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Top Articles

#TitleJournalYearCitations
1Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulinNature19973,053
2Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell linesScience1983959
3Separation of cells by velocity sedimentationJournal of Cellular Physiology1969941
4Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life spanCurrent Biology1998939
5Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodiesNature1985899
6Stem cell gene expression programs influence clinical outcome in human leukemiaNature Medicine2011894
7The physics, biophysics and technology of photodynamic therapyPhysics in Medicine and Biology2008849
8Regulation of PTEN Transcription by p53Molecular Cell2001815
9Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell linesNature1985801
10Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient MiceImmunity1997778
11Consistent blind protein structure generation from NMR chemical shift dataProceedings of the National Academy of Sciences of the United States of America2008776
12Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4Nature2002766
13Exploring the role of cancer stem cells in radioresistanceNature Reviews Cancer2008766
14Calcium-induced conformational transition revealed by the solution structure of apo calmodulinNature Structural and Molecular Biology1995690
15The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland DevelopmentCell2000674
16Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 DegradationCell2003657
17Progesterone induces adult mammary stem cell expansionNature2010608
18Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylationBlood2011556
19Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIKNature Immunology2008555
20Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylationBiochemical Journal1994554
21Two Types of Ribosome in Mouse–Hamster Hybrid CellsNature: New Biology1971534
22T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral ToleranceImmunity2001524
23Suppression of tumor growth and metastasis in Mgat5-deficient miceNature Medicine2000511
24Calmodulin target databaseJournal of Structural and Functional Genomics2000500
25Molecular mechanics of calcium–myristoyl switchesNature1997492
26The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responsesNature Immunology2003479
27Positive and negative thymocyte selection induced by different concentrations of a single peptideScience1994475
28Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic DevelopmentImmunity2000472
29The role of cytokines in classical Hodgkin lymphomaBlood2002453
30P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for NeuroblastomaNew England Journal of Medicine1991430
31Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient miceGenes and Development2000429
32Detergents for the stabilization and crystallization of membrane proteinsMethods2007426
33Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunityGenes and Development2003412
34Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1Nature2008408
35Solution structure of the epithelial cadherin domain responsible for selective cell adhesionScience1995407
36Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus CostimulationImmunity1997402
37DNA-damage repair; the good, the bad, and the uglyEMBO Journal2008396
38Physical separation of hemopoietic stem cells from cells forming colonies in cultureJournal of Cellular Physiology1969392
39The mdrl gene, responsible for multidrug-resistance, codes for P-glycoproteinBiochemical and Biophysical Research Communications1986389
40Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.Proceedings of the National Academy of Sciences of the United States of America1990371
41Blood-vessel closure using photosensitizers engineered for two-photon excitationNature Photonics2008355
42Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent MannerMolecular and Cellular Biology2002354
43ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymeraseEMBO Journal1997343
44Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcriptionEMBO Journal2000339
45Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free stateNature1995335
46Spleen-Colony Formation in Anemic Mice of Genotype WWScience1964333
47Structure of the p53 Binding Domain of HAUSP/USP7 Bound to Epstein-Barr Nuclear Antigen 1Molecular Cell2005317
48Prostate cancer detection with multi‐parametric MRI: Logistic regression analysis of quantitative T2, diffusion‐weighted imaging, and dynamic contrast‐enhanced MRIJournal of Magnetic Resonance Imaging2009311
49Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in VivoJournal of Experimental Medicine2000309
50Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligandNature2002309