| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Decreased extra-renal urate excretion is a common cause of hyperuricemia | Nature Communications | 2012 | 489 |
| 3 | The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation | Diabetologia | 2010 | 391 |
| 4 | Clinical and Molecular Analysis of Patients with Renal Hypouricemia in Japan-Influence of URAT1 Gene on Urinary Urate Excretion | Journal of the American Society of Nephrology: JASN | 2004 | 340 |
| 5 | Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population | Science Translational Medicine | 2009 | 334 |
| 6 | Neuroprotective Effects of Edaravone: a Novel Free Radical Scavenger in Cerebrovascular Injury | CNS Neuroscience & Therapeutics | 2006 | 324 |
| 7 | Deletion of the NESP55 differentially methylated region causes loss of maternal GNAS imprints and pseudohypoparathyroidism type Ib | Nature Genetics | 2005 | 321 |
| 8 | Diabetic Cardiovascular Disease Induced by Oxidative Stress | International Journal of Molecular Sciences | 2015 | 314 |
| 9 | Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis | Nature Communications | 2019 | 303 |
| 10 | Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy. | Journal of Clinical Investigation | 1995 | 289 |
| 11 | Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance | Lancet, The | 2009 | 272 |
| 12 | Insufficient autophagy in idiopathic pulmonary fibrosis | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2013 | 259 |
| 13 | Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2011 | 257 |
| 14 | Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study | Blood | 2011 | 218 |
| 15 | The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer | Molecular Therapy | 2015 | 218 |
| 16 | 2008 Japanese Society for Dialysis Therapy: Guidelines for Renal Anemia in Chronic Kidney Disease | Therapeutic Apheresis and Dialysis | 2010 | 211 |
| 17 | PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis | Autophagy | 2015 | 206 |
| 18 | Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease | OncoImmunology | 2012 | 199 |
| 19 | Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients | Leukemia | 2014 | 199 |
| 20 | The Potential of Bone Marrow-Derived Cells to Differentiate to Glomerular Mesangial Cells | Journal of the American Society of Nephrology: JASN | 2001 | 192 |
| 21 | Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis | Journal of Extracellular Vesicles | 2015 | 187 |
| 22 | Piccolo, a Ca2+ Sensor in Pancreatic β-Cells | Journal of Biological Chemistry | 2002 | 179 |
| 23 | Metformin attenuates lung fibrosis development via NOX4 suppression | Respiratory Research | 2016 | 178 |
| 24 | Chemical Xenobiotics and Mitochondrial Autoantigens in Primary Biliary Cirrhosis: Identification of Antibodies against a Common Environmental, Cosmetic, and Food Additive, 2-Octynoic Acid | Journal of Immunology | 2005 | 176 |
| 25 | Induction therapy by frequent administration of doxorubicin with four other drugs, followed by intensive consolidation and maintenance therapy for adult acute lymphoblastic leukemia: the JALSG-ALL93 study | Leukemia | 2002 | 171 |
| 26 | Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers | Hepatology | 2013 | 171 |
| 27 | Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study | Cardiovascular Diabetology | 2014 | 168 |
| 28 | Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2013 | 167 |
| 29 | Angiotensin I converting enzyme gene polymorphism in non-insulin dependent diabetes mellitus | Kidney International | 1996 | 164 |
| 30 | Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence | Journal of Immunology | 2014 | 156 |
| 31 | A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study | Blood | 2011 | 155 |
| 32 | Uricosuric Action of Losartan via the Inhibition of Urate Transporter 1 (URAT 1) in Hypertensive Patients | American Journal of Hypertension | 2008 | 149 |
| 33 | A multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy in patients with immunoglobulin A nephropathy | Nephrology Dialysis Transplantation | 2014 | 149 |
| 34 | Extracellular vesicles in lung microenvironment and pathogenesis | Trends in Molecular Medicine | 2015 | 149 |
| 35 | Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes | Annals of the Rheumatic Diseases | 2016 | 144 |
| 36 | Function and Localization of Urate Transporter 1 in Mouse Kidney | Journal of the American Society of Nephrology: JASN | 2004 | 143 |
| 37 | Recommendations on the Management of Encapsulating Peritoneal Sclerosis in Japan, 2005: Diagnosis, Predictive Markers, Treatment, and Preventive Measures | Peritoneal Dialysis International | 2005 | 141 |
| 38 | The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats | European Journal of Pharmacology | 2007 | 138 |
| 39 | Mortality Trends in Type 1 Diabetes: The Allegheny County (Pennsylvania) Registry 1965-1999 | Diabetes Care | 2001 | 137 |
| 40 | Serum Phosphate and Calcium Should Be Primarily and Consistently Controlled in Prevalent Hemodialysis Patients | Therapeutic Apheresis and Dialysis | 2013 | 133 |
| 41 | Mutation of Human Molybdenum Cofactor Sulfurase Gene Is Responsible for Classical Xanthinuria Type II | Biochemical and Biophysical Research Communications | 2001 | 131 |
| 42 | Clinical Application of Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapeutics for Inflammatory Lung Diseases | Journal of Clinical Medicine | 2018 | 128 |
| 43 | Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update | Nutrition, Metabolism and Cardiovascular Diseases | 2006 | 127 |
| 44 | Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease | Pathology International | 2002 | 125 |
| 45 | ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload | Scientific Reports | 2014 | 125 |
| 46 | SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy | International Journal of Molecular Sciences | 2017 | 124 |
| 47 | The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis: A prospective, multicenter study | Hepatology Research | 2008 | 123 |
| 48 | Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout | Clinical and Experimental Nephrology | 2014 | 123 |
| 49 | Apaf-1 Is a Mediator of E2F-1-induced Apoptosis | Journal of Biological Chemistry | 2002 | 119 |
| 50 | Urate transport via human PAH transporter hOAT1 and its gene structure | Kidney International | 2003 | 118 |
