# | Title | Journal | Year | Citations |
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1 | Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin | Nature | 1997 | 3,053 |
2 | Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines | Science | 1983 | 959 |
3 | Separation of cells by velocity sedimentation | Journal of Cellular Physiology | 1969 | 941 |
4 | Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span | Current Biology | 1998 | 939 |
5 | Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies | Nature | 1985 | 899 |
6 | Stem cell gene expression programs influence clinical outcome in human leukemia | Nature Medicine | 2011 | 894 |
7 | The physics, biophysics and technology of photodynamic therapy | Physics in Medicine and Biology | 2008 | 849 |
8 | Regulation of PTEN Transcription by p53 | Molecular Cell | 2001 | 815 |
9 | Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines | Nature | 1985 | 801 |
10 | Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice | Immunity | 1997 | 778 |
11 | Consistent blind protein structure generation from NMR chemical shift data | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 776 |
12 | Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 | Nature | 2002 | 766 |
13 | Exploring the role of cancer stem cells in radioresistance | Nature Reviews Cancer | 2008 | 766 |
14 | Calcium-induced conformational transition revealed by the solution structure of apo calmodulin | Nature Structural and Molecular Biology | 1995 | 690 |
15 | The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development | Cell | 2000 | 674 |
16 | Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation | Cell | 2003 | 657 |
17 | Progesterone induces adult mammary stem cell expansion | Nature | 2010 | 608 |
18 | Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation | Blood | 2011 | 556 |
19 | Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK | Nature Immunology | 2008 | 555 |
20 | Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation | Biochemical Journal | 1994 | 554 |
21 | Two Types of Ribosome in Mouse–Hamster Hybrid Cells | Nature: New Biology | 1971 | 534 |
22 | T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance | Immunity | 2001 | 524 |
23 | Suppression of tumor growth and metastasis in Mgat5-deficient mice | Nature Medicine | 2000 | 511 |
24 | Calmodulin target database | Journal of Structural and Functional Genomics | 2000 | 500 |
25 | Molecular mechanics of calcium–myristoyl switches | Nature | 1997 | 492 |
26 | The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses | Nature Immunology | 2003 | 479 |
27 | Positive and negative thymocyte selection induced by different concentrations of a single peptide | Science | 1994 | 475 |
28 | Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development | Immunity | 2000 | 472 |
29 | The role of cytokines in classical Hodgkin lymphoma | Blood | 2002 | 453 |
30 | P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma | New England Journal of Medicine | 1991 | 430 |
31 | Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice | Genes and Development | 2000 | 429 |
32 | Detergents for the stabilization and crystallization of membrane proteins | Methods | 2007 | 426 |
33 | Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity | Genes and Development | 2003 | 412 |
34 | Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 | Nature | 2008 | 408 |
35 | Solution structure of the epithelial cadherin domain responsible for selective cell adhesion | Science | 1995 | 407 |
36 | Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation | Immunity | 1997 | 402 |
37 | DNA-damage repair; the good, the bad, and the ugly | EMBO Journal | 2008 | 396 |
38 | Physical separation of hemopoietic stem cells from cells forming colonies in culture | Journal of Cellular Physiology | 1969 | 392 |
39 | The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein | Biochemical and Biophysical Research Communications | 1986 | 389 |
40 | Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 371 |
41 | Blood-vessel closure using photosensitizers engineered for two-photon excitation | Nature Photonics | 2008 | 355 |
42 | Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner | Molecular and Cellular Biology | 2002 | 354 |
43 | ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase | EMBO Journal | 1997 | 343 |
44 | Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription | EMBO Journal | 2000 | 339 |
45 | Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state | Nature | 1995 | 335 |
46 | Spleen-Colony Formation in Anemic Mice of Genotype WW | Science | 1964 | 333 |
47 | Structure of the p53 Binding Domain of HAUSP/USP7 Bound to Epstein-Barr Nuclear Antigen 1 | Molecular Cell | 2005 | 317 |
48 | Prostate cancer detection with multi‐parametric MRI: Logistic regression analysis of quantitative T2, diffusion‐weighted imaging, and dynamic contrast‐enhanced MRI | Journal of Magnetic Resonance Imaging | 2009 | 311 |
49 | Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo | Journal of Experimental Medicine | 2000 | 309 |
50 | Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand | Nature | 2002 | 309 |