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Top Articles

#TitleJournalYearCitations
1Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy20211,430
2Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancerMolecular Cancer2014840
3Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytesClinical Science2015263
4Increased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke PatientsPLoS ONE2016184
5NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertensionCell Death and Disease2017179
6FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesityBiochimica Et Biophysica Acta - Molecular Basis of Disease2015168
7Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damageNeuropharmacology2008128
8Chronic fluoxetine treatment improves ischemia‐induced spatial cognitive deficits through increasing hippocampal neurogenesis after strokeJournal of Neuroscience Research2009116
9FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in MiceDiabetes2016114
10BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor GrowthClinical Cancer Research2015106
11FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesityMetabolism: Clinical and Experimental2018105
12Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult ratsJournal of Biomedical Research2013102
13Dvl2-Dependent Activation of Daam1 and RhoA Regulates Wnt5a-Induced Breast Cancer Cell MigrationPLoS ONE201297
14Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathwaysCell Death and Disease201596
15Salusin-β Promotes Vascular Smooth Muscle Cell Migration and Intimal Hyperplasia After Vascular InjuryviaROS/NFκB/MMP-9 PathwayAntioxidants and Redox Signaling201694
16Lysophosphatidic Acid Induces MDA-MB-231 Breast Cancer Cells Migration through Activation of PI3K/PAK1/ERK SignalingPLoS ONE201090
17TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in miceCell Death and Disease201990
18MiR155‐5p in adventitial fibroblasts‐derived extracellular vesicles inhibits vascular smooth muscle cell proliferation via suppressing angiotensin‐converting enzyme expressionJournal of Extracellular Vesicles202089
19NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular RemodelingCellular Physiology and Biochemistry201788
20DHEA prevents Aβ25–35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signalingNeuropharmacology201082
21PI3K/Akt-dependent phosphorylation of GSK3β and activation of RhoA regulate Wnt5a-induced gastric cancer cell migrationCellular Signalling201381
22Angiotensin-(1–7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathwaysScientific Reports201681
23Long non-coding RNA NONHSAT101069 promotes epirubicin resistance, migration, and invasion of breast cancer cells through NONHSAT101069/miR-129-5p/Twist1 axisOncogene201981
24Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in ratsActa Physiologica201180
25ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failureJournal of Applied Physiology200478
26Enhanced Adipose Afferent Reflex Contributes to Sympathetic Activation in Diet-Induced Obesity HypertensionHypertension201278
27Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin–angiotensin system and proinflammatory cytokines in hypertensionToxicology and Applied Pharmacology201478
28Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognitionNature Communications202178
29Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and miceScientific Reports201577
30Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male miceHippocampus201076
31β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetesScientific Reports201673
32Abnormal synaptic plasticity in basolateral amygdala may account for hyperactivity and attention-deficit in male rat exposed perinatally to low-dose bisphenol-ANeuropharmacology201172
33Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in MiceMolecular Neurobiology201672
34MICAL1 facilitates breast cancer cell proliferation via ROS‐sensitive ERK/cyclin D pathwayJournal of Cellular and Molecular Medicine201869
35Negative regulation of neurogenesis and spatial memory by NR2B‐containing NMDA receptorsJournal of Neurochemistry200867
36MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cellsBMC Cancer201667
37Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathyCell Death and Disease201767
38Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in ratsExperimental Physiology200864
39Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertensionActa Physiologica201564
40Angiotensin AT1receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive ratsExperimental Physiology201163
41Artificial microRNA interference targeting AT1a receptors in paraventricular nucleus attenuates hypertension in ratsGene Therapy201263
42Anti-amnesic effect of neurosteroid PREGS in Aβ25–35-injected mice through σ1 receptor- and α7nAChR-mediated neuroprotectionNeuropharmacology201263
43Salusin-β contributes to vascular remodeling associated with hypertension via promoting vascular smooth muscle cell proliferation and vascular fibrosisBiochimica Et Biophysica Acta - Molecular Basis of Disease201563
44Sex differences in the adult HPA axis and affective behaviors are altered by perinatal exposure to a low dose of bisphenol ABrain Research201461
45Angiotensin-(1–7) in the Rostral Ventrolateral Medulla Modulates Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activation in Renovascular Hypertensive RatsHypertension201360
46Simvastatin prevents β-amyloid25–35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphateNeuropharmacology201560
47Exposure of preimplantation embryos to low-dose bisphenol A impairs testes development and suppresses histone acetylation of StAR promoter to reduce production of testosterone in miceMolecular and Cellular Endocrinology201660
48Neurosteroid estradiol rescues ischemia-induced deficit in the long-term potentiation of rat hippocampal CA1 neuronsNeuropharmacology200759
49Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expressionJournal of Neuroinflammation201559
50DHEA-Neuroprotection and -Neurotoxicity after Transient Cerebral Ischemia in RatsJournal of Cerebral Blood Flow and Metabolism200958