| # | Title | Journal | Year | Citations |
|---|
| 1 | Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF | Science | 1999 | 2,020 |
| 2 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 3 | Production of the Alzheimer amyloid beta protein by normal proteolytic processing | Science | 1992 | 1,470 |
| 4 | SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 | Nature Cell Biology | 1999 | 1,405 |
| 5 | Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type | Science | 1990 | 1,323 |
| 6 | RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain | Nature Medicine | 2003 | 1,277 |
| 7 | Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation | Cancer Cell | 2011 | 1,105 |
| 8 | The SCF ubiquitin ligase: insights into a molecular machine | Nature Reviews Molecular Cell Biology | 2004 | 983 |
| 9 | Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups | Cancer Cell | 2015 | 933 |
| 10 | β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy | Nature Medicine | 1998 | 831 |
| 11 | Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells✪ | Journal of Experimental Medicine | 2001 | 823 |
| 12 | Systemic effects of local radiotherapy | Lancet Oncology, The | 2009 | 822 |
| 13 | Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid | Neuroscience Letters | 1992 | 787 |
| 14 | Immunology of the Maternal-Fetal Interface | Annual Review of Immunology | 2013 | 709 |
| 15 | New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs | Cell | 2016 | 702 |
| 16 | Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies | Journal of Virology | 2004 | 665 |
| 17 | Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153) | Molecular and Cellular Biology | 1996 | 635 |
| 18 | TRAP Is Necessary for Gliding Motility and Infectivity of Plasmodium Sporozoites | Cell | 1997 | 580 |
| 19 | Expression of hypoxia-inducible factor 1? in brain tumors | Cancer | 2000 | 570 |
| 20 | Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 506 |
| 21 | Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids | Cell | 2018 | 505 |
| 22 | Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor | Science | 1980 | 492 |
| 23 | Lymphoid Neoplasia Associated with the Acquired Immunodeficiency Syndrome (AIDS) | Annals of Internal Medicine | 1988 | 478 |
| 24 | Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite | Science | 1980 | 471 |
| 25 | Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation | Biochemical and Biophysical Research Communications | 1996 | 438 |
| 26 | Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 427 |
| 27 | γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia | Nature Medicine | 2009 | 417 |
| 28 | An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease | Nature | 1997 | 392 |
| 29 | Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction? | Blood | 2001 | 388 |
| 30 | Plasma membrane glycoprotein which mediates adhesion of fibroblasts to collagen | Nature | 1976 | 381 |
| 31 | Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria | Science | 1985 | 376 |
| 32 | Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers During Active Surveillance | JAMA Otolaryngology - Head and Neck Surgery | 2017 | 359 |
| 33 | Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro | American Journal of Pathology | 1994 | 357 |
| 34 | Fibronectin: A review of its structure and biological activity | Molecular and Cellular Biochemistry | 1980 | 351 |
| 35 | A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia | Nature | 2011 | 351 |
| 36 | The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of plasmodium falciparum sporozoites | Cell | 1992 | 349 |
| 37 | Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease | Journal of Neurochemistry | 1988 | 347 |
| 38 | Correlation between fibrinogen binding to human platelets and platelet aggregability | Blood | 1980 | 346 |
| 39 | Inhibition of development of exoerythrocytic forms of malaria parasites by gamma-interferon | Science | 1986 | 339 |
| 40 | Pathology with clinical correlations of primary central nervous system non-Hodgkin's lymphoma. The massachusetts general hospital experience 1958-1989 | Cancer | 1994 | 322 |
| 41 | Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes. | Journal of Experimental Medicine | 1993 | 317 |
| 42 | Diffusion-Weighted MRI for Quantification of Liver Fibrosis: Preliminary Experience | American Journal of Roentgenology | 2007 | 317 |
| 43 | Bax cleavage is mediated by calpain during drug-induced apoptosis | Oncogene | 1998 | 316 |
| 44 | miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis | Cancer Cell | 2011 | 314 |
| 45 | Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis | Lancet Oncology, The | 2013 | 307 |
| 46 | The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex | Biochemical Journal | 1993 | 303 |
| 47 | SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance | Nature | 2015 | 303 |
| 48 | Inhibition of Adenosine Diphosphate-Induced Secondary Aggregation and Other Platelet Functions by Acetylsalicylic Acid Ingestion | Experimental Biology and Medicine | 1968 | 300 |
| 49 | Modeling Patient-Derived Glioblastoma with Cerebral Organoids | Cell Reports | 2019 | 293 |
| 50 | T2–FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project | Clinical Cancer Research | 2017 | 285 |
