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Top Articles

#TitleJournalYearCitations
1Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy20211,430
2Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stressPharmacology Biochemistry and Behavior2006285
3Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microgliaInternational Immunopharmacology2005248
4Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanismsLife Sciences2007207
5Silibinin prevents amyloid β peptide‐induced memory impairment and oxidative stress in miceBritish Journal of Pharmacology2009169
6Hepatoprotective Effects of Apple Polyphenols on CCl4-Induced Acute Liver Damage in MiceJournal of Agricultural and Food Chemistry2010162
7One pot synthesis of highly luminescent polyethylene glycol anchored carbon dots functionalized with a nuclear localization signal peptide for cell nucleus imagingNanoscale2015161
8Doxorubicin conjugated functionalizable carbon dots for nucleus targeted delivery and enhanced therapeutic efficacyNanoscale2016140
9Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatementNeuropharmacology2009136
10Differential effects of ginsenosides on NO and TNF-α production by LPS-activated N9 microgliaInternational Immunopharmacology2007130
113-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: Microwave-assisted synthesis and biological evaluationEuropean Journal of Medicinal Chemistry2015128
12Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemiaAutophagy2019128
13Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-κB, JNK and p38 MAPK inactivationEuropean Journal of Pharmacology2008126
14Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposureBehavioural Brain Research2013126
15Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activitiesEuropean Journal of Medicinal Chemistry2014126
16DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted TherapyCancers2020124
17Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depressionClinica Chimica Acta2010121
18Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in miceNaunyn-Schmiedeberg's Archives of Pharmacology2008120
19High Co-loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic TherapyACS Nano2019116
20Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathwaysNeuropharmacology2014112
21Antiangiogenic activity of β-eudesmol in vitro and in vivoEuropean Journal of Pharmacology2005107
22The osteoprotective effect ofHerba epimedii(HEP) extractin vivoandin vitroEvidence-based Complementary and Alternative Medicine2005103
23Antidepressant-like effects of piperine and its derivative, antiepilepsirineJournal of Asian Natural Products Research2007103
24Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signallingBritish Journal of Cancer2014101
25Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanismInternational Immunopharmacology200998
26The combination of disulfiram and copper for cancer treatmentDrug Discovery Today202095
27Enhanced oral absorption and anticancer efficacy of cabazitaxel by overcoming intestinal mucus and epithelium barriers using surface polyethylene oxide (PEO) decorated positively charged polymer-lipid hybrid nanoparticlesJournal of Controlled Release201894
28The preparation, cytocompatibility, and in vitro biodegradation study of pure β-TCP on magnesiumJournal of Materials Science: Materials in Medicine200992
29Leptin Level and Oxidative Stress Contribute to Obesity-Induced Low Testosterone in Murine Testicular TissueOxidative Medicine and Cellular Longevity201491
30Morphine Withdrawal Increases Glutamate Uptake and Surface Expression of Glutamate Transporter GLT1 at Hippocampal SynapsesJournal of Neuroscience200389
31The Relative Risk and Incidence of Immune Checkpoint Inhibitors Related Pneumonitis in Patients With Advanced Cancer: A Meta-AnalysisFrontiers in Pharmacology201888
32Antioxidant Activities of Chitobiose and ChitotrioseBiological and Pharmaceutical Bulletin200387
33Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharideInternational Immunopharmacology201087
34Sex difference in psychological behavior changes induced by long-term social isolation in miceProgress in Neuro-Psychopharmacology and Biological Psychiatry200485
35In vitro activity of baicalein against Candida albicans biofilmsInternational Journal of Antimicrobial Agents200885
36Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cellsOncotarget201684
37T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathwayApoptosis: an International Journal on Programmed Cell Death201283
38Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in micePharmacology Biochemistry and Behavior200682
39Large amino acid transporter 1 mediated glutamate modified docetaxel-loaded liposomes for glioma targetingColloids and Surfaces B: Biointerfaces201682
40Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide familyJournal of Neurochemistry201181
41Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cellsFood and Chemical Toxicology200880
42Sildenafil attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microgliaInternational Immunopharmacology201180
43Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AMLJournal of Experimental Medicine201480
44Silver nanoparticles induce protective autophagy via Ca2+/CaMKKβ/AMPK/mTOR pathway in SH-SY5Y cells and rat brainsNanotoxicology201980
45Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in miceProgress in Neuro-Psychopharmacology and Biological Psychiatry201479
46Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 PathwaysNeurotoxicity Research201679
47Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formationJournal of Neuroinflammation202079
48Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model ratsPharmacology Biochemistry and Behavior200778
49PI3K/AKT/mTOR pathway-related long non-coding RNAs: roles and mechanisms in hepatocellular carcinomaPharmacological Research202078
50Direct in vivo Evidence of Protective Effects of Grape Seed Procyanidin Fractions and Other Antioxidants against Ethanol-Induced Oxidative DNA Damage in Mouse Brain CellsJournal of Agricultural and Food Chemistry200777