| # | Title | Journal | Year | Citations |
|---|
| 1 | Immune response in mice that lack the interferon-gamma receptor | Science | 1993 | 1,569 |
| 2 | Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences | Cell | 2014 | 1,493 |
| 3 | Requirement for transcription factor IRF-1 in NO synthase induction in macrophages | Science | 1994 | 814 |
| 4 | Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions | Journal of Biological Chemistry | 1991 | 606 |
| 5 | Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite | Science | 1980 | 471 |
| 6 | Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon | Science | 1982 | 450 |
| 7 | IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice | Journal of Immunology | 1989 | 424 |
| 8 | IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. | Journal of Immunology | 1989 | 410 |
| 9 | Stenotrophomonas, a New Bacterial Genus for Xanthomonas maltophilia (Hugh 1980) Swings et al. 1983 | International Journal of Systematic Bacteriology | 1993 | 406 |
| 10 | Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. | Journal of Experimental Medicine | 1993 | 359 |
| 11 | Chemokine Receptors: Keys to AIDS Pathogenesis? | Cell | 1998 | 318 |
| 12 | Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence. | Molecular and Cellular Biology | 1990 | 279 |
| 13 | A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. | Journal of Cell Biology | 1992 | 278 |
| 14 | Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 276 |
| 15 | Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 269 |
| 16 | Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4 | Nature | 1993 | 265 |
| 17 | DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope | Science | 1984 | 257 |
| 18 | Toxicity and anaerobic biodegradability of substituted phenols under methanogenic conditions | Environmental Toxicology and Chemistry | 1989 | 247 |
| 19 | Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP. | Journal of Biological Chemistry | 1988 | 238 |
| 20 | Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes. | EMBO Journal | 1992 | 233 |
| 21 | The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages | Molecular Microbiology | 2008 | 230 |
| 22 | Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A | Science | 1983 | 225 |
| 23 | Anaerobic degradation of toluene by a denitrifying bacterium | Applied and Environmental Microbiology | 1991 | 223 |
| 24 | Inhibition of rot translation by RNAIII, a key feature of agr function | Molecular Microbiology | 2006 | 213 |
| 25 | TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. | Journal of Immunology | 1993 | 213 |
| 26 | Structure of the plasmodium knowlesi gene coding for the circumsporozoite protein | Cell | 1983 | 210 |
| 27 | SinI modulates the activity of SinR, a developmental switch protein of Bacillus subtilis, by protein-protein interaction. | Genes and Development | 1993 | 198 |
| 28 | Activation of p38 Mitogen-Activated Protein Kinase by Sodium Salicylate Leads to Inhibition of Tumor Necrosis Factor-Induced IκBα Phosphorylation and Degradation | Molecular and Cellular Biology | 1998 | 196 |
| 29 | Prevalence of Methicillin‐Resistant and Methicillin‐SusceptibleStaphylococcus aureusin the Community | Journal of Infectious Diseases | 2000 | 196 |
| 30 | Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP | Journal of Biological Chemistry | 1988 | 192 |
| 31 | A Secreted Bacterial Protease Tailors the Staphylococcus aureus Virulence Repertoire to Modulate Bone Remodeling during Osteomyelitis | Cell Host and Microbe | 2013 | 188 |
| 32 | TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins | Journal of Immunology | 1993 | 179 |
| 33 | Effect of Mild Acid on Gene Expression in Staphylococcus aureus | Journal of Bacteriology | 2004 | 173 |
| 34 | Improved long term survival after intracavitary interleukin-2 and lymphokine-activated killer cells for adults with recurrent malignant glioma | Cancer | 1995 | 172 |
| 35 | TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo | Journal of Immunology | 1996 | 166 |
| 36 | Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts. | Molecular and Cellular Biology | 1990 | 165 |
| 37 | TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. | Journal of Immunology | 1996 | 164 |
| 38 | Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 160 |
| 39 | Antibodies to sporozoites: their frequent occurrence in individuals living in an area of hyperendemic malaria | Science | 1979 | 158 |
| 40 | Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet | Genome Medicine | 2016 | 153 |
| 41 | Degradation of toluene and m-xylene and transformation of o-xylene by denitrifying enrichment cultures | Applied and Environmental Microbiology | 1991 | 151 |
| 42 | Apoptosis induced by bacterial pathogens | Microbial Pathogenesis | 1994 | 144 |
| 43 | Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein | Journal of Neuroimmunology | 1992 | 137 |
| 44 | Reverse transcriptase-dependent synthesis of a covalently linked, branched DNA-RNA compound in E. coli B | Cell | 1989 | 135 |
| 45 | Long pentraxins: an emerging group of proteins with diverse functions | Cytokine and Growth Factor Reviews | 1996 | 133 |
| 46 | Chlorophenol degradation coupled to sulfate reduction | Applied and Environmental Microbiology | 1990 | 131 |
| 47 | Inducible System for the Utilization of β-Glucosides in Escherichia coli I. Active Transport and Utilization of β-Glucosides | Journal of Bacteriology | 1967 | 126 |
| 48 | Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response | Laboratory Investigation | 1989 | 126 |
| 49 | TSG-6: a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis. | Journal of Immunology | 1993 | 125 |
| 50 | The fate of lignin and lignin‐derived compounds in anaerobic environments | Geomicrobiology Journal | 1987 | 124 |
