| # | Title | Journal | Year | Citations |
|---|
| 1 | Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries | JAMA - Journal of the American Medical Association | 2016 | 3,568 |
| 2 | Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) | Intensive Care Medicine | 2020 | 1,536 |
| 3 | Acute respiratory distress syndrome | Nature Reviews Disease Primers | 2019 | 1,364 |
| 4 | High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2013 | 1,209 |
| 5 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury | Cell | 2008 | 1,164 |
| 6 | The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material | Intensive Care Medicine | 2012 | 1,112 |
| 7 | Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure | European Respiratory Journal | 2017 | 1,014 |
| 8 | Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2013 | 999 |
| 9 | Acute Respiratory Distress Syndrome | JAMA - Journal of the American Medical Association | 2018 | 983 |
| 10 | Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit | Lancet Respiratory Medicine,the | 2014 | 864 |
| 11 | Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) | Critical Care Medicine | 2020 | 816 |
| 12 | Titration and Implementation of Neurally Adjusted Ventilatory Assist in Critically Ill Patients | Chest | 2009 | 736 |
| 13 | Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 671 |
| 14 | Physical Complications in Acute Lung Injury Survivors | Critical Care Medicine | 2014 | 480 |
| 15 | Formal guidelines: management of acute respiratory distress syndrome | Annals of Intensive Care | 2019 | 478 |
| 16 | Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus ‘conventional’ protective ventilation (6 ml/kg) in severe ARDS | Intensive Care Medicine | 2013 | 474 |
| 17 | Quality of life in adult survivors of critical illness: A systematic review of the literature | Intensive Care Medicine | 2005 | 460 |
| 18 | Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis | BMJ: British Medical Journal | 2007 | 388 |
| 19 | Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial | JAMA - Journal of the American Medical Association | 2018 | 367 |
| 20 | Quality of life after acute respiratory distress syndrome: a meta-analysis | Intensive Care Medicine | 2006 | 316 |
| 21 | Recruitment Maneuvers for Acute Lung Injury | American Journal of Respiratory and Critical Care Medicine | 2008 | 294 |
| 22 | Critically Ill Patients With Severe Acute Respiratory Syndrome | JAMA - Journal of the American Medical Association | 2003 | 290 |
| 23 | Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update | Critical Care Medicine | 2021 | 289 |
| 24 | Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity | Intensive Care Medicine | 2015 | 286 |
| 25 | Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure | JAMA - Journal of the American Medical Association | 2020 | 283 |
| 26 | Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults* | Critical Care Medicine | 2015 | 268 |
| 27 | Transmission of Severe Acute Respiratory Syndrome during Intubation and Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2004 | 265 |
| 28 | Projected incidence of mechanical ventilation in Ontario to 2026: Preparing for the aging baby boomers* | Critical Care Medicine | 2005 | 263 |
| 29 | Management of Adult Patients Supported with Venovenous Extracorporeal Membrane Oxygenation (VV ECMO): Guideline from the Extracorporeal Life Support Organization (ELSO) | ASAIO Journal | 2021 | 261 |
| 30 | High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis | Intensive Care Medicine | 2019 | 254 |
| 31 | Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications | JAMA - Journal of the American Medical Association | 2019 | 251 |
| 32 | Do Intensivist Staffing Patterns Influence Hospital Mortality Following ICU Admission? A Systematic Review and Meta-Analyses* | Critical Care Medicine | 2013 | 250 |
| 33 | Liberation From Mechanical Ventilation in Critically Ill Adults: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline | Chest | 2017 | 248 |
| 34 | Prone position in ARDS patients: why, when, how and for whom | Intensive Care Medicine | 2020 | 243 |
| 35 | Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit* | Critical Care Medicine | 2017 | 235 |
| 36 | Acute respiratory distress syndrome: Underrecognition by clinicians and diagnostic accuracy of three clinical definitions* | Critical Care Medicine | 2005 | 234 |
| 37 | Protected Code Stroke | Stroke | 2020 | 206 |
| 38 | Mechanical Ventilation Management during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. An International Multicenter Prospective Cohort | American Journal of Respiratory and Critical Care Medicine | 2019 | 200 |
| 39 | Fifty Years of Research in ARDS.The Epidemiology of Acute Respiratory Distress Syndrome. A 50th Birthday Review | American Journal of Respiratory and Critical Care Medicine | 2017 | 191 |
| 40 | Atelectasis Causes Vascular Leak and Lethal Right Ventricular Failure in Uninjured Rat Lungs | American Journal of Respiratory and Critical Care Medicine | 2003 | 185 |
| 41 | Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis | Critical Care | 2021 | 185 |
| 42 | Worldwide Survey of the “Assessing Pain, Both Spontaneous Awakening and Breathing Trials, Choice of Drugs, Delirium Monitoring/Management, Early Exercise/Mobility, and Family Empowerment” (ABCDEF) Bundle | Critical Care Medicine | 2017 | 178 |
| 43 | Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis | Intensive Care Medicine | 2016 | 176 |
| 44 | Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study | Intensive Care Medicine | 2019 | 175 |
| 45 | Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study | Intensive Care Medicine | 2015 | 174 |
| 46 | The Impact of Hospital and ICU Organizational Factors on Outcome in Critically Ill Patients | Critical Care Medicine | 2015 | 170 |
| 47 | Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19 | JAMA - Journal of the American Medical Association | 2021 | 169 |
| 48 | The Extracorporeal Life Support Organization Maastricht Treaty for Nomenclature in Extracorporeal Life Support. A Position Paper of the Extracorporeal Life Support Organization | American Journal of Respiratory and Critical Care Medicine | 2018 | 165 |
| 49 | Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial | Intensive Care Medicine | 2004 | 164 |
| 50 | FiftyYearsofResearchinARDS.Setting Positive End-Expiratory Pressure in Acute Respiratory Distress Syndrome | American Journal of Respiratory and Critical Care Medicine | 2017 | 162 |
