# | Title | Journal | Year | Citations |
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1 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
2 | Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress | Pharmacology Biochemistry and Behavior | 2006 | 285 |
3 | Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia | International Immunopharmacology | 2005 | 248 |
4 | Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms | Life Sciences | 2007 | 207 |
5 | Silibinin prevents amyloid β peptide‐induced memory impairment and oxidative stress in mice | British Journal of Pharmacology | 2009 | 169 |
6 | Hepatoprotective Effects of Apple Polyphenols on CCl4-Induced Acute Liver Damage in Mice | Journal of Agricultural and Food Chemistry | 2010 | 162 |
7 | One pot synthesis of highly luminescent polyethylene glycol anchored carbon dots functionalized with a nuclear localization signal peptide for cell nucleus imaging | Nanoscale | 2015 | 161 |
8 | Doxorubicin conjugated functionalizable carbon dots for nucleus targeted delivery and enhanced therapeutic efficacy | Nanoscale | 2016 | 140 |
9 | Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement | Neuropharmacology | 2009 | 136 |
10 | Differential effects of ginsenosides on NO and TNF-α production by LPS-activated N9 microglia | International Immunopharmacology | 2007 | 130 |
11 | 3-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: Microwave-assisted synthesis and biological evaluation | European Journal of Medicinal Chemistry | 2015 | 128 |
12 | Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia | Autophagy | 2019 | 128 |
13 | Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-κB, JNK and p38 MAPK inactivation | European Journal of Pharmacology | 2008 | 126 |
14 | Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure | Behavioural Brain Research | 2013 | 126 |
15 | Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities | European Journal of Medicinal Chemistry | 2014 | 126 |
16 | DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy | Cancers | 2020 | 124 |
17 | Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression | Clinica Chimica Acta | 2010 | 121 |
18 | Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice | Naunyn-Schmiedeberg's Archives of Pharmacology | 2008 | 120 |
19 | High Co-loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic Therapy | ACS Nano | 2019 | 116 |
20 | Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways | Neuropharmacology | 2014 | 112 |
21 | Antiangiogenic activity of β-eudesmol in vitro and in vivo | European Journal of Pharmacology | 2005 | 107 |
22 | The osteoprotective effect ofHerba epimedii(HEP) extractin vivoandin vitro | Evidence-based Complementary and Alternative Medicine | 2005 | 103 |
23 | Antidepressant-like effects of piperine and its derivative, antiepilepsirine | Journal of Asian Natural Products Research | 2007 | 103 |
24 | Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling | British Journal of Cancer | 2014 | 101 |
25 | Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism | International Immunopharmacology | 2009 | 98 |
26 | The combination of disulfiram and copper for cancer treatment | Drug Discovery Today | 2020 | 95 |
27 | Enhanced oral absorption and anticancer efficacy of cabazitaxel by overcoming intestinal mucus and epithelium barriers using surface polyethylene oxide (PEO) decorated positively charged polymer-lipid hybrid nanoparticles | Journal of Controlled Release | 2018 | 94 |
28 | The preparation, cytocompatibility, and in vitro biodegradation study of pure β-TCP on magnesium | Journal of Materials Science: Materials in Medicine | 2009 | 92 |
29 | Leptin Level and Oxidative Stress Contribute to Obesity-Induced Low Testosterone in Murine Testicular Tissue | Oxidative Medicine and Cellular Longevity | 2014 | 91 |
30 | Morphine Withdrawal Increases Glutamate Uptake and Surface Expression of Glutamate Transporter GLT1 at Hippocampal Synapses | Journal of Neuroscience | 2003 | 89 |
31 | The Relative Risk and Incidence of Immune Checkpoint Inhibitors Related Pneumonitis in Patients With Advanced Cancer: A Meta-Analysis | Frontiers in Pharmacology | 2018 | 88 |
32 | Antioxidant Activities of Chitobiose and Chitotriose | Biological and Pharmaceutical Bulletin | 2003 | 87 |
33 | Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide | International Immunopharmacology | 2010 | 87 |
34 | Sex difference in psychological behavior changes induced by long-term social isolation in mice | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2004 | 85 |
35 | In vitro activity of baicalein against Candida albicans biofilms | International Journal of Antimicrobial Agents | 2008 | 85 |
36 | Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells | Oncotarget | 2016 | 84 |
37 | T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway | Apoptosis: an International Journal on Programmed Cell Death | 2012 | 83 |
38 | Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice | Pharmacology Biochemistry and Behavior | 2006 | 82 |
39 | Large amino acid transporter 1 mediated glutamate modified docetaxel-loaded liposomes for glioma targeting | Colloids and Surfaces B: Biointerfaces | 2016 | 82 |
40 | Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family | Journal of Neurochemistry | 2011 | 81 |
41 | Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells | Food and Chemical Toxicology | 2008 | 80 |
42 | Sildenafil attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia | International Immunopharmacology | 2011 | 80 |
43 | Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML | Journal of Experimental Medicine | 2014 | 80 |
44 | Silver nanoparticles induce protective autophagy via Ca2+/CaMKKβ/AMPK/mTOR pathway in SH-SY5Y cells and rat brains | Nanotoxicology | 2019 | 80 |
45 | Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2014 | 79 |
46 | Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways | Neurotoxicity Research | 2016 | 79 |
47 | Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation | Journal of Neuroinflammation | 2020 | 79 |
48 | Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats | Pharmacology Biochemistry and Behavior | 2007 | 78 |
49 | PI3K/AKT/mTOR pathway-related long non-coding RNAs: roles and mechanisms in hepatocellular carcinoma | Pharmacological Research | 2020 | 78 |
50 | Direct in vivo Evidence of Protective Effects of Grape Seed Procyanidin Fractions and Other Antioxidants against Ethanol-Induced Oxidative DNA Damage in Mouse Brain Cells | Journal of Agricultural and Food Chemistry | 2007 | 77 |