| # | Title | Journal | Year | Citations |
|---|
| 1 | The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Nature | 1999 | 4,528 |
| 2 | ABC Transporters: From Microorganisms to Man | Annual Review of Cell Biology | 1992 | 3,690 |
| 3 | Life with 6000 Genes | Science | 1996 | 3,548 |
| 4 | Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis | Nature | 1998 | 2,565 |
| 5 | HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C | Nature | 1998 | 1,983 |
| 6 | Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis | Nature Medicine | 2001 | 1,555 |
| 7 | Common West African HLA antigens are associated with protection from severe malaria | Nature | 1991 | 1,494 |
| 8 | A serine/threonine kinase gene defective in Peutz–Jeghers syndrome | Nature | 1998 | 1,451 |
| 9 | Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections | Nature Medicine | 2002 | 1,432 |
| 10 | Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing | Science | 2000 | 1,258 |
| 11 | Antigen Recognition by Class I-Restricted T Lymphocytes | Annual Review of Immunology | 1989 | 1,218 |
| 12 | Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 1,210 |
| 13 | Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport | Nature | 1990 | 1,174 |
| 14 | Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria | Nature | 1994 | 1,169 |
| 15 | World distribution of factor V Leiden | Lancet, The | 1995 | 1,153 |
| 16 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics | Nature Medicine | 2001 | 1,113 |
| 17 | Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies | Nature Medicine | 2001 | 1,083 |
| 18 | Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition | Nature | 1991 | 1,060 |
| 19 | Increased expression of mutant forms of p53 oncogene in primary lung cancer | Lancet, The | 1990 | 1,048 |
| 20 | Association of class I major histocompatibility heavy and light chains induced by viral peptides | Nature | 1989 | 1,015 |
| 21 | Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 955 |
| 22 | Hypoxia-inducible expression of tumor-associated carbonic anhydrases | Cancer Research | 2000 | 946 |
| 23 | Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor | Journal of Biological Chemistry | 2004 | 918 |
| 24 | Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1 | Developmental Cell | 2002 | 903 |
| 25 | Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome | Nature Genetics | 1995 | 892 |
| 26 | The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains | Nature Genetics | 1995 | 846 |
| 27 | Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo | Journal of Experimental Medicine | 1998 | 830 |
| 28 | HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function | Journal of Experimental Medicine | 2000 | 820 |
| 29 | An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita | Nature | 1994 | 796 |
| 30 | Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer | Lancet, The | 1992 | 790 |
| 31 | An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype | EMBO Journal | 2002 | 783 |
| 32 | HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women | Nature Medicine | 1995 | 771 |
| 33 | The Role of Virus-Specific Cd8+ Cells in Liver Damage and Viral Control during Persistent Hepatitis B Virus Infection | Journal of Experimental Medicine | 2000 | 761 |
| 34 | Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters | Nature | 1990 | 731 |
| 35 | Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism | Nature | 1994 | 722 |
| 36 | Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene | Nature Genetics | 1998 | 720 |
| 37 | Adaptive evolution of highly mutable loci in pathogenic bacteria | Current Biology | 1994 | 719 |
| 38 | Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus | Nature Genetics | 1995 | 712 |
| 39 | Is the multidrug transporter a flippase? | Trends in Biochemical Sciences | 1992 | 700 |
| 40 | Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis | Cancer Research | 1997 | 656 |
| 41 | Molecular analysis of the association of HLA-B53 and resistance to severe malaria | Nature | 1992 | 638 |
| 42 | Rapid switching to multiple antigenic and adhesive phenotypes in malaria | Nature | 1992 | 593 |
| 43 | Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein | Nature | 1992 | 580 |
| 44 | TRAP Is Necessary for Gliding Motility and Infectivity of Plasmodium Sporozoites | Cell | 1997 | 580 |
| 45 | Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q1 1.2–13.3 | Nature | 1990 | 567 |
| 46 | Very mild muscular dystrophy associated with the deletion of 46% of dystrophin | Nature | 1990 | 565 |
| 47 | Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α | Blood | 1998 | 557 |
| 48 | Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40 | Science | 2000 | 554 |
| 49 | Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells | Nature | 1999 | 553 |
| 50 | Cellular immune responses to HIV | Nature | 2001 | 550 |
