| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Getting to the site of inflammation: the leukocyte adhesion cascade updated | Nature Reviews Immunology | 2007 | 3,547 |
| 4 | Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma | Thyroid | 2015 | 1,738 |
| 5 | International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study | Lancet, The | 2018 | 1,487 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 7 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target | American Journal of Gastroenterology | 2015 | 1,425 |
| 8 | Diagnosing COVID-19: The Disease and Tools for Detection | ACS Nano | 2020 | 1,360 |
| 9 | Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety | American Journal of Clinical Nutrition | 1999 | 1,312 |
| 10 | Ancient human genomes suggest three ancestral populations for present-day Europeans | Nature | 2014 | 1,179 |
| 11 | Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry | Nature Immunology | 2010 | 1,125 |
| 12 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 13 | A major role for VCAM-1, but not ICAM-1, in early atherosclerosis | Journal of Clinical Investigation | 2001 | 989 |
| 14 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 15 | Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations | Nature Communications | 2018 | 958 |
| 16 | Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel | American Journal of Gastroenterology | 2012 | 948 |
| 17 | Cancer immunotherapy: the beginning of the end of cancer? | BMC Medicine | 2016 | 908 |
| 18 | B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies | Nature Medicine | 2011 | 858 |
| 19 | Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1? generation | Clinical and Experimental Immunology | 2006 | 832 |
| 20 | Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695 | Journal of Biological Chemistry | 2001 | 820 |
| 21 | Guidelines for terms related to chemical speciation and fractionation of elements. Definitions, structural aspects, and methodological approaches (IUPAC Recommendations 2000) | Pure and Applied Chemistry | 2000 | 810 |
| 22 | Nod-like proteins in immunity, inflammation and disease | Nature Immunology | 2006 | 794 |
| 23 | The NLR Gene Family: A Standard Nomenclature | Immunity | 2008 | 761 |
| 24 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes | Nature | 2012 | 761 |
| 25 | Functional classification of interferon-stimulated genes identified using microarrays | Journal of Leukocyte Biology | 2001 | 698 |
| 26 | The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development | Cell | 2000 | 674 |
| 27 | WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1 | Molecular Cell | 2014 | 650 |
| 28 | Fructose, insulin resistance, and metabolic dyslipidemia | Nutrition and Metabolism | 2005 | 639 |
| 29 | Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization | Neuron | 2000 | 631 |
| 30 | Progesterone induces adult mammary stem cell expansion | Nature | 2010 | 608 |
| 31 | Absorption of three wine-related polyphenols in three different matrices by healthy subjects | Clinical Biochemistry | 2003 | 607 |
| 32 | MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia | PLoS ONE | 2006 | 592 |
| 33 | Patterns of Vascular Cell Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 Expression in Rabbit and Mouse Atherosclerotic Lesions and at Sites Predisposed to Lesion Formation | Circulation Research | 1999 | 578 |
| 34 | Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer | Gene Therapy | 1999 | 576 |
| 35 | Mass Spectrometry as a Diagnostic and a Cancer Biomarker Discovery Tool | Molecular and Cellular Proteomics | 2004 | 568 |
| 36 | SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 558 |
| 37 | Integrin-linked kinase: a cancer therapeutic target unique among its ILK | Nature Reviews Cancer | 2005 | 554 |
| 38 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers | Clinical Chemistry | 2008 | 539 |
| 39 | Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects | Science | 2004 | 532 |
| 40 | Novel therapeutic applications of cardiac glycosides | Nature Reviews Drug Discovery | 2008 | 529 |
| 41 | The Emerging Role of Valve Interstitial Cell Phenotypes in Regulating Heart Valve Pathobiology | American Journal of Pathology | 2007 | 528 |
| 42 | NOD proteins: regulators of inflammation in health and disease | Nature Reviews Immunology | 2014 | 525 |
| 43 | Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization | Nature Neuroscience | 2000 | 523 |
| 44 | The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 516 |
| 45 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 46 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 47 | Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions | Nature Genetics | 2010 | 479 |
| 48 | HER2 testing in gastric cancer: a practical approach | Modern Pathology | 2012 | 478 |
| 49 | The updated biology of hypoxia-inducible factor | EMBO Journal | 2012 | 473 |
| 50 | Identifying and Characterizing circRNA-Protein Interaction | Theranostics | 2017 | 467 |
