| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 2 | Synaptic, transcriptional and chromatin genes disrupted in autism | Nature | 2014 | 2,254 |
| 3 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 4 | Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13 | Science | 1994 | 1,725 |
| 5 | A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer | Nature Genetics | 2007 | 1,370 |
| 6 | Acute respiratory distress syndrome | Nature Reviews Disease Primers | 2019 | 1,364 |
| 7 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 8 | Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome | Blood | 2020 | 1,071 |
| 9 | Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance | Cell Metabolism | 2007 | 1,048 |
| 10 | A structural basis for drug-induced long QT syndrome | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 918 |
| 11 | Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes | Nature Medicine | 2011 | 842 |
| 12 | 2010 i2b2/VA challenge on concepts, assertions, and relations in clinical text | Journal of the American Medical Informatics Association: JAMIA | 2011 | 813 |
| 13 | Phage cocktails and the future of phage therapy | Future Microbiology | 2013 | 692 |
| 14 | Predictive 5-Year Survivorship Model of Cystic Fibrosis | American Journal of Epidemiology | 2001 | 647 |
| 15 | Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis | Journal of Cell Biology | 2001 | 633 |
| 16 | Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. | Journal of Biological Chemistry | 1993 | 607 |
| 17 | Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies | American Journal of Human Genetics | 2005 | 513 |
| 18 | Mechanisms of Vascular Aging | Circulation Research | 2018 | 512 |
| 19 | Pancreatic cancer: from state-of-the-art treatments to promising novel therapies | Nature Reviews Clinical Oncology | 2015 | 489 |
| 20 | A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1) | Nature Genetics | 2009 | 487 |
| 21 | Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines | Journal of Biological Chemistry | 1993 | 486 |
| 22 | Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism | Endocrine Reviews | 2008 | 480 |
| 23 | YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 475 |
| 24 | Glioma Subclassifications and Their Clinical Significance | Neurotherapeutics | 2017 | 471 |
| 25 | IDH1 and IDH2 Mutations in Gliomas | Current Neurology and Neuroscience Reports | 2013 | 469 |
| 26 | Dedifferentiation of Mammalian Myotubes Induced by msx1 | Cell | 2000 | 440 |
| 27 | A polymorphism within a conserved beta1-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 435 |
| 28 | Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 | Nature Genetics | 2009 | 434 |
| 29 | Molecular Biology of Atherosclerosis | Physiological Reviews | 2013 | 418 |
| 30 | Discovery of common and rare genetic risk variants for colorectal cancer | Nature Genetics | 2019 | 377 |
| 31 | Cellular and molecular biology of aging endothelial cells | Journal of Molecular and Cellular Cardiology | 2015 | 367 |
| 32 | The economic burden of incident venous thromboembolism in the United States: A review of estimated attributable healthcare costs | Thrombosis Research | 2016 | 345 |
| 33 | Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study | Atherosclerosis | 2001 | 344 |
| 34 | Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease | Circulation Research | 2018 | 344 |
| 35 | Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenecity of human platelets | Journal of Experimental Medicine | 2006 | 327 |
| 36 | Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency | American Journal of Kidney Diseases | 2020 | 311 |
| 37 | Higher Serum Bilirubin Is Associated With Decreased Risk for Early Familial Coronary Artery Disease | Arteriosclerosis, Thrombosis, and Vascular Biology | 1996 | 304 |
| 38 | A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree | Human Genetics | 2004 | 292 |
| 39 | Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates | Blood | 2009 | 291 |
| 40 | GENETIC HERITABILITY AND COMMON ENVIRONMENTAL COMPONENTS OF RESTING AND STRESSED BLOOD PRESSURES, LIPIDS, AND BODY MASS INDEX IN UTAH PEDIGREES AND TWINS | American Journal of Epidemiology | 1989 | 289 |
| 41 | Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia | Nature Genetics | 2015 | 274 |
| 42 | Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ | Nature | 1998 | 263 |
| 43 | MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate | Cancer Cell | 2020 | 262 |
| 44 | Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death | European Urology | 2017 | 256 |
| 45 | Disruption of diacylglycerol metabolism impairs the induction of T cell anergy | Nature Immunology | 2006 | 254 |
| 46 | The evolving role of platelets in inflammation | Journal of Thrombosis and Haemostasis | 2003 | 253 |
| 47 | Protein synthesis by platelets: historical and new perspectives | Journal of Thrombosis and Haemostasis | 2009 | 251 |
| 48 | Correlation of SARS-CoV-2 RNA in wastewater with COVID-19 disease burden in sewersheds | Science of the Total Environment | 2021 | 243 |
| 49 | Guidance for the evaluation and treatment of hereditary and acquired thrombophilia | Journal of Thrombosis and Thrombolysis | 2016 | 230 |
| 50 | Delay in Recognition of Pulmonary Arterial Hypertension | Chest | 2011 | 228 |
