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Department of Pharmacology and Experimental Therapeutics
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top-articles
Department of Pharmacology and Experimental Therapeutics
286
(top 1%)
papers
7.6K
(top 1%)
citations
43
(top 1%)
h
-index
70
(top 1%)
g
-index
301
all documents
7.8K
doc citations
1.5K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Gastric Mucosal Defense and Cytoprotection: Bench to Bedside
Gastroenterology
2008
581
2
Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent
Gut
2008
194
3
Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet β cells modulates insulin secretion in rats
Biochemical and Biophysical Research Communications
2004
178
4
Up-Regulation of Cyclooxygenase-2 by Inhibition of Cyclooxygenase-1: A Key to Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage
Journal of Pharmacology and Experimental Therapeutics
2002
154
5
Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility
World Journal of Gastroenterology
2012
150
6
Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs
Journal of Physiology (Paris)
2001
120
7
Role of Cyclooxygenase (COX)-1 and COX-2 Inhibition in Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage in Rats: Relation to Various Pathogenic Events
Journal of Pharmacology and Experimental Therapeutics
2002
119
8
ROLES OF ENTEROBACTERIA, NITRIC OXIDE AND NEUTROPHIL IN PATHOGENESIS OF INDOMETHACIN-INDUCED SMALL INTESTINAL LESIONS IN RATS
Pharmacological Research
1999
117
9
Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats
Gastroenterology
1997
114
10
Roles of Cyclooxygenase, Prostaglandin E2 and EP Receptors in Mucosal Protection and Ulcer Healing in the Gastrointestinal Tract
Current Pharmaceutical Design
2018
109
11
The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease
Clinical and Experimental Immunology
2010
103
12
Pathogenic Importance of Intestinal Hypermotility in NSAID-Induced Small Intestinal Damage in Rats
Digestion
2002
99
13
16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors
Digestive Diseases and Sciences
2002
90
14
Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage
Clinica Chimica Acta
2010
87
15
Roles of Calcitonin Gene–Related Peptide in Maintenance of Gastric Mucosal Integrity and in Enhancement of Ulcer Healing and Angiogenesis
Gastroenterology
2008
85
16
Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection
Biochemical Pharmacology
2003
84
17
Role of nitric oxide in regulation of gastric acid secretion in rats: effects of NO donors and NO synthase inhibitor
British Journal of Pharmacology
1998
77
18
Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5‐Fluorouracil‐Induced Intestinal Mucositis in Mice
Basic and Clinical Pharmacology and Toxicology
2017
77
19
Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach
Digestive Diseases and Sciences
1998
75
20
Protection against dextran sulfate sodium-induced colitis by microspheres of ellagic acid in rats
Life Sciences
2002
70
21
The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2in rat stomach
Alimentary Pharmacology and Therapeutics
2000
69
22
Protective effect of rebamipide on indomethacin‐induced intestinal damage in rats
Journal of Gastroenterology and Hepatology (Australia)
2001
67
23
5‐
HT
3
receptor antagonists ameliorate 5‐fluorouracil‐induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells
British Journal of Pharmacology
2013
65
24
EP 4 receptor mediation of prostaglandin E 2 -stimulated mucus secretion by rabbit gastric epithelial cells
Biochemical Pharmacology
1999
62
25
Cyclooxygenase-2/prostaglandin E
2
accelerates the healing of gastric ulcers via EP
4
receptors
American Journal of Physiology - Renal Physiology
2007
62
26
Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice
Journal of Pharmacology and Experimental Therapeutics
2001
62
27
Protective Effect of Lafutidine against Indomethacin-Induced Intestinal Ulceration in Rats: Relation to Capsaicin-Sensitive Sensory Neurons
Digestion
2000
61
28
Role of Nitric Oxide in Pathogenesis of Aspirin-Induced Gastric Mucosal Damage in Rats
Digestion
1998
60
29
Prostaglandin EP Receptors Involved in Modulating Gastrointestinal Mucosal Integrity
Journal of Pharmacological Sciences
2010
56
30
Roles of Endogenous Prostaglandins and Cyclooxygenase Isozymes in Healing of Indomethacin-Induced Small Intestinal Lesions in Rats
Journal of Pharmacology and Experimental Therapeutics
2006
55
31
Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin
Journal of Pharmacology and Experimental Therapeutics
1998
55
32
Effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion
Life Sciences
2002
54
33
Exacerbation of Nonsteroidal Anti-Inflammatory Drug-Induced Small Intestinal Lesions by Antisecretory Drugs in Rats: The Role of Intestinal Motility
Journal of Pharmacology and Experimental Therapeutics
2012
54
34
Probiotic
Bifidobacterium bifidum
G9‐1 attenuates 5‐fluorouracil‐induced intestinal mucositis in mice via suppression of dysbiosis‐related secondary inflammatory responses
Clinical and Experimental Pharmacology and Physiology
2017
52
35
Less Damaging Effect of Whisky in Rat Stomachs in Comparison with Pure Ethanol
Digestion
2001
50
36
Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice
American Journal of Physiology - Renal Physiology
2012
49
37
Facilitation by Endogenous Prostaglandins of Capsaicin-Induced Gastric Protection in Rodents through EP2 and IP Receptors
Journal of Pharmacology and Experimental Therapeutics
2003
48
38
Prostaglandin EP Receptors and Their Roles in Mucosal Protection and Ulcer Healing in the Gastrointestinal Tract
Advances in Clinical Chemistry
2010
48
39
Saireito (TJ-114), a Japanese Traditional Herbal Medicine, Reduces 5-Fluorouracil-Induced Intestinal Mucositis in Mice by Inhibiting Cytokine-Mediated Apoptosis in Intestinal Crypt Cells
PLoS ONE
2015
47
40
NSAID-Induced Small Intestinal Damage - Roles of Various Pathogenic Factors
Digestion
2015
46
41
G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells
Pharmacological Research
2017
46
42
Role of endogenous nitric oxide and prostaglandin in duodenal bicarbonate response induced by mucosal acidification in rats
Digestive Diseases and Sciences
2001
45
43
Prostaglandin E Inhibits Indomethacin-Induced Gastric Lesions through EP-1 Receptors
Digestion
2001
45
44
Mechanisms by which endogenous glucocorticoid protects against indomethacin-induced gastric injury in rats
American Journal of Physiology - Renal Physiology
2002
44
45
Aggravation by Selective COX-1 and COX-2 Inhibitors of Dextran Sulfate Sodium (DSS)-Induced Colon Lesions in Rats
Digestive Diseases and Sciences
2007
44
46
The Absence of uPAR Is Associated with the Progression of Dermal Fibrosis
Journal of Investigative Dermatology
2008
44
47
Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5
European Journal of Pharmacology
2013
44
48
Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole
Journal of Clinical Biochemistry and Nutrition
2009
43
49
Role of Serotonin 5-HT<sub>3</sub> Receptors in Intestinal Inflammation
Biological and Pharmaceutical Bulletin
2013
43
50
5‐HT
3
receptors promote colonic inflammation via activation of substance P/neurokinin‐1 receptors in dextran sulphate sodium‐induced murine colitis
British Journal of Pharmacology
2016
42
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