clinical Epidemiology | 2013 | 495 |
| 44 | Training and simulation for patient safety | Quality and Safety in Health Care | 2010 | 491 |
| 45 | A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury | Journal of Neurotrauma | 2011 | 490 |
| 46 | Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome | Critical Care Medicine | 2001 | 477 |
| 47 | Analysis of Administrative Data Finds Endoscopist Quality Measures Associated With Postcolonoscopy Colorectal Cancer | Gastroenterology | 2011 | 476 |
| 48 | MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study | Lancet Neurology, The | 2013 | 475 |
| 49 | Gender and Bladder Cancer: A Collaborative Review of Etiology, Biology, and Outcomes | European Urology | 2016 | 460 |
| 50 | 5-year Results of a Prospective Study of Percutaneous Transluminal Angioplasty | Annals of Surgery | 1987 | 458 |
