| # | Title | Journal | Year | Citations |
|---|
| 1 | Nipah Virus: A Recently Emergent Deadly Paramyxovirus | Science | 2000 | 1,079 |
| 2 | Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome | Lancet, The | 2003 | 956 |
| 3 | Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors | Nature Genetics | 2017 | 849 |
| 4 | Emergence and global spread of epidemic healthcare-associated Clostridium difficile | Nature Genetics | 2013 | 669 |
| 5 | Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project | Blood | 2009 | 656 |
| 6 | Breast cancer prognostic classification in the molecular era: the role of histological grade | Breast Cancer Research | 2010 | 650 |
| 7 | A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets | Gut | 2012 | 562 |
| 8 | Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes | Nature Genetics | 2012 | 560 |
| 9 | Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists | Modern Pathology | 2011 | 545 |
| 10 | Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage | Nature Genetics | 2015 | 466 |
| 11 | Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers | Nature Genetics | 2013 | 426 |
| 12 | Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection | Lancet, The | 2003 | 423 |
| 13 | Exome sequencing of liver fluke–associated cholangiocarcinoma | Nature Genetics | 2012 | 412 |
| 14 | A bacterial cell-cell communication signal with cross-kingdom structural analogues | Molecular Microbiology | 2003 | 393 |
| 15 | Outbreak of Nipah-virus infection among abattoir workers in Singapore | Lancet, The | 1999 | 388 |
| 16 | Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil | Gastroenterology | 2013 | 381 |
| 17 | Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma | Gut | 2017 | 359 |
| 18 | Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore | Emerging Infectious Diseases | 2003 | 355 |
| 19 | An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma | Cancer Cell | 2011 | 347 |
| 20 | Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells | Immunity | 2019 | 336 |
| 21 | Phyllodes tumours of the breast: a consensus review | Histopathology | 2016 | 329 |
| 22 | Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma | Cell | 2020 | 329 |
| 23 | Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma | Gut | 2012 | 307 |
| 24 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy | Gastroenterology | 2011 | 304 |
| 25 | Seasonal trends of viral respiratory tract infections in the tropics | Epidemiology and Infection | 1998 | 280 |
| 26 | Identification of Circulating MicroRNA Signatures for Breast Cancer Detection | Clinical Cancer Research | 2013 | 258 |
| 27 | Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: Its role in tumor progression and apoptosis | BMC Gastroenterology | 2003 | 244 |
| 28 | Capsular Serotype K1 or K2, Rather than magA and rmpA , Is a Major Virulence Determinant for Klebsiella pneumoniae Liver Abscess in Singapore and Taiwan | Journal of Clinical Microbiology | 2007 | 241 |
| 29 | International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins | Modern Pathology | 2011 | 239 |
| 30 | Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease | Immunity | 2021 | 233 |
| 31 | A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures | Immunity | 2016 | 232 |
| 32 | Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma | Gut | 2019 | 228 |
| 33 | Large artery ischaemic stroke in severe acute respiratory syndrome (SARS) | Journal of Neurology | 2004 | 222 |
| 34 | Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins | Journal of Clinical Pathology | 2012 | 220 |
| 35 | Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer | Modern Pathology | 2010 | 209 |
| 36 | Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore | Emerging Infectious Diseases | 2003 | 201 |
| 37 | Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2 | Nature | 2017 | 199 |
| 38 | Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention | Nature Biomedical Engineering | 2018 | 184 |
| 39 | Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore | Modern Pathology | 2004 | 174 |
| 40 | Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma | Nature Genetics | 2014 | 172 |
| 41 | Genomic landscapes of breast fibroepithelial tumors | Nature Genetics | 2015 | 167 |
| 42 | Clinical Validation of an Ultra High-Throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells | PLoS ONE | 2014 | 165 |
| 43 | Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2 | Science Translational Medicine | 2017 | 165 |
| 44 | Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10‐year update and subset analysis | Cancer | 2015 | 163 |
| 45 | TFE3 Break-apart FISH Has a Higher Sensitivity for Xp11.2 Translocation–associated Renal Cell Carcinoma Compared With TFE3 or Cathepsin K Immunohistochemical Staining Alone | American Journal of Surgical Pathology | 2013 | 158 |
| 46 | Novel therapeutic targets on the horizon for lung cancer | Lancet Oncology, The | 2016 | 156 |
| 47 | MicroRNA-Mediated Down-Regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg Cells: A Potential Pathogenetic Lesion in Hodgkin Lymphomas | American Journal of Pathology | 2008 | 154 |
| 48 | Regulatory crosstalk between lineage-survival oncogenesKLF5, GATA4andGATA6cooperatively promotes gastric cancer development | Gut | 2015 | 148 |
| 49 | Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting | Biochimica Et Biophysica Acta - Biomembranes | 2013 | 147 |
| 50 | Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma | Nature Medicine | 2017 | 141 |
