| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Hypoxia — a key regulatory factor in tumour growth | Nature Reviews Cancer | 2002 | 4,590 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 4 | Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress | Cancer Cell | 2015 | 596 |
| 5 | Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization | Nature Medicine | 2011 | 552 |
| 6 | Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival | British Journal of Cancer | 2001 | 438 |
| 7 | Consensus guidelines for the use and interpretation of angiogenesis assays | Angiogenesis | 2018 | 429 |
| 8 | Tumor-associated macrophages in breast cancer | Journal of Mammary Gland Biology and Neoplasia | 2002 | 330 |
| 9 | Up-regulation of Delta-like 4 Ligand in Human Tumor Vasculature and the Role of Basal Expression in Endothelial Cell Function | Cancer Research | 2005 | 323 |
| 10 | Regulation of autophagy by ATF4 in response to severe hypoxia | Oncogene | 2010 | 320 |
| 11 | Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells | Cell Metabolism | 2012 | 320 |
| 12 | MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU | PLoS ONE | 2010 | 276 |
| 13 | Imaging tumour hypoxia with positron emission tomography | British Journal of Cancer | 2015 | 272 |
| 14 | The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib | Cancer Research | 2009 | 263 |
| 15 | Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease | Cancer Research | 2002 | 250 |
| 16 | The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis | British Journal of Cancer | 2011 | 244 |
| 17 | Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target | Cell Cycle | 2004 | 234 |
| 18 | Hypoxia-Inducible Factor-1α Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer | Clinical Cancer Research | 2006 | 223 |
| 19 | DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo | Cancer Research | 2011 | 212 |
| 20 | Association of hypoxia-inducible factors 1? and 2? with activated angiogenic pathways and prognosis in patients with endometrial carcinoma | Cancer | 2002 | 207 |
| 21 | Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells | Microvascular Research | 2008 | 202 |
| 22 | Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments | Cancer & Metabolism | 2016 | 186 |
| 23 | Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy | Journal of Molecular Medicine | 2016 | 172 |
| 24 | The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor α and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth | Cancer Research | 2010 | 167 |
| 25 | Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis | Arthritis Research | 2003 | 164 |
| 26 | hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan | British Journal of Cancer | 2003 | 163 |
| 27 | Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia | British Journal of Cancer | 2010 | 141 |
| 28 | A novel method for autophagy detection in primary cells | Autophagy | 2012 | 141 |
| 29 | miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis | British Journal of Cancer | 2013 | 134 |
| 30 | Immunomodulation of FOXP3+ Regulatory T Cells by the Aromatase Inhibitor Letrozole in Breast Cancer Patients | Clinical Cancer Research | 2009 | 133 |
| 31 | Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival | Biochemical Journal | 2013 | 128 |
| 32 | Phosphorylated ERα, HIF-1α, and MAPK Signaling As Predictors of Primary Endocrine Treatment Response and Resistance in Patients With Breast Cancer | Journal of Clinical Oncology | 2009 | 116 |
| 33 | HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer | PLoS Biology | 2010 | 116 |
| 34 | Non-angiogenic tumours and their influence on cancer biology | Nature Reviews Cancer | 2018 | 113 |
| 35 | Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 110 |
| 36 | miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense | Cancer Research | 2018 | 105 |
| 37 | Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2 | Journal of Pathology | 2002 | 103 |
| 38 | Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer | Cancer Gene Therapy | 2005 | 103 |
| 39 | LC3A-Positive Light Microscopy Detected Patterns of Autophagy and Prognosis in Operable Breast Carcinomas | American Journal of Pathology | 2010 | 101 |
| 40 | The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer | Gynecologic Oncology | 2008 | 98 |
| 41 | Role of Hypoxia‐Inducible Factors in Epigenetic Regulation via Histone Demethylases | Annals of the New York Academy of Sciences | 2009 | 98 |
| 42 | RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer | Oncogene | 2007 | 92 |
| 43 | Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer | Cell Metabolism | 2018 | 92 |
| 44 | EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination | Oncogene | 2015 | 91 |
| 45 | Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene | British Journal of Cancer | 2004 | 89 |
| 46 | Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies | Angiogenesis | 2008 | 89 |
| 47 | Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis | Gynecologic Oncology | 2006 | 88 |
| 48 | Cytoplasmic p21 WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis | Breast Cancer Research | 2003 | 85 |
| 49 | Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? | Trends in Molecular Medicine | 2007 | 84 |
| 50 | Lactate Dehydrogenase 5 Expression in Squamous Cell Head and Neck Cancer Relates to Prognosis following Radical or Postoperative Radiotherapy | Oncology | 2009 | 82 |
