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Top Articles

#TitleJournalYearCitations
1Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,701
2MicroRNA function in cancer: oncogene or a tumor suppressor?Cancer and Metastasis Reviews2009613
3The Targets of CurcuminCurrent Drug Targets2011613
4Src kinase regulation by phosphorylation and dephosphorylationBiochemical and Biophysical Research Communications2005501
5Src protein–tyrosine kinase structure and regulationBiochemical and Biophysical Research Communications2004471
6Renal cell carcinoma in relation to cigarette smoking: Meta-analysis of 24 studiesInternational Journal of Cancer2005423
7Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and functionAmerican Journal of Physiology - Heart and Circulatory Physiology2004352
8The ErbB/HER receptor protein-tyrosine kinases and cancerBiochemical and Biophysical Research Communications2004349
9An intervention resembling caloric restriction prolongs life span and retards aging in yeastFASEB Journal2000347
10Host Immune Response to Influenza A Virus InfectionFrontiers in Immunology2018321
11Structure and regulation of Kit protein-tyrosine kinase—The stem cell factor receptorBiochemical and Biophysical Research Communications2005299
12Signaling by Kit protein-tyrosine kinase—The stem cell factor receptorBiochemical and Biophysical Research Communications2005258
13Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondPLoS Pathogens2016244
14Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5Free Radical Biology and Medicine2008231
15Role of mTOR Signaling in Tumor Cell Motility, Invasion and MetastasisCurrent Protein and Peptide Science2011229
16Heat Shock Prevents Alpha-synuclein-induced Apoptosis in a Yeast Model of Parkinson's DiseaseJournal of Molecular Biology2005217
17Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell deathFree Radical Biology and Medicine2011214
18Ethanolamine and Phosphatidylethanolamine: Partners in Health and DiseaseOxidative Medicine and Cellular Longevity2017213
19Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cellsLaboratory Investigation2010207
20Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor ComplexCancer Research2009204
21Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathwayInternational Journal of Biochemistry and Cell Biology2009204
22Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell CarcinomasJournal of Biological Chemistry2004196
23Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathwaysOncogene2006184
24Polyarginines Are Potent Furin InhibitorsJournal of Biological Chemistry2000180
25Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent ProteinsMolecular Therapy2006180
26Crystal Structure of the Interferon-induced Ubiquitin-like Protein ISG15Journal of Biological Chemistry2005171
27Actin and Septin Ultrastructures at the Budding Yeast Cell CortexMolecular Biology of the Cell2005170
28Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humansJournal of Molecular and Cellular Cardiology2007165
29Updates of mTOR InhibitorsAnti-Cancer Agents in Medicinal Chemistry2010161
30A Mutation in the ATP2 Gene Abrogates the Age Asymmetry Between Mother and Daughter Cells of the Yeast Saccharomyces cerevisiaeGenetics2002161
31Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR NetworkPLoS ONE2011158
32Translation Initiation Factor eIF4G-1 Binds to eIF3 through the eIF3e SubunitJournal of Biological Chemistry2006154
33Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteinsOncogene2008154
34The Role of Cdc25A in the Regulation of Cell Proliferation and ApoptosisAnti-Cancer Agents in Medicinal Chemistry2012154
35The Skn7 Response Regulator ofSaccharomyces cerevisiaeInteracts with Hsf1 In Vivo and Is Required for the Induction of Heat Shock Genes by Oxidative StressMolecular Biology of the Cell2000152
36A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNAOncogene2015149
37Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2American Journal of Physiology - Renal Physiology2003146
38eIF4E: New Family Members, New Binding Partners, New RolesJournal of Biological Chemistry2009146
39Silenced Chromatin Is Permissive to Activator Binding and PIC RecruitmentCell2001144
40Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents TherapyCells2019142
41Protein prenylation: a pivotal posttranslational processBiochemical and Biophysical Research Communications2003141
42Suppressors of YCK-encoded yeast casein kinase 1deficiency define the four subunits of a novel clathrin AP-like complexEMBO Journal1997137
43The ETO (MTG8) gene familyGene2003137
44ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water MechanismJournal of Biological Chemistry2010135
45Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary CellsJournal of Biological Chemistry2001134
46Domain-Wide Displacement of Histones by Activated Heat Shock Factor Occurs Independently of Swi/Snf and Is Not Correlated with RNA Polymerase II DensityMolecular and Cellular Biology2005133
47Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's diseaseCellular Signalling2014133
48Functional Characterization of Five eIF4E Isoforms inCaenorhabditis elegansJournal of Biological Chemistry2000130
49Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cellsRna2007126
50Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and ActivityJournal of Biological Chemistry2010120