| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2018 | 1,187 |
| 3 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2020 | 1,123 |
| 4 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2012 | 658 |
| 5 | Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women | Nature Medicine | 2012 | 624 |
| 6 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer | International Journal of Clinical Oncology | 2015 | 548 |
| 7 | Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice | Anesthesiology | 2009 | 455 |
| 8 | 2011 SOSORT guidelines: Orthopaedic and Rehabilitation treatment of idiopathic scoliosis during growth | Scoliosis | 2012 | 316 |
| 9 | Diagnostic outcomes of esophageal cancer by artificial intelligence using convolutional neural networks | Gastrointestinal Endoscopy | 2019 | 314 |
| 10 | Biliary reconstruction, its complications and management of biliary complications after adult liver transplantation: a systematic review of the incidence, risk factors and outcome | Transplant International | 2011 | 272 |
| 11 | Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice | Journal of Alzheimer's Disease | 2009 | 270 |
| 12 | Reduced Time Points to Calculate the Composite Index | Diabetes Care | 2010 | 199 |
| 13 | Electromagnetic Field Treatment Protects Against and Reverses Cognitive Impairment in Alzheimer's Disease Mice | Journal of Alzheimer's Disease | 2010 | 189 |
| 14 | Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer's Disease Transgenic Mice | Journal of Alzheimer's Disease | 2009 | 176 |
| 15 | ZNF384 -related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype | Haematologica | 2017 | 172 |
| 16 | Novel computer-assisted diagnosis system for endoscopic disease activity in patients with ulcerative colitis | Gastrointestinal Endoscopy | 2019 | 157 |
| 17 | Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab: A retrospective review and case–control study of 21 patients | Arthritis and Rheumatism | 2009 | 146 |
| 18 | Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients | Kidney International | 2014 | 142 |
| 19 | Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation | Nature Communications | 2012 | 140 |
| 20 | Enhanced cognitive activity—over and above social or physical activity—is required to protect Alzheimer’s mice against cognitive impairment, reduce Aβ deposition, and increase synaptic immunoreactivity | Neurobiology of Learning and Memory | 2007 | 137 |
| 21 | Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants | JAMA - Journal of the American Medical Association | 2019 | 137 |
| 22 | Baseline tumour necrosis factor alpha levels predict the necessity for dose escalation of infliximab therapy in patients with rheumatoid arthritis | Annals of the Rheumatic Diseases | 2011 | 131 |
| 23 | Update on the Japanese guidelines for the use of infliximab and etanercept in rheumatoid arthritis | Modern Rheumatology | 2007 | 130 |
| 24 | Short‐term outcomes of multicenter prospective cohort study of gastric endoscopic resection: ‘Real‐world evidence’ in Japan | Digestive Endoscopy | 2019 | 109 |
| 25 | Reduced Ghrelin Secretion in the Hypothalamus of Rats due to Cisplatin-Induced Anorexia | Endocrinology | 2010 | 105 |
| 26 | Impact of trough serum level on radiographic and clinical response to infliximab plus methotrexate in patients with rheumatoid arthritis: results from the RISING study | Modern Rheumatology | 2009 | 104 |
| 27 | Predicting the progression of cervical precursor lesions by human papillomavirus genotyping: A prospective cohort study | International Journal of Cancer | 2011 | 104 |
| 28 | CD5-positive diffuse large B-cell lymphoma: a retrospective study in 337 patients treated by chemotherapy with or without rituximab | Annals of Oncology | 2011 | 103 |
| 29 | Prognostic Role of Conversion Surgery for Unresectable Gastric Cancer | Annals of Surgical Oncology | 2015 | 103 |
| 30 | A prospective multicenter study on self-expandable metallic stents as a bridge to surgery for malignant colorectal obstruction in Japan: efficacy and safety in 312 patients | Surgical Endoscopy and Other Interventional Techniques | 2016 | 102 |
| 31 | GM-CSF Upregulated in Rheumatoid Arthritis Reverses Cognitive Impairment and Amyloidosis in Alzheimer Mice | Journal of Alzheimer's Disease | 2010 | 101 |
| 32 | Somatic Mutations in PIK3CA and Activation of AKT in Intraductal Tubulopapillary Neoplasms of the Pancreas | American Journal of Surgical Pathology | 2011 | 98 |
| 33 | Clinical Effectiveness of Tolvaptan in Patients With Acute Heart Failure and Renal Dysfunction | Journal of Cardiac Failure | 2016 | 92 |
| 34 | A nationwide survey on the epidemiology and clinical features of eosinophilic granulomatosis with polyangiitis (Churg-Strauss) in Japan | Modern Rheumatology | 2014 | 90 |
| 35 | Automated endoscopic detection and classification of colorectal polyps using convolutional neural networks | Therapeutic Advances in Gastroenterology | 2020 | 90 |
| 36 | New Bone Formation in Nongrafted Sinus Lifting With Space-Maintaining Management: A Novel Technique Using a Titanium Bone Fixation Device | Journal of Oral and Maxillofacial Surgery | 2012 | 88 |
| 37 | Electromagnetic Treatment to Old Alzheimer's Mice Reverses β-Amyloid Deposition, Modifies Cerebral Blood Flow, and Provides Selected Cognitive Benefit | PLoS ONE | 2012 | 88 |
| 38 | Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1 | Molecular Psychiatry | 2016 | 87 |
| 39 | Update on the Japanese guidelines for the use of infliximab and etanercept in rheumatoid arthritis | Modern Rheumatology | 2007 | 86 |
| 40 | A Japanese prospective multicenter study of self-expandable metal stent placement for malignant colorectal obstruction: short-term safety and efficacy within 7 days of stent procedure in 513 cases | Gastrointestinal Endoscopy | 2015 | 85 |
| 41 | Risk factors for postoperative pancreatic fistula after pancreaticoduodenectomy: the significance of the ratio of the main pancreatic duct to the pancreas body as a predictor of leakage | Journal of Hepato-Biliary-Pancreatic Sciences | 2010 | 82 |
| 42 | The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity | Leukemia Research | 2011 | 82 |
| 43 | Diagnosis using deep-learning artificial intelligence based on the endocytoscopic observation of the esophagus | Esophagus | 2019 | 80 |
| 44 | Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-α monoclonal antibody, infliximab | Rheumatology | 2008 | 79 |
| 45 | Cotinine Reduces Amyloid-β Aggregation and Improves Memory in Alzheimer's Disease Mice | Journal of Alzheimer's Disease | 2011 | 77 |
| 46 | The profile of Japanese Association for Acute Medicine – out‐of‐hospital cardiac arrest registry in 2014–2015 | Acute Medicine & Surgery | 2018 | 77 |
| 47 | Assertive case management versus enhanced usual care for people with mental health problems who had attempted suicide and were admitted to hospital emergency departments in Japan (ACTION-J): a multicentre, randomised controlled trial | Lancet Psychiatry,the | 2014 | 75 |
| 48 | Sex and Age Differences in the Bony Nasolacrimal Canal | JAMA Ophthalmology | 2007 | 74 |
| 49 | Indocyanine green fluorescence angiography of the reconstructed gastric tube during esophagectomy: efficacy of the 90-second rule | Ecological Management and Restoration | 2018 | 74 |
| 50 | S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors | PLoS ONE | 2011 | 73 |
