| # | Title | Journal | Year | Citations |
|---|
| 1 | Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat | Journal of Neuroscience Methods | 1985 | 4,817 |
| 2 | INFLUENCE OF PLAQUE CONFIGURATION AND STRESS DISTRIBUTION ON FISSURING OF CORONARY ATHEROSCLEROTIC PLAQUES | Lancet, The | 1989 | 1,113 |
| 3 | The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs | Journal of Neuroscience Methods | 1980 | 783 |
| 4 | Something from “Nothing” − Eight Weak Estrogenic Chemicals Combined at Concentrations below NOECs Produce Significant Mixture Effects | Environmental Science & Technology | 2002 | 778 |
| 5 | Quinone chemistry and toxicity | Toxicology and Applied Pharmacology | 1992 | 697 |
| 6 | Inward current channels activated by intracellular Ca in cultured cardiac cells | Nature | 1981 | 694 |
| 7 | CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY? | British Journal of Pharmacology | 1978 | 692 |
| 8 | Atherosclerotic plaque caps are locally weakened when macrophages density is increased | Atherosclerosis | 1991 | 513 |
| 9 | Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin | Nature | 1987 | 454 |
| 10 | The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro | Neuroscience | 1987 | 369 |
| 11 | Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788 | Psychopharmacology | 1986 | 311 |
| 12 | Evidence for the existence of a raphe projection to the substantia nigra in rat | Brain Research | 1976 | 283 |
| 13 | Redox cycling and sulphydryl arylation; Their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes | Chemico-Biological Interactions | 1988 | 276 |
| 14 | The anxiogenic action of benzodiazepine antagonists | Neuropharmacology | 1982 | 266 |
| 15 | Oxidants, inflammation, and anti‐inflammatory drugs | FASEB Journal | 1988 | 246 |
| 16 | SELECTIVE DEPRESSION OF SYNAPTIC EXCITATION IN CAT SPINAL NEURONES BY BACLOFEN: AN IONTOPHORETIC STUDY | British Journal of Pharmacology | 1981 | 242 |
| 17 | Ivy Cells: A Population of Nitric-Oxide-Producing, Slow-Spiking GABAergic Neurons and Their Involvement in Hippocampal Network Activity | Neuron | 2008 | 221 |
| 18 | Neocortical layer 6, a review | Frontiers in Neuroanatomy | 2010 | 218 |
| 19 | Synaptic mechanisms in the substantia nigra | Journal of Pharmacy and Pharmacology | 2011 | 209 |
| 20 | The dorsal and medial raphe projections to the substantia nigra in the rat: Electrophysiological, biochemical and behavioural observations | Brain Research | 1978 | 206 |
| 21 | ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS | British Journal of Pharmacology | 1980 | 203 |
| 22 | Dextromethorphan and neuromodulation: old drug coughs up new activities | Trends in Pharmacological Sciences | 1989 | 201 |
| 23 | Inhibition of Peroxynitrite Dependent Tyrosine Nitration by Hydroxycinnamates | Free Radical Biology and Medicine | 1998 | 195 |
| 24 | Axonal GABA-receptors in mammalian peripheral nerve trunks | Brain Research | 1978 | 184 |
| 25 | The Importance of Stereochemistry in the Clinical Pharmacokinetics of the 2-Arylpropionic Acid Non-Steroidal Anti-Inflammatory Drugs | Clinical Pharmacokinetics | 1984 | 180 |
| 26 | M-currents in voltage-clamped mammalian sympathetic neurones | Neuroscience Letters | 1981 | 179 |
| 27 | Complex changes of GABAA and GABAB receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy | Brain Research | 1995 | 178 |
| 28 | Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo | Biochemical Journal | 1972 | 175 |
| 29 | Mixtures of four organochlorines enhance human breast cancer cell proliferation. | Environmental Health Perspectives | 2001 | 171 |
| 30 | Aldose reductase inhibitors and their potential for the treatment of diabetic complications | Trends in Pharmacological Sciences | 1994 | 170 |
| 31 | Prediction and assessment of the effects of mixtures of four xenoestrogens. | Environmental Health Perspectives | 2000 | 170 |
| 32 | 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current | Neuroscience Letters | 1986 | 169 |
| 33 | INVESTIGATION OF THE VASODILATOR AND ANTISECRETORY ROLE OF PROSTAGLANDINS IN THE RAT GASTRIC MUCOSA BY USE OF NON‐STEROIDAL ANTI‐INFLAMMATORY DRUGS | British Journal of Pharmacology | 1975 | 165 |
| 34 | Selective inhibition of neuronal GABA uptake by cis-1,3-aminocyclohexane carboxylic acid | Nature | 1976 | 165 |
| 35 | Synaptosomal membrane lipids of mice during continuous exposure to ethanol | Journal of Pharmacy and Pharmacology | 2011 | 165 |
| 36 | Evidence for a GABAergic nigrothalamic pathway in the rat | Experimental Brain Research | 1980 | 164 |
| 37 | Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses | Nature Neuroscience | 2011 | 154 |
| 38 | Studies on the role of ACTH and of 5-HT in anxiety, using an animal model | Journal of Pharmacy and Pharmacology | 2011 | 152 |
| 39 | The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat | British Journal of Pharmacology | 1973 | 151 |
| 40 | Insulin and insulin-like growth factor I enhance regeneration in cultured adult rat sensory neurones | Brain Research | 1993 | 151 |
| 41 | Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis | Journal of Neuroscience | 2009 | 151 |
| 42 | Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat | Journal of Pharmacy and Pharmacology | 2011 | 148 |
| 43 | HYPERPOLARIZING ‘α2’‐ADRENOCEPTORS IN RAT SYMPATHETIC GANGLIA | British Journal of Pharmacology | 1979 | 145 |
| 44 | The 5-HT3 receptor ligand, [3H]BRL 43694, binds to presynaptic sites in the nucleus tractus solitarius of the rat | Neuropharmacology | 1989 | 145 |
| 45 | Effects of membrane cholesterol on the sensitivity of the GABAA receptor to GABA in acutely dissociated rat hippocampal neurones | Neuropharmacology | 2001 | 145 |
| 46 | A Hypothesis for the Mode of Action of α-Methyldopa in Relieving Hypertension | Journal of Pharmacy and Pharmacology | 2011 | 141 |
| 47 | Transient calcium‐dependent potassium current in magnocellular neurosecretory cells of the rat supraoptic nucleus. | Journal of Physiology | 1988 | 137 |
| 48 | Multiple sites of action for anxiogenic drugs: Behavioural, electrophysiological and biochemical correlations | Psychopharmacology | 1984 | 136 |
| 49 | Functional innervation of cultured hippocampal neurones by cholinergic afferents from co-cultured septal explants | Nature | 1985 | 136 |
| 50 | Diabetic neuropathy, nerve growth factor and other neurotrophic factors | Trends in Neurosciences | 1994 | 134 |
