| # | Title | Journal | Year | Citations |
|---|
| 1 | A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment | Cell | 2000 | 3,071 |
| 2 | Principles of bioactive lipid signalling: lessons from sphingolipids | Nature Reviews Molecular Cell Biology | 2008 | 2,820 |
| 3 | US Trends in Prevalence, Awareness, Treatment, and Control of Hypertension, 1988-2008 | JAMA - Journal of the American Medical Association | 2010 | 1,689 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 5 | Diastolic Heart Failure — Abnormalities in Active Relaxation and Passive Stiffness of the Left Ventricle | New England Journal of Medicine | 2004 | 1,319 |
| 6 | Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy | Cancer Immunology, Immunotherapy | 2009 | 1,089 |
| 7 | New Concepts in Diastolic Dysfunction and Diastolic Heart Failure: Part I | Circulation | 2002 | 1,078 |
| 8 | The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria | Allergy: European Journal of Allergy and Clinical Immunology | 2018 | 1,008 |
| 9 | Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years | JAMA - Journal of the American Medical Association | 2016 | 991 |
| 10 | The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 912 |
| 11 | Criteria for the classification of early systemic sclerosis | Journal of Rheumatology | 2001 | 910 |
| 12 | Standards for epidemiologic studies and surveillance of epilepsy | Epilepsia | 2011 | 836 |
| 13 | Adrenergic effects on the biology of the adult mammalian cardiocyte. | Circulation | 1992 | 835 |
| 14 | The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind | Journal of Biological Chemistry | 2002 | 803 |
| 15 | Cystic Fibrosis Pulmonary Guidelines | American Journal of Respiratory and Critical Care Medicine | 2007 | 773 |
| 16 | 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 759 |
| 17 | Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial | Lancet Respiratory Medicine,the | 2016 | 754 |
| 18 | Comorbid Depression is Associated With Increased Health Care Use and Expenditures in Individuals With Diabetes | Diabetes Care | 2002 | 685 |
| 19 | The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions | Journal of Biological Chemistry | 1996 | 676 |
| 20 | Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study | Hepatology | 2010 | 629 |
| 21 | Risk factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 years | Gastrointestinal Endoscopy | 2009 | 613 |
| 22 | Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report1 | Allergy: European Journal of Allergy and Clinical Immunology | 2011 | 597 |
| 23 | Comprehensive Analysis of Hypermutation in Human Cancer | Cell | 2017 | 596 |
| 24 | Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2015 | 570 |
| 25 | The Primary Cilium as a Complex Signaling Center | Current Biology | 2009 | 552 |
| 26 | Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation | Journal of Lipid Research | 2005 | 549 |
| 27 | A gp130–Src–YAP module links inflammation to epithelial regeneration | Nature | 2015 | 528 |
| 28 | Pulmonary Strategies of Antioxidant Defense | The American Review of Respiratory Disease | 1989 | 523 |
| 29 | Uncontrolled and Apparent Treatment Resistant Hypertension in the United States, 1988 to 2008 | Circulation | 2011 | 519 |
| 30 | A Simple Methylene Blue-Azure Ii-Basic Fuchsin Stain for Epoxy-Embedded Tissue Sections | Biotechnic & Histochemistry | 1974 | 499 |
| 31 | Transition From Chronic Compensated to Acute Decompensated Heart Failure | Circulation | 2008 | 475 |
| 32 | Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity | Journal of Molecular Medicine | 2010 | 442 |
| 33 | Ceramide synthases at the centre of sphingolipid metabolism and biology | Biochemical Journal | 2012 | 424 |
| 34 | Treatment of lung infection in patients with cystic fibrosis: Current and future strategies | Journal of Cystic Fibrosis | 2012 | 421 |
| 35 | Prevalence and Significance of Alterations in Cardiac Structure and Function in Patients With Heart Failure and a Preserved Ejection Fraction | Circulation | 2011 | 418 |
| 36 | Hexosamines, insulin resistance, and the complications of diabetes: current status | American Journal of Physiology - Endocrinology and Metabolism | 2006 | 415 |
| 37 | Depression and All-Cause and Coronary Heart Disease Mortality Among Adults With and Without Diabetes | Diabetes Care | 2005 | 414 |
| 38 | Preinfarctional (Unstable) Angina—A Prospective Study— Ten Year Follow-Up | Circulation | 1973 | 409 |
| 39 | The Metabolic Significance of Leptin in Humans: Gender-Based Differences in Relationship to Adiposity, Insulin Sensitivity, and Energy Expenditure* | Journal of Clinical Endocrinology and Metabolism | 1997 | 393 |
| 40 | The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria | Allergy: European Journal of Allergy and Clinical Immunology | 2022 | 392 |
| 41 | Thoracic endometriosis syndrome: New observations from an analysis of 110 cases | American Journal of Medicine | 1996 | 389 |
| 42 | Diabetes and depression: Global perspectives | Diabetes Research and Clinical Practice | 2010 | 388 |
| 43 | A comparison of the accuracy of echo features during endoscopic ultrasound (EUS) and EUS-guided fine-needle aspiration for diagnosis of malignant lymph node invasion | Gastrointestinal Endoscopy | 1997 | 384 |
| 44 | Effects of Intensive BP Control in CKD | Journal of the American Society of Nephrology: JASN | 2017 | 364 |
| 45 | Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3 | Journal of Investigative Dermatology | 1999 | 363 |
| 46 | Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases | Circulation | 2006 | 363 |
| 47 | Beyond Desensitization: Physiological Relevance of Arrestin-Dependent Signaling | Pharmacological Reviews | 2010 | 355 |
| 48 | TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression | Cell | 1987 | 352 |
| 49 | Effect of Communication Skills Training for Residents and Nurse Practitioners on Quality of Communication With Patients With Serious Illness | JAMA - Journal of the American Medical Association | 2013 | 346 |
| 50 | ADAM-17: the enzyme that does it all | Critical Reviews in Biochemistry and Molecular Biology | 2010 | 345 |
