| # | Title | Journal | Year | Citations |
|---|
| 1 | The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis | Neuron | 2003 | 1,465 |
| 2 | Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed | Journal of Diabetes Science and Technology | 2008 | 853 |
| 3 | Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis | JAMA - Journal of the American Medical Association | 2019 | 753 |
| 4 | Chronic Cough as the Sole Presenting Manifestation of Bronchial Asthma | New England Journal of Medicine | 1979 | 582 |
| 5 | Diet-Induced Obesity Causes Severe but Reversible Leptin Resistance in Arcuate Melanocortin Neurons | Cell Metabolism | 2007 | 481 |
| 6 | Normotensive Ischemic Acute Renal Failure | New England Journal of Medicine | 2007 | 460 |
| 7 | Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease | Journal of Alzheimer's Disease | 2006 | 415 |
| 8 | The Enterococcus: a Model of Adaptability to Its Environment | Clinical Microbiology Reviews | 2019 | 357 |
| 9 | Changing Epidemiology of Infections in Patients with Neutropenia and Cancer: Emphasis on Gram-Positive and Resistant Bacteria | Clinical Infectious Diseases | 1999 | 355 |
| 10 | Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus | Science | 1987 | 344 |
| 11 | Crohn's disease and the mycobacterioses: a review and comparison of two disease entities | Clinical Microbiology Reviews | 1989 | 344 |
| 12 | Chromogranin A—Biological Function and Clinical Utility in Neuro Endocrine Tumor Disease | Annals of Surgical Oncology | 2010 | 325 |
| 13 | Distribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression | Clinical Cancer Research | 2006 | 314 |
| 14 | Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease | Journal of Alzheimer's Disease | 2006 | 291 |
| 15 | Minireview: G Protein-Coupled Estrogen Receptor-1, GPER-1: Its Mechanism of Action and Role in Female Reproductive Cancer, Renal and Vascular Physiology | Endocrinology | 2012 | 283 |
| 16 | Five-Year Survival in EGFR -Mutant Metastatic Lung Adenocarcinoma Treated with EGFR-TKIs | Journal of Thoracic Oncology | 2016 | 268 |
| 17 | Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis | Neuron | 2003 | 264 |
| 18 | Mechanisms of Disease: inflammation and the origins of cancer | Nature Clinical Practice Oncology | 2005 | 255 |
| 19 | Adverse Environmental Conditions in the Respiratory and Medical ICU Settings | Chest | 1994 | 253 |
| 20 | Acetaldehyde Adducts in Alcoholic Liver Disease | Oxidative Medicine and Cellular Longevity | 2010 | 253 |
| 21 | Body Fat Distribution and Sleep Apnea Severity in Women | Chest | 1995 | 252 |
| 22 | Daytime Hypertension in Obstructive Sleep Apnea | Chest | 1991 | 230 |
| 23 | A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy | Kidney International | 2010 | 219 |
| 24 | Environmental Noise as a Cause of Sleep Disruption in an Intermediate Respiratory Care Unit | Sleep | 1996 | 208 |
| 25 | Identification and Modification of Environmental Noise in an ICU Setting | Chest | 1998 | 207 |
| 26 | Mitochondrial DNA Damage as a Mechanism of Cell Loss in Alzheimer's Disease | Laboratory Investigation | 2000 | 205 |
| 27 | Normalization of Memory Performance and Positive Airway Pressure Adherence in Memory-Impaired Patients With Obstructive Sleep Apnea | Chest | 2006 | 196 |
| 28 | Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice | Cardiovascular Research | 2016 | 196 |
| 29 | Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy | American Journal of Physiology - Renal Physiology | 2009 | 188 |
| 30 | The genetics of hyperuricaemia and gout | Nature Reviews Rheumatology | 2012 | 188 |
| 31 | Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease | Journal of the American College of Cardiology | 1999 | 181 |
| 32 | Complications of therapeutic plasma exchange: A prospective study of 1,727 procedures | Journal of Clinical Apheresis | 2007 | 181 |
| 33 | Acetylation-Dependent Signal Transduction for Type I Interferon Receptor | Cell | 2007 | 175 |
| 34 | Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan | Nature Communications | 2019 | 171 |
| 35 | Antimicrobial central venous catheters in adults: a systematic review and meta-analysis | Lancet Infectious Diseases, The | 2008 | 166 |
| 36 | Listeria monocytogenes:Clinical and Experimental Update | Journal of Infectious Diseases | 2002 | 160 |
| 37 | Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis. | Circulation | 1988 | 159 |
| 38 | Alcohol, Helping Young Adults to Have Unprotected Sex with Casual Partners: Findings from a Daily Diary Study of Alcohol Use and Sexual Behavior | Journal of Adolescent Health | 2009 | 159 |
| 39 | Aspartyl-asparagyl β hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms | Hepatology | 2006 | 157 |
| 40 | MEDICAL CONSEQUENCES OF SUBSTANCE ABUSE | Psychiatric Clinics of North America | 1999 | 154 |
| 41 | Gallbladder contraction in patients with pigment and cholesterol stones | Gastroenterology | 1989 | 153 |
| 42 | Community-Acquired Methicillin-Resistant Staphylococcus aureus in Southern New England Children | Pediatrics | 2004 | 153 |
| 43 | Percutaneous Image-guided Thermal Ablation and Radiation Therapy: Outcomes of Combined Treatment for 41 Patients with Inoperable Stage I/II Non–Small-Cell Lung Cancer | Journal of Vascular and Interventional Radiology | 2006 | 152 |
| 44 | Histone Deacetylase: A Potential Therapeutic Target for Fibrotic Disorders | Journal of Pharmacology and Experimental Therapeutics | 2010 | 152 |
| 45 | Hepatitis C disease among injection drug users: knowledge, perceived risk and willingness to receive treatment | Drug and Alcohol Dependence | 2001 | 151 |
| 46 | Epidemiology and survival outcomes of ocular and mucosal melanomas: A population‐based analysis | International Journal of Cancer | 2014 | 148 |
| 47 | Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression | Journal of the American Society of Nephrology: JASN | 2016 | 148 |
| 48 | The Thermal Resistance of Mycobacterium Paratuberculosis in Raw Milk under Conditions Simulating Pasteurization | Journal of Veterinary Diagnostic Investigation | 1993 | 146 |
| 49 | The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides* | Endocrine Reviews | 1999 | 144 |
| 50 | Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and immunosensitization to apoptosis and inhibition of metastases | Nitric Oxide - Biology and Chemistry | 2008 | 142 |
