| # | Title | Journal | Year | Citations |
|---|
| 1 | Mutations in the p53 gene occur in diverse human tumour types | Nature | 1989 | 2,702 |
| 2 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 3 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 4 | Liver regeneration: molecular mechanisms of growth control | FASEB Journal | 1990 | 898 |
| 5 | The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function | Cell Metabolism | 2014 | 876 |
| 6 | The whole-genome landscape of medulloblastoma subtypes | Nature | 2017 | 787 |
| 7 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 8 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes | Nature | 2012 | 761 |
| 9 | Epidemiology of basal-like breast cancer | Breast Cancer Research and Treatment | 2008 | 747 |
| 10 | Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease | Hepatology | 2010 | 609 |
| 11 | Thresholds for thermal damage to normal tissues: An update | International Journal of Hyperthermia | 2011 | 541 |
| 12 | Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer | Cell | 2018 | 459 |
| 13 | Guidelines on the use of therapeutic apheresis in clinical practice—Evidence‐based approach from the apheresis applications committee of the American Society for Apheresis | Journal of Clinical Apheresis | 2010 | 441 |
| 14 | Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas | Cancer Cell | 2018 | 396 |
| 15 | Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells | Oncogene | 2009 | 394 |
| 16 | Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma | Nature Genetics | 2009 | 391 |
| 17 | Acidic stress promotes a glioma stem cell phenotype | Cell Death and Differentiation | 2011 | 358 |
| 18 | Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration | Hepatology | 1991 | 353 |
| 19 | Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis | Lancet Oncology, The | 2016 | 274 |
| 20 | Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease | Hepatology | 2014 | 256 |
| 21 | A novel human disease with abnormal prion protein sensitive to protease | Annals of Neurology | 2008 | 250 |
| 22 | Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 | Nature Medicine | 2017 | 240 |
| 23 | Activation and Cross-talk between Akt, NF-κB, and Unfolded Protein Response Signaling in 1-LN Prostate Cancer Cells Consequent to Ligation of Cell Surface-associated GRP78 | Journal of Biological Chemistry | 2006 | 236 |
| 24 | Biological Role and Therapeutic Potential of IDH Mutations in Cancer | Cancer Cell | 2018 | 234 |
| 25 | Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease | JAMA Network Open | 2019 | 230 |
| 26 | Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer | The Open Nanomedicine Journal | 2011 | 227 |
| 27 | Poor drug distribution as a possible explanation for the results of the PRECISE trial | Journal of Neurosurgery | 2010 | 219 |
| 28 | Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage | Science | 2018 | 217 |
| 29 | Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A | Journal of Biological Chemistry | 1995 | 214 |
| 30 | Disruption of a Nonribosomal Peptide Synthetase in Aspergillus fumigatus Eliminates Gliotoxin Production | Eukaryotic Cell | 2006 | 208 |
| 31 | The DNA methylation landscape of advanced prostate cancer | Nature Genetics | 2020 | 198 |
| 32 | Liver regeneration: molecular mechanisms of growth control | FASEB Journal | 1990 | 195 |
| 33 | Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone | Science Translational Medicine | 2016 | 178 |
| 34 | SMA–doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours | Journal of Controlled Release | 2004 | 173 |
| 35 | Leukaemia hijacks a neural mechanism to invade the central nervous system | Nature | 2018 | 173 |
| 36 | Safety profile of recombinant factor VIIa | Seminars in Hematology | 2004 | 170 |
| 37 | Thrombin Activates Factor XI on Activated Platelets in the Absence of Factor XII | Arteriosclerosis, Thrombosis, and Vascular Biology | 1999 | 169 |
| 38 | Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease | JAMA Neurology | 2014 | 166 |
| 39 | TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma | Acta Neuropathologica | 2013 | 146 |
| 40 | Signals from dying hepatocytes trigger growth of liver progenitors | Gut | 2010 | 143 |
| 41 | Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours | International Journal of Hyperthermia | 2010 | 136 |
| 42 | PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma | PLoS ONE | 2013 | 136 |
| 43 | Digital pathology and computational image analysis in nephropathology | Nature Reviews Nephrology | 2020 | 133 |
| 44 | A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease | Hepatology | 2016 | 128 |
| 45 | High-dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia-like conditions in a cell-based model system | British Journal of Haematology | 2001 | 126 |
| 46 | Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease | Liver International | 2013 | 123 |
| 47 | Implications for Human Leukocyte Antigen Antibodies After Lung Transplantation | Chest | 2013 | 121 |
| 48 | The expanded role of fatty acid metabolism in cancer: new aspects and targets | Precision Clinical Medicine | 2019 | 119 |
| 49 | Morphologic Features of ALK-negative Anaplastic Large Cell Lymphomas With DUSP22 Rearrangements | American Journal of Surgical Pathology | 2016 | 103 |
| 50 | Patient selection for prostate focal therapy in the era of active surveillance: an International Delphi Consensus Project | Prostate Cancer and Prostatic Diseases | 2017 | 103 |
