| # | Title | Journal | Year | Citations |
|---|
| 1 | Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960 | Nature | 2008 | 489 |
| 2 | Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology | PLoS ONE | 2014 | 394 |
| 3 | Circulating interleukin-6 predicts survival in patients with metastatic breast cancer | International Journal of Cancer | 2003 | 365 |
| 4 | The Isolation of Nucleic Acids from Fixed, Paraffin-Embedded Tissues–Which Methods Are Useful When? | PLoS ONE | 2007 | 322 |
| 5 | Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections | Journal of the American College of Cardiology | 2015 | 238 |
| 6 | Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil: I. Natural history of tungiasis in man | Parasitology Research | 2003 | 216 |
| 7 | Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia | British Journal of Cancer | 2004 | 184 |
| 8 | Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling | Gut | 2013 | 155 |
| 9 | Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression | British Journal of Cancer | 2003 | 151 |
| 10 | New concepts in understanding evolution of desmoid tumors: MR imaging of 30 lesions | European Radiology | 1997 | 147 |
| 11 | Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis | Hepatology | 2014 | 141 |
| 12 | Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells | Leukemia | 2007 | 124 |
| 13 | The Presence of a Fibrotic Focus in Invasive Breast Carcinoma Correlates with the Expression of Carbonic Anhydrase IX and is a Marker of Hypoxia and Poor Prognosis | Breast Cancer Research and Treatment | 2003 | 120 |
| 14 | Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 112 |
| 15 | The influence of a pneumoperitoneum on the peritoneal implantation of free intraperitoneal colon cancer cells | Surgical Endoscopy and Other Interventional Techniques | 1996 | 108 |
| 16 | Dense-Core Senile Plaques in the Flemish Variant of Alzheimer's Disease Are Vasocentric | American Journal of Pathology | 2002 | 108 |
| 17 | Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model | Clinical and Experimental Metastasis | 2006 | 103 |
| 18 | Early distant relapse in ?node-negative? breast cancer patients is not predicted by occult axillary lymph node metastases, but by the features of the primary tumour | Journal of Pathology | 2001 | 102 |
| 19 | Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution | Nature Metabolism | 2019 | 102 |
| 20 | Isolation of Markers for Chondro-osteogenic Differentiation Using cDNA Library Subtraction | Journal of Biological Chemistry | 1996 | 94 |
| 21 | Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections | Genetics in Medicine | 2017 | 94 |
| 22 | Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID‐19): autopsy reveals a ferroptosis signature | ESC Heart Failure | 2020 | 93 |
| 23 | Detection of estrogen DNA-adducts in human breast tumor tissue and healthy tissue by combined nano LC-nano ES tandem mass spectrometry | Journal of the American Society for Mass Spectrometry | 2003 | 90 |
| 24 | Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties | FASEB Journal | 2005 | 89 |
| 25 | Multiple primary malignancies in osteosarcoma patients. Incidence and predictive value of osteosarcoma subtype for cancer syndromes related with osteosarcoma | European Journal of Human Genetics | 2003 | 87 |
| 26 | Mapping of serotonin 5-HT4 receptor mRNA and ligand binding sites in the post-mortem human brain | | 2000 | 86 |
| 27 | Differential secretome analysis of cancer‐associated fibroblasts and bone marrow‐derived precursors to identify microenvironmental regulators of colon cancer progression | Proteomics | 2013 | 85 |
| 28 | Comparison of pap smear, visual inspection with acetic acid, human papillomavirus DNA-PCR testing and cervicography | International Journal of Gynecology and Obstetrics | 2005 | 79 |
| 29 | Immunoreactivity for p53 protein in malignant mesothelioma and non-neoplastic mesothelium | Journal of Pathology | 1992 | 73 |
| 30 | Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil: IV. Clinical and histopathology | Parasitology Research | 2004 | 73 |
| 31 | P16INK4a as an adjunct marker in liquid-based cervical cytology | International Journal of Cancer | 2004 | 69 |
| 32 | Long-term acquired everolimus resistance in pancreatic neuroendocrine tumours can be overcome with novel PI3K-AKT-mTOR inhibitors | British Journal of Cancer | 2016 | 69 |
| 33 | Muscle fat content is strongly associated with NASH: A longitudinal study in patients with morbid obesity | Journal of Hepatology | 2021 | 68 |
| 34 | Foam cell replication and smooth muscle cell apoptosis in human saphenous vein grafts | Histopathology | 1994 | 67 |
| 35 | Chronic Exposure to the Carcinogenic Compound Benzo[a]Pyrene Induces Larger and Phenotypically Different Atherosclerotic Plaques in ApoE-Knockout Mice | American Journal of Pathology | 2004 | 67 |
| 36 | Autoimmune Gastropathy in Type 1 Diabetic Patients With Parietal Cell Antibodies: Histological and clinical findings | Diabetes Care | 2003 | 63 |
| 37 | Placental Malaria and Perinatal Transmission of Human Immunodeficiency Virus Type 1 | Journal of Infectious Diseases | 2003 | 62 |
| 38 | Expression and Nuclear Location of the Transcriptional Repressor Kaiso Is Regulated by the Tumor Microenvironment | Cancer Research | 2005 | 61 |
| 39 | Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: Beneficial effects on tumor growth, angiogenesis, bone disease and survival | International Journal of Cancer | 2007 | 57 |
| 40 | A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population | Obesity | 2013 | 57 |
| 41 | Detection and prognostic significance of circulating tumour cells in patients with metastatic breast cancer according to immunohistochemical subtypes | British Journal of Cancer | 2014 | 57 |
| 42 | Bovine papillomavirus DNA can be detected in keratinocytes of equine sarcoid tumors | Veterinary Microbiology | 2010 | 48 |
| 43 | Morphometric analysis of the uvula in patients with sleep-related breathing disorders | European Archives of Oto-Rhino-Laryngology | 2000 | 45 |
| 44 | Low-grade chondrosarcoma vs enchondroma: challenges in diagnosis and management | European Radiology | 2001 | 45 |
| 45 | Multifunctional Role of Matrix Metalloproteinases in Multiple Myeloma | American Journal of Pathology | 2004 | 44 |
| 46 | Immunocytochemistry in liquid-based cervical cytology: Analysis of clinical use following a cross-sectional study | International Journal of Cancer | 2006 | 44 |
| 47 | LacdiNAc- and LacNAc-containing glycans induce granulomas in an in vivo model for schistosome egg-induced hepatic granuloma formation | Glycobiology | 2006 | 44 |
| 48 | Incidence and Survival Trends of Uncommon Corpus Uteri Malignancies in the Netherlands, 1989–2008 | International Journal of Gynecological Cancer | 2012 | 41 |
| 49 | Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesothelium | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 1994 | 40 |
| 50 | Can cervical cancer screening be stopped at 50? The prevalence of HPV in elderly women | International Journal of Cancer | 2004 | 39 |
