# | Title | Journal | Year | Citations |
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1 | Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine | Nature Neuroscience | 2005 | 576 |
2 | Arousal effect of orexin A depends on activation of the histaminergic system | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 514 |
3 | Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis | Chemical Reviews | 2011 | 410 |
4 | A toxic monomeric conformer of the polyglutamine protein | Nature Structural and Molecular Biology | 2007 | 296 |
5 | Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase | BBA - Proteins and Proteomics | 2000 | 290 |
6 | Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens | Journal of Neuroscience | 2011 | 267 |
7 | Prostaglandin D synthase: Structure and function | Vitamins and Hormones | 2000 | 261 |
8 | miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression | Nature Neuroscience | 2011 | 252 |
9 | Circadian Dynamics of Cytosolic and Nuclear Ca2+ in Single Suprachiasmatic Nucleus Neurons | Neuron | 2003 | 250 |
10 | Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase | Cell | 1997 | 244 |
11 | Dopaminergic D1and D2Receptors Are Essential for the Arousal Effect of Modafinil | Journal of Neuroscience | 2008 | 220 |
12 | Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice | Journal of Immunology | 2002 | 212 |
13 | Prostaglandins and adenosine in the regulation of sleep and wakefulness | Current Opinion in Pharmacology | 2007 | 206 |
14 | Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms | Immunity | 2011 | 199 |
15 | Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor | Journal of Immunology | 2006 | 188 |
16 | Prostaglandin D2 and sleep/wake regulation | Sleep Medicine Reviews | 2011 | 176 |
17 | The Role of Adenosine in the Regulation of Sleep | Current Topics in Medicinal Chemistry | 2011 | 175 |
18 | Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 171 |
19 | Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence | Prostaglandins and Other Lipid Mediators | 2002 | 169 |
20 | An adenosine A2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats | Journal of Neurochemistry | 2005 | 139 |
21 | Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 139 |
22 | Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasion | European Journal of Immunology | 2003 | 137 |
23 | Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 137 |
24 | Prostaglandin D2 and sleep regulation | Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids | 1999 | 134 |
25 | Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. | Proceedings of the National Academy of Sciences of the United States of America | 1994 | 131 |
26 | Identification of a Fertility-Associated Protein in Bull Seminal Plasma As Lipocalin-Type Prostaglandin D Synthase1 | Biology of Reproduction | 1998 | 130 |
27 | Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A 1 receptors and promotes non-rapid eye movement sleep | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 129 |
28 | Cellular localization of lipocalin-type prostaglandin D synthase (?-trace) in the central nervous system of the adult rat | Journal of Comparative Neurology | 2000 | 128 |
29 | A Key Role for Old Yellow Enzyme in the Metabolism of Drugs by Trypanosoma cruzi | Journal of Experimental Medicine | 2002 | 125 |
30 | A metacaspase ofTrypanosoma bruceicauses loss of respiration competence and clonal death in the yeastSaccharomyces cerevisiae | FEBS Letters | 2002 | 125 |
31 | How do the basal ganglia regulate sleep–wake behavior? | Trends in Neurosciences | 2012 | 124 |
32 | Minireview: Sleep regulation in adenosine A 2A receptor-deficient mice | Neurology | 2003 | 123 |
33 | Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 112 |
34 | Region-dependent difference in the sleep-promoting potency of an adenosine A2Areceptor agonist | European Journal of Neuroscience | 1999 | 111 |
35 | Identification of a Novel Prostaglandin F2α Synthase in Trypanosoma brucei | Journal of Experimental Medicine | 2000 | 111 |
36 | An Apoptotic Depletion of Oligodendrocytes in the Twitcher, a Murine Model of Globoid Cell Leukodystrophy | Journal of Neuropathology and Experimental Neurology | 1999 | 102 |
37 | CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats | Brain Research | 1997 | 101 |
38 | Prostaglandin D, E, and F synthases | Journal of Lipid Mediators and Cell Signalling | 1995 | 96 |
39 | Involvement of adenosine A2A receptor in sleep promotion | European Journal of Pharmacology | 1998 | 95 |
40 | Lipocalin-Type Prostaglandin D Synthase in Human Male Reproductive Organs and Seminal Plasma1 | Biology of Reproduction | 1998 | 93 |
41 | Structural and Functional Characterization of HQL-79, an Orally Selective Inhibitor of Human Hematopoietic Prostaglandin D Synthase | Journal of Biological Chemistry | 2006 | 91 |
42 | Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase | FEBS Journal | 2000 | 89 |
43 | Anti-inflammatory role of PGD 2 in acute lung inflammation and therapeutic application of its signal enhancement | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 88 |
44 | Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain | Neurochemical Research | 2000 | 87 |
45 | Role of prostaglandin D 2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 86 |
46 | Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells | ELife | 2014 | 86 |
47 | Algorithm for sleep scoring in experimental animals based on fast Fourier transform power spectrum analysis of the electroencephalogram | Sleep and Biological Rhythms | 2008 | 83 |
48 | Prostaglandin F2 Synthase Activities of Aldo-Keto Reductase 1B1, 1B3 and 1B7 | Journal of Biochemistry | 2008 | 82 |
49 | Plasmodium falciparum Produces Prostaglandins that are Pyrogenic, Somnogenic, and Immunosuppressive Substances in Humans | Journal of Experimental Medicine | 1998 | 80 |
50 | Hematopoietic Prostaglandin D Synthase and DP1 Receptor Are Selectively Upregulated in Microglia and Astrocytes Within Senile Plaques From Human Patients and in a Mouse Model of Alzheimer Disease | Journal of Neuropathology and Experimental Neurology | 2007 | 78 |